Immunogen: Peroxynitrite-treated keyhole limpet hemocyanin • Host: Mouse • Species Reactivity: (+) Species independent • Applications: ELISA

Nitrotyrosine Monoclonal Antibody – 200 µg

Brand:
Cayman
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Nitrotyrosine is a post-translational modification that is formed by the nitration of tyrosine.{60009} Under conditions of oxidative stress, tyrosine is oxidized by reactive oxygen species (ROS) or, in the presence of hydrogen peroxide and nitrite, by myeloperoxidase (MPO) to yield a tyrosine radical that reacts with reactive nitrogen species (RNS), such as nitric oxide or peroxynitrite, to form nitrotyrosine. It exists in a free or protein-bound form and is commonly used as a marker of nitrosative or oxidative stress.{31710} Nitrotyrosine residues have been found in a variety of proteins, including LDL, surfactant protein A, angiotensin II, and human and bovine serum albumin.{60010} Free nitrotyrosine production induced by peroxynitrite is inhibited by the polyphenols epicatechin gallate, gallic acid, catechin, or epicatechin in cell-free assays, as well as in aortic rings isolated from normotensive and spontaneously hypertensive rats administered the antioxidant N-acetyl-cysteine (NAC; Item No. 20261).{60011,60012} Nitrotyrosine levels are increased in the affected tissues of numerous pathological conditions, including atherosclerosis, cancer, ulcerative colitis, Alzheimer’s disease, and Parkinson’s disease.{60010} Autoantibodies that recognize nitrotyrosinated proteins are increased in the synovium of patients with rheumatoid arthritis and are positively correlated with joint and tendon inflammation.{60009} Cayman’s Nitrotyrosine Monoclonal Antibody can be used for ELISA and Western blot (WB) applications.  

 

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SKU: 189542 - 200 µg Category:

Description

Immunogen: Peroxynitrite-treated keyhole limpet hemocyanin • Host: Mouse • Species Reactivity: (+) Species independent • Applications: ELISA, WB

Synonyms: 3-Nitrotyrosine|NT

Immunogen: Peroxynitrite-treated KLH

Formulation: 50 µg or 200 µg of protein G-purified antibody

Isotype: IgG2b

Applications: ELISA and WB

Origin: Animal/Mouse

Stability: 365 days

Application|ELISA||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cancer||Research Area|Cardiovascular System|Blood|Acute Phase Reactants||Research Area|Cardiovascular System|Blood|Serum Proteins||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Gastric Disease|Ulcerative Colitis||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease||Research Area|Oxidative Stress & Reactive Species|Protein Oxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Nitrogen||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Myeloperoxidase

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