Antigen: human • Host: mouse • Cross Reactivity: (+) H3K4Me (~50%)

Histone H3K4Me2 Monoclonal Antibody – 100 µg

Brand:
Cayman
Storage:

Histones are nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. The basic structure is a 146 bp strand of DNA wrapped around a histone octamer containing pairs of the four core histones (H2A, H2B, H3, and H4). Histones are subjected to numerous post-translational modifications including methylation. Histone lysine methylation is an important post-translational modification linked to diverse biological pathways including gene transcription, heterochromatin maintenance, and double-stranded DNA break repair.{20250} Most lysine methylation events are carried out by a SET domain-containing HMTase, and methylation at lysine 4 of histone 3 (H3K4) is an evolutionarily conserved modification associated with transcriptionally active chromatin.{19551,20252} The SET1/MLL (KMT2) family of methyltransferases is the principal enzyme family responsible for H3K4 methylations.{19551,19556} The WDR5/RbBP5/Ash21/DPY-30 subcomplex is required for the H3K4 dimethylation activity of the MLL1 core complex.{20268} Cayman’s Histone H3K4Me2 Monoclonal Antibody detects dimethylated histone H3 and does not detect unmodified histone H3.  

 

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SKU: 14137 - 100 µg Category:

Description

Antigen: human • Host: mouse • Cross Reactivity: (+) H3K4Me (~50%), H3K27Me2 (~25%); (-) H3K9Me2, H3K36Me2, H3K4Me3 • Species Reactivity: (+) human • Isotype: IgG2aκ • Application(s): FC and WB

Synonyms: Histone H3 containing dimethylated lysine 4

Immunogen: Synthetic peptide from the N terminal region of human Histone H3 (di-methyl K4) conjugated to KLH.

Formulation: 100 µg of protein G-purified antibody

Isotype: IgG2aκ

Applications: FC and WB

Origin:

Stability: 730 days

Application|Flow Cytometry||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Epigenetics, Transcription, & Translation|Histones/Histone Peptides|Acetylated||Research Area|Epigenetics, Transcription, & Translation|Histones/Histone Peptides|Methylated||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Acetylation||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Methylation

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