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MEK1 (Phospho-Thr386) Polyclonal Antibody – 1 ea

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Cayman
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MAP kinase kinase 1 (MEK1) is an integral component of the MAP kinase cascade that regulates cell growth and differentiation {14328,14329}. This pathway also plays a key role in synaptic plasticity in the brain {14327}. Activated MEK1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase {14331,14332,14543}. Conversely, there also appears to be a feedback phosphorylation of MEK1 by MAP kinase. The sites on MEK1 that are phosphorylated by MAP kinase are Thr292 and Thr386 {14330}.  

 

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SKU: 10009517 - 1 ea Category:

Description

Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Thr386 of human MEK 1; expected to react with bovine, canine, chicken, mouse, non-human primates, and Xenopus MEK1 • Host: rabbit • Cross Reactivity: (+) rat MEK1 • Application(s): WB • MEK1 is an integral component of the MAPK cascade that regulates cell growth and differentiation. MEK1 is phosphorylated by MAPK on Thr292 and Thr386.

Synonyms: MAP Kinase Kinase 1|MAPKK1|Mitogen-activated Protein Kinase Kinase 1

Immunogen: phosphopeptide corresponding to amino acid residues surrounding the Phospho-Thr386 of human MEK1

Formulation: Affinity-purified IgG

Isotype:

Applications: WB

Origin: Animal/Rabbit

Stability: 365 days

Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling

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