Immunogen: Synthetic peptide from human histone H3 amino acids 26-44 (dimethyl K36) conjugated to KLH • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) Histone H3 amino acids 26-44 (~10%)

Histone H3K36Me2 Polyclonal Antibody – 1 ea

Brand:
Cayman
Storage:

Histone H3 is a nuclear protein and a component of the nucleosome core that is essential for organizing genomic DNA in eukaryotic nuclei.{57055} It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various posttranslational modifications, including mono-, di-, and trimethylation at histone H3 lysine 36 (H3K36). Dimethylation of H3K36 is catalyzed by SET domain-containing histone methyltransferases including SET2, HYPB, NSD1, and ASH1L, and mutation of these methyltransferases is associated with various diseases, including multiple myeloma and Sotos syndrome.{57055,48281,20289} H3K36Me2 is enriched at the coding regions of genes and correlates with the initiation, but not maintenance, of active transcription, heterochromatin maintenance, and DNA break repair.{48280,48281,20250} Cayman’s Histone H3K36Me2 Polyclonal Antibody can be used for ELISA and Western blot applications. It detects H3K36Me2 at ~16 kDa from human samples.  

 

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SKU: 18200 - 1 ea Category:

Description

Immunogen: Synthetic peptide from human histone H3 amino acids 26-44 (dimethyl K36) conjugated to KLH • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) Histone H3 amino acids 26-44 (~10%), (+) Histone H3 dimethylated at lysine 9 (~10%), (+) Histone H3 monomethylated at lysine 36 (~10%), (+) Histone H3 trimethylated at lysine 36 (~10%) • Applications: ELISA and WB • MW = ~16 kDa

Synonyms: Histone H3 containing dimethylated lysine 36

Immunogen: Synthetic peptide from human histone H3 amino acids 26-44 (dimethyl K36) conjugated to KLH

Formulation: 500 μl of peptide affinity-purified antibody

Isotype:

Applications: ELISA and WB

Origin:

Stability: 365 days

Application|ELISA||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Demethylation||Research Area|Epigenetics, Transcription, & Translation|Histones/Histone Peptides|Methylated||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Methylation

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