Immunogen: Recombinant human MFF • Host: Rabbit • Species Reactivity: (+) Human

Mitochondrial Fission Factor Polyclonal Antibody – 100 µl

Brand:
Cayman
Storage:

Mitochondrial fission factor (MFF) is a tail-anchored membrane protein with roles in mitochondrial and peroxisomal fission.{55234,59142} It is localized to the outer membrane of mitochondria, as well as the membrane-restricted regions of elongated peroxisomes. It is composed of a cytoplasmic N-terminus that functions as a receptor for the GTPases dynamin-related protein 1 (DRP1) and dynamin-like protein 1 (DLP1), a central coiled-coil domain, and a C-terminal transmembrane domain.{59144} siRNA knockdown of MFF inhibits DRP1 recruitment and mitochondrial fission induced by loss of mitochondrial membrane potential and delays cytochrome c release from mitochondria and apoptotic progression in vitro.{55234,59144} MicroRNA knockdown of MFF inhibits norepinephrine-induced hypertrophy and mitochondrial fission in isolated neonatal rat ventricular cells.{59144} MFF is overexpressed in various cancer cells and knockdown of MFF reduces tumor volume in a PC3 mouse xenograft model.{59143} Cayman’s Mitochondrial Fission Factor Polyclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes MFF at approximately 38 kDa from human, bovine, and mouse samples.  

 

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SKU: 29284 - 100 µl Category:

Description

Immunogen: Recombinant human MFF • Host: Rabbit • Species Reactivity: (+) Human, Bovine, Mouse • Applications: IHC, WB • MW = ~38 kDa

Synonyms: Chromosome Open Reading Frame 33|MFF

Immunogen: Recombinant human MFF

Formulation: 100 µl of polyclonal antibody neat serum

Isotype:

Applications: IHC, WB

Origin:

Stability: 365 days

Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cancer||Research Area|Cardiovascular System|Heart|Myocardial Hypertrophy||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking||Research Area|Cell Biology|Mitochondrial Biology

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