LTB4 is synthesized from arachidonic acid by the combined action of 5-LO and LTA4 hydrolase. LTB4 has long been recognized as a potent mediator of inflammation. It stimulates a number of leukocyte functions

Leukotriene B4 ELISA Kit – 480 solid wells

Brand:
Cayman
Storage:
-20

Leukotriene B4 (LTB4) is synthesized from arachidonic acid by the combined action of 5-lipoxygenase and LTA4 hydrolase.{1719} LTB4 has long been recognized as a potent mediator of inflammation. It stimulates a number of leukocyte functions, including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis.{329,1803} In subnanomolar ranges (3.9 x 10−10 M), LTB4 causes chemotaxis and chemokinesis in human PMNLs.{329} At higher concentrations, (1.0 x 10−7 M), LTB4 leads to neutrophil aggregation and degranulation as well as superoxide anion production.{329,83} Plasma levels of LTB4 increase from 100 ng/ml following leukocyte stimulation.{1534,1454,1346} LTB4 is metabolized in leukocytes and hepatocytes to less active 20-hydroxy and 20-carboxy LTB4 by NADPH-dependent cytochrome P450 enzymes followed by β-oxidation at the ω-end to ω-carboxy dinor LTB4 and ω-carboxy tetranor LTB3.{1803,589,1032,377} LTB4 is not excreted in the urine.{1465}  

 

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Description

LTB4 is synthesized from arachidonic acid by the combined action of 5-LO and LTA4 hydrolase. LTB4 has long been recognized as a potent mediator of inflammation. It stimulates a number of leukocyte functions, including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. In subnanomolar ranges ,(3.9 x 10-10 M), LTB4 causes chemotaxis and chemokinesis in human PMNLs. At higher concentrations, (1.0 x 10-7 M), LTB4 leads to neutrophil aggregation and degranulation as well as superoxide anion production. Plasma levels of LTB4 increase from 100 ng/ml following leukocyte stimulation. LTB4 is metabolized in leukocytes and hepatocytes to less active 20-hydroxy and 20-carboxy LTB4 and is not excreted in the urine.

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Synonyms:  LTB4 EIA Kit

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Origin: Animal/Mouse|Animal/Bovine|Animal/Eel|Animal/Rabbit

Application|ELISA||Product Type|Assay Kits|ELISA||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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