Antigen: synthetic peptide corresponding to human IRAK-1 amino acids 700-712 • Host: rabbit • Cross Reactivity: (+) human and mouse IRAK-1; (−) IRAK-2 • Application(s): IP and WB • IRAK-1 is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. It mediates a signaling cascade leading to NF-κB activation by members of the IL-1 family including IL-1 and IL-18.

IRAK-1 Polyclonal Antibody – 1 ea

Brand:
Cayman
Storage:

Nuclear factor-κB (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNF-α, and LPS. A serine/threonine protein kinase associated with interleukin-1 receptor-associated kinase 1 (IRAK-1) and its homologue murine pelle-like protein kinase (mPLK) has been identified.{10659,18740} IRAK-1 is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response.{18739} IRAK-1 mediates a signaling cascade leading to NF-κB activation by members of the IL-1 family including IL-1 and IL-18 (also known as IGIF).{2150,18740}  

 

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SKU: 13843 - 1 ea Category:

Description

Antigen: synthetic peptide corresponding to human IRAK-1 amino acids 700-712 • Host: rabbit • Cross Reactivity: (+) human and mouse IRAK-1; (−) IRAK-2 • Application(s): IP and WB • IRAK-1 is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. It mediates a signaling cascade leading to NF-κB activation by members of the IL-1 family including IL-1 and IL-18.

Synonyms: Interleukin-1 Receptor-Associated Kinase 1

Immunogen: synthetic peptide corresponding to human IRAK-1 amino acids 700-712

Formulation: 100 µg of protein G-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide

Isotype:

Applications: IP and WB

Origin:

Stability: 180 days

Application|Immunoprecipitation||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation

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