Immunogen: Human recombinant protein • Host: Rabbit • Species Reactivity: (+) Human and rat • Applications: ELISA

Hsp70 (HspA1A) Polyclonal Antibody – 200 µg

Brand:
Cayman
Storage:

Heat shock protein 70s (Hsp70s) are abundant and stress-inducible 70 kDa molecular chaperone proteins encoded by a highly conserved, multigene family.{15480} They are monomeric proteins that can be divided into two functional domains: an N-terminal ATPase domain and a substrate binding domain that contains a highly conserved EEVD motif at its C-terminus. Hsp70s are found in the cytosol, nuclei, endoplasmic reticulum, mitochondria, and chloroplasts of eukaryotes, as well as in bacteria. They function as molecular chaperones that assist in a wide range of cellular processes, including refolding of aggregated or misfolded proteins, co- and post-translational folding and assembly of nascent peptides, membrane translocation of secretory and organellar proteins, controlling activity of regulatory nuclear receptors, kinases and transcription factors, as well as cooperativity with the Hsp90 chaperone system in eukaryotes.{36132} The Hsp70 chaperone cycle is ATP-dependent and initiated by transient interaction of the Hsp70 substrate binding domain with hydrophobic regions within a peptide or protein. It consists of an alteration between the low-affinity ATP-bound state with fast rates of substrate exchange and the high-affinity ADP bound state with slow rates of substrate exchange. Hsp70s are subject to a variety of post-translational modifications and their expression is upregulated under conditions of cellular stress and in a variety of disease states. Cayman’s Hsp70 (HspA1A) Polyclonal Antibody can be used for ELISA, Immunofluorescence, Immunohistochemistry, and Western blot applications. The antibody recognizes Hsp70, also known as HspA1A, at ~70 kDa from human samples.  

 

Available on backorder

Add to quotes
SKU: 24532 - 200 µg Category:

Description

Immunogen: Human recombinant protein • Host: Rabbit • Species Reactivity: (+) Human and rat • Applications: ELISA, IF, IHC, and WB

Synonyms: Heat Shock 70 kDa Protein 1A|Heat Shock Protein 70|HSP70-1

Immunogen: Human recombinant protein

Formulation: 200 µg of Hsp70 (HspA1A) Polyclonal Antibody

Isotype:

Applications: ELISA, IF, IHC, and WB

Origin:

Stability: 365 days

Application|ELISA||Application|Immunofluorescence||Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area

Related products