Immunogen: Human IgG3 • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (-) Human IgG1

IgG3 (human) Rabbit Monoclonal Antibody – 100 µg

Brand:
Cayman
Storage:

Immunoglobulin G (IgG) is a member of the immunoglobulin superfamily of glycoproteins that plays a central role in the adaptive immune response.{28520} It is produced by B cells and later secreted by plasma cells and is the most abundant circulating antibody in human and mouse serum.{28520,55170,55174} IgG consists of two heavy chains of approximately 50 kDa each and two light chains of approximately 25 kDa each.{28520} The heavy chains are linked together by disulfide bonds to form an Fc region and also combine with the light chains to form the Fab region, which mediate receptor and antigen binding, respectively.{55171} IgG is produced following IgM class-switching in response to infection and is involved in numerous humoral host defense responses, including antibody-dependent cell-mediated cytotoxicity (ADCC), toxin neutralization, and pathogen opsonization.{55170} IgG exists as four isotypes in humans, IgG1, IgG2, IgG3, and IgG4, each of which has a distinct effector function. IgG3 production is driven by bacterial- or viral-associated antigens, including HIV-1 and Staphylococcus antigens, and occurs early in the immune response following IgM class-switching.{55170,52653} IgG3 binds to and neutralizes pathogens, as well as activates complement and opsonizes bacteria, leading to complement-dependent cytotoxicity (CDC) and ADCC, respectively. Serum IgG3 levels are increased in patients with primary biliary cirrhosis, Sjögren’s syndrome, systemic sclerosis, or systemic lupus erythematosus (SLE).{52654} Cayman’s IgG3 (human) Rabbit Monoclonal Antibody can be used for ELISA, immunocytochemistry (ICC), and immunohistochemistry (IHC) applications.  

 

Available on backorder

Add to quotes
SKU: 32122 - 100 µg Category:

Description

Immunogen: Human IgG3 • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (-) Human IgG1, IgG2, IgG4, IgM, IgA, IgD, IgE; (-) Cynomolgus monkey, goat, mouse, rat, or rhesus monkey IgG • Applications: ELISA, ICC, IHC

Synonyms: Immunoglobulin G3

Immunogen: Human IgG3

Formulation: 100 µg of protein A-affinity purified monoclonal antibody

Isotype: IgG

Applications: ELISA, ICC, IHC

Origin:

Stability: 365 days

Application|ELISA||Application|Immunocytochemistry||Application|Immunohistochemistry||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cardiovascular System|Blood|Serum Proteins||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Autoimmunity|Lupus||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

Related products