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Histone H3K9Me2 Polyclonal Antibody – 1 ea

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Cayman
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Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.{57056} It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination.{57056,53978} Dimethylation of histone H3 at lysine 9 (H3K9Me2) is associated with transcriptional repression.{48220} Heterochromatin protein 1-α (HP1-α), HP1-β, and HP1-γ selectively bind histone H3 N-terminal peptides containing dimethylated lysine 9 over unmodified lysine 9.{20846} High nuclear levels of H3K9Me2 in tumor tissue are associated with decreased disease-specific and disease-free survival in patients with oral and oropharyngeal squamous cell carcinoma.{49115} Cayman’s Histone H3K9Me2 Polyclonal Antibody can be used for ELISA.  

 

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SKU: 18199 - 1 ea Category:

Description

Immunogen: Synthetic peptide from human H3K9Me2 (aa 1-30) conjugated to KLH • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) H3K36Me2 (~50%); (-) Unmodified histone H3, H3K9Me1, H3K9Me3 • Applications: ELISA

Synonyms: Dimethylated Histone H3 Lysine 9

Immunogen: Synthetic peptide from human H3K9Me2 (aa 1-30) conjugated to KLH

Formulation: 500 µl of peptide affinity-purified antibody

Isotype:

Applications: ELISA

Origin:

Stability: 730 days

Application|ELISA||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Demethylation||Research Area|Epigenetics, Transcription, & Translation|Histones/Histone Peptides|Methylated||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Methylation

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