Immunogen: Synthetic peptide from the C-terminal region of mouse LDL Receptor • Host: Rabbit • Species Reactivity: (+) Human

LDL Receptor Polyclonal Antibody – 1 ea

Brand:
Cayman
Storage:

Cholesterol is an essential element of cell membranes and is carried around the body packaged in lipoproteins, primarily low-density lipoproteins (LDLs). The LDL receptors (LDLRs) are cell surface glycoproteins that scavenge LDL from the blood and regulate plasma LDL cholesterol. LDLRs contain five primary domains: the ligand binding domain, the homology with the EGF precursor domain, the O-linked sugars domain, the membrane-spanning region, and a cytoplasmic tail.{13847} In humans, more than 60% of the LDL R3 are found in the liver.{13846} LDLR expression is under hormonal control both in vivo and in vitro. Mutations in the LDLR gene cause disorders such as familial hypercholesterolemia and atherosclerosis.{13847} Murine LDLR is 864 amino acids in length with an estimated molecular weight of 95 kDa. The protein is highly glycosylated through N- and O-linkages and thus migrates at 100 to 160 kDa bands on SDS-PAGE.{13847} Cayman’s LDL receptor polyclonal antibody detects both glycosylated and unglycosylated proteins in tissue/cell samples such as liver, HepG2, and RAW 264.7 cells.  

 

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SKU: 10007665 - 1 ea Category:

Description

Immunogen: Synthetic peptide from the C-terminal region of mouse LDL Receptor • Host: Rabbit • Species Reactivity: (+) Human, mouse, and rat • Application(s): ICC, IHC, and WB

Synonyms: LDLR|Low Density Lipoprotein Receptor

Immunogen: Synthetic peptide from the C-terminal region of mouse LDL Receptor

Formulation: 500 µl of peptide affinity-purified antibody

Isotype:

Applications: ICC, IHC, and WB

Origin: Animal/Rabbit

Stability: 365 days

Application|Immunocytochemistry||Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Endocrinology & Metabolism|Inborn Errors of Metabolism||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias

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