Immunogen: Peptide corresponding to H3K9Me2/K14Ac • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) H3K9Me2/K14Ac; (-) Unmodified histone H3

Histone H3K9Me2/K14Ac Monoclonal Antibody – 100 µg

Brand:
Cayman
Storage:

Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.{57056} It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination.{57056,53978} Dimethylation of histone H3 at lysine 9 (H3K9Me2) is associated with transcriptional repression, whereas acetylation of histone H3 at lysine 14 (H3K14Ac) is associated with transcriptional activation.{48220,42735} H3K9Me2/K14Ac levels are increased in mouse differentiated embryonic stem cells (ESCs) compared with undifferentiated ESCs.{58041} Altered H3K9Me2/K14Ac levels have been found in tumor biopsies from patients with HER2+, triple-negative, luminal A-like, or luminal B-like breast cancer.{58042} Cayman’s Histone H3K9Me2/K14Ac Monoclonal Antibody recognizes histone H3 only when modified by both dimethylation at K9 and acetylation at K14. This antibody can be used for multiplex-based assay and Western blot (WB) applications.  

 

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SKU: 32152 - 100 µg Category:

Description

Immunogen: Peptide corresponding to H3K9Me2/K14Ac • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) H3K9Me2/K14Ac; (-) Unmodified histone H3, H3K9Me1, H3K9Me2, H3K9Me3, H3K14Ac, H3K14Me2 • Applications: Multiplex-based assays and WB

Synonyms:

Immunogen: Peptide corresponding to H3K9Me2/K14Ac

Formulation: 100 µg of Protein A affinity-purified monoclonal antibody

Isotype: IgG

Applications: Multiplex-based assays and WB

Origin:

Stability: 365 days

Application|Multiplex||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Demethylation||Research Area|Epigenetics, Transcription, & Translation|Histones/Histone Peptides|Acetylated||Research Area|Epigenetics, Transcription, & Translation|Histones/Histone Peptides|Methylated||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Acetylation||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Methylation

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