Immunogen: IRF3 (human recombinant) • Host: Mouse • Species reactivity: (+) Human IRF3 • Applications: ELISA

IRF3 Monoclonal Antibody (Clone 1E10) – 100 µg

Brand:
Cayman
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Interferon regulatory factor 3 (IRF3) is a member of the IRF family that plays a crucial role in activation of innate immunity and inflammation in response to viral infection, functioning as a molecular switch for antiviral activity.{39335,39336,39338,39337,39339} Double-stranded RNA generated during a viral infection leads to IRF3 activation through serine/threonine phosphorylation by TBK1 (Item No. 22817) or IKKε (IKBKE) kinases, which induces a conformational change leading to its dimerization, nuclear localization, and association with CREB binding protein (CREBBP)/p300.{39335,39336,39338,39334} The complex formed by this association, known as DRAF1, activates transcription of interferon α (IFN-α) and IFN-β as well as other IFN-induced genes, which play a critical role in the type 1 IFN-dependent immune response.{39335,39334,39339} Cayman’s IRF3 Monoclonal Antibody can be used for Western blot and ELISA applications. The antibody recognizes IRF3 at ~47 kDa from human samples.  

 

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SKU: 25921 - 100 µg Category:

Description

Immunogen: IRF3 (human recombinant) • Host: Mouse • Species reactivity: (+) Human IRF3 • Applications: ELISA, WB,

Synonyms: Interferon Regulatory Factor 3

Immunogen: IRF3 (human recombinant)

Formulation: 100 µg of protein G-purified antibody

Isotype: IgG2a

Applications: ELISA and WB

Origin:

Stability: 365 days

Application|ELISA||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease|Viral Diseases

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