Immunogen: Full length human recombinant Hsp60 (HspD1) protein • Clone designation: 10C3 • Host: Mouse • Cross Reactivity: (-) Hsp27 • Species Reactivity: (+) Human

Hsp60 (HspD1) Monoclonal Antibody (Clone 10C3) – 100 µg

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Cayman
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Heat shock protein 60 (Hsp60), also known as heat shock protein family D member 1 (HspD1), is an approximately 60 kDa protein that functions as a molecular chaperone.{35046} It belongs to the type I subclass of chaperonins and is found in eubacteria, mitochondria, and chloroplasts where its expression is induced by stress. Hsp60 primarily exists as a heptameric ring that it is converted to a tetradecameric double-ring structure in the presence of ATP.{36472} Within mitochondria, it associates with its co-chaperone, Hsp10, to form a barrel-like structure and refold proteins that have been shuttled to the mitochondria in an ATP-dependent manner.{35047,36472} Hsp60 also has extramitochondrial functions such as the production of proinflammatory cytokines in human leukocytes and activation of innate immune receptors.{35048,36473} Hsp60 expression is increased in the serum and saliva of patients with type 2 diabetes mellitus and mutations in HSPD1 lead to neurodegenerative diseases.{35049,36473} Cayman’s Hsp60 (HspD1) Monoclonal Antibody can be used for ELISA, IHC, and WB applications. The antibody recognizes Hsp60 (HspD1) at 61 kDa from human, mouse, and rat samples.  

 

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SKU: 25693 - 100 µg Category:

Description

Immunogen: Full length human recombinant Hsp60 (HspD1) protein • Clone designation: 10C3 • Host: Mouse • Cross Reactivity: (-) Hsp27 • Species Reactivity: (+) Human, mouse, and rat Hsp60 (HspD1) • Isotype: IgG1 • Applications: ELISA, IHC, and WB

Synonyms: 60 kDa Chaperonin|Chaperonin 60|Cpn60|Heat Shock Protein 60|Mitochondrial Matrix Protein P1|P60 Lymphocyte Protein

Immunogen: Full length human recombinant Hsp60 (HspD1) protein

Formulation: 100 µg of protein G-purified monoclonal antibody

Isotype: IgG1

Applications: ELISA , IHC, and WB

Origin:

Stability: 365 days

Application|ELISA||Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cell Biology|Cellular Chaperones||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Neuroscience|Neurodegenerative Disorders

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