Antigen: synthetic peptide corresponding to a mixture of mouse IRAK-4 amino acids 38-54 and 120-136 • Host: rabbit • Cross Reactivity: (+) human and mouse IRAK-4 • Application(s): IP and WB • IRAK-4 may act as an upstream activator of IRAK-1 and is important for LPS activation of TLRs. Mice lacking IRAK4 are resistant to lethal doses of LPS and are also severely impaired in their responses to viral and bacterial challenges.

IRAK-4 Polyclonal Antibody – 1 ea

Brand:
Cayman
Storage:

The toll-like receptor (TLR) family in mammals comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules.{17503} Interleukin-1 receptor-associated kinases (IRAKs) are important mediators in the signal transduction of Toll/IL-1 receptor (TIR) family members.{18761} The cytoplasmic domains of TIR proteins interact with the adapter protein, MyD88. MyD88 then recruits IRAKs (IRAK-1-4), which in turn interact with other adapter molecules, such as TRAF6 to activate NF-κB and MAPK pathways. A member of this family, IRAK-4 has been identified.{18762} IRAK-4 may act as an upstream activator of IRAK-1. IRAK-4 is important for LPS activation of TLRs. Mice lacking IRAK4 are resistant to lethal doses of LPS and are also severely impaired in their responses to viral and bacterial challenges.{18763,18764}  

 

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SKU: 13845 - 1 ea Category:

Description

Antigen: synthetic peptide corresponding to a mixture of mouse IRAK-4 amino acids 38-54 and 120-136 • Host: rabbit • Cross Reactivity: (+) human and mouse IRAK-4 • Application(s): IP and WB • IRAK-4 may act as an upstream activator of IRAK-1 and is important for LPS activation of TLRs. Mice lacking IRAK4 are resistant to lethal doses of LPS and are also severely impaired in their responses to viral and bacterial challenges.

Synonyms: Interleukin-1 Receptor-Associated Kinase-Like 4

Immunogen: synthetic peptide corresponding to a mixture of mouse IRAK-4 amino acids 38-54 and 120-136

Formulation: 100 µg protein G-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide

Isotype:

Applications: IP and WB

Origin:

Stability: 180 days

Application|Immunoprecipitation||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Parasitic Diseases

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