Description
Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.{57056} It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination.{57056,53978} Monomethylation of histone H3 at lysine 4 (H3K4Me1) is found at active and primed enhancer regions of gene promoters and H3K4Me1-containing nucleosomes are more efficiently remodeled by the chromatin-remodeling complex BAF than unmarked nucleosomes.{48250,48251} It is also enriched at CpG sites associated with aging in stem and differentiated cells.{48252} Cayman’s Histone H3K4Me1 Monoclonal Antibody can be used for chromatin immunoprecipitation (ChIP), ELISA, immunocytochemistry (ICC), multiplex-based assay, and Western blot (WB) applications.
Synonyms: Monomethylated Histone H3 Lysine 4
Immunogen: Peptide corresponding to H3K4Me1
Formulation: 100 µg of protein A-affinity purified monoclonal antibody
Isotype: IgG
Applications: ChIP, ELISA, ICC, multiplex-based assay, WB
Origin:
Stability: 365 days
Application|ELISA||Application|Immunocytochemistry||Application|Immunoprecipitation||Application|Multiplex||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cell Biology|Stem Cell Research||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Demethylation||Research Area|Epigenetics, Transcription, & Translation|Histones/Histone Peptides|Methylated||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Methylation
