Immunogen: Peptide from the C-terminal region of human CD56 • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) Human NCAM-180

NCAM1/CD56 (C-Term) Rabbit Monoclonal Antibody – 100 µl

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Cayman
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CD56, also known as neural cell adhesion molecule 1 (NCAM1), is a cell surface glycoprotein and member of the immunoglobulin superfamily that is involved in cellular adhesion and neural development.{60124,60125,60126} Alternative splicing of the NCAM1 pre-mRNA produces several isoforms, including two transmembrane isoforms of 180 and 140 kDa, NCAM-180 and NCAM-140, respectively, that differ in size of the cytoplasmic domain, and a 120 kDa isoform, NCAM-120, that lacks the cytoplasmic domain and is linked to the plasma membrane by a glycosylphosphatidylinositol (GPI) anchor.{60124} CD56 is composed of an extracellular N-terminal domain containing five immunoglobulin-like (Ig-like) domains and two fibronectin type III domains that mediate homophilic and heterophilic interactions, a transmembrane domain, and an intracellular C-terminal signaling domain.{60125,60127} It is used as a marker for neural and natural killer (NK) cells, but is also expressed by other immune cells, including monocytes, T cells, and dendritic cells (DCs), as well as tumor cells, in an isoform-dependent manner.{60124,60125,60127} CD56 is increased on NK cells by stimulation with IL-15 or IL-2 and correlates with upregulation of the NK cell activating receptors NKG2D, NKp30, and NKp46 and NK cell-mediated cytotoxicity.{60124,60127} Homophilic CD56 interactions induce neurite outgrowth of cerebellar neurons and promote NK cell-mediated tumor cell lysis in vitro.{60124,60125,60126,60127} The frequency of peripheral blood CD56bright NK cells is increased in patients with melanoma and associated with reduced overall survival.{60128} Cayman’s NCAM1/CD56 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes NCAM-180 and NCAM-140 from human samples.  

 

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SKU: 32257 - 100 µl Category:

Description

Immunogen: Peptide from the C-terminal region of human CD56 • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) Human NCAM-180, NCAM-140; (-) Human NCAM-120 • Applications: IHC, WB

Synonyms: Cluster of Differentiation 56|NCAM1|Neural Cell Adhesion Molecule 1

Immunogen: Peptide from the C-terminal region of human CD56

Formulation: 100 µl of protein A-affinity purified monoclonal antibody

Isotype: IgG

Applications: IHC, WB

Origin:

Stability: 365 days

Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cancer|Immunology||Research Area|Cell Biology|ECM & Adhesion Molecules||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience

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