Immunogen: Synthetic peptide from the N-terminal region of human H3K9Me2 conjugated to KLH • Host: Mouse • Species Reactivity: (+) Human • Cross Reactivity (+) H3K9Me3 (~50%); (-) H3K4Me2

Histone H3K9Me2 Monoclonal Antibody (Clone 9D8) – 100 µg

Brand:
Cayman
Storage:

Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.{57056} It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination.{57056, 53978} Dimethylation of histone H3 at lysine 9 (H3K9Me2) is associated with transcriptional repression.{48220} Heterochromatin protein 1-α (HP1-α), HP1-β, and HP1-γ selectively bind histone H3 N-terminal peptides containing dimethylated lysine 9 over unmodified lysine 9.{20846} High nuclear levels of H3K9Me2 in tumor tissue are associated with decreased disease-specific and disease-free survival in patients with oral and oropharyngeal squamous cell carcinoma.{49115} Cayman’s Histone H3K9Me2 Monoclonal Antibody (Clone 9D8) can be used for ELISA and flow cytometry (FC) applications.  

 

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SKU: 18072 - 100 µg Category:

Description

Immunogen: Synthetic peptide from the N-terminal region of human H3K9Me2 conjugated to KLH • Host: Mouse • Species Reactivity: (+) Human • Cross Reactivity (+) H3K9Me3 (~50%); (-) H3K4Me2, H3K27Me2, H3K36Me2, H3K4Me1 • Applications: ELISA, FC

Synonyms: Dimethylated Histone H3 Lysine 9|Histone H3 containing dimethylated lysine 9

Immunogen: Synthetic peptide from the N-terminal region of human H3K9Me2 conjugated to KLH

Formulation: 100 µg of protein G-purified antibody

Isotype: IgG2bκ

Applications: ELISA, FC

Origin:

Stability: 365 days

Application|ELISA||Application|Flow Cytometry||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Demethylation||Research Area|Epigenetics, Transcription, & Translation|Histones/Histone Peptides|Methylated||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Methylation

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