LSD1 Polyclonal Antibody (aa 450-500) – 1 ea

Brand:
Cayman
Storage:

LSD1, the first known lysine-specific histone demethylase, is an 886 amino acid nuclear protein belonging to flavin monoamine oxidase family. It contains a SWIRM domain, a FAD-binding motif and an amine oxidase domaine. This protein is ubiquitously expressed and is a component of several histone deacetylase complexes. LSD1 acts as a component of the CoREST and other transcriptional co-repressor complexes and also plays an important role in silencing neuronal-specific genes in non-neuronal cells. It is also known to demethylate Lys4 of histone H3, a specific tag for epigenetic transcriptional activation. Reports suggest that it plays an important role in stimulating androgen-receptor-dependent transcription converting oxygen to hydrogen peroxide (might use alternative electron acceptors). Along with nuclear FHL2 it serves as a novel biomarker predictive for prostate cancer.  

 

Available on backorder

SKU: 13486 - 1 ea Category:

Description

Antigen: synthetic peptide from human LSD1 amino acids 450-500 • Host: rabbit • Cross Reactivity: (+) chimpanzee, bovine, canine, equine, human, mouse, orangutan, and porcine LSD1 • Application(s): WB • LSD1 is a lysine-specific histone demethylase that acts as a component of CoREST and other transcriptional co-repressor complexes. It plays an important role in silencing neuronal-specific genes in non-neuronal cells and is also known to demethylate Lys4 of histone H3, a specific tag for epigenetic transcriptional activation.


Synonyms: KDM1

Immunogen: synthetic peptide from human LSD1 amino acids 450-500

Formulation: 100 µg of protein A-purified IgG

Isotype:

Applications: WB

Origin: Animal/Rabbit

Stability: 365 days


Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Demethylation