Description
Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.{57056} It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination.{57056,53978} Acetylation of histone H3 at lysine 18 (H3K18Ac) by histone acetyltransferases (HATs) is associated with active gene transcription, whereas deacetylation of H3K18Ac by histone deacetylases (HDACs), including SIRT7, induces transcriptional repression.{21963} Tumor H3K18Ac hypoacetylation is associated with poor prognosis and increased risk of tumor recurrence in patients with lung adenocarcinoma or kidney clear cell carcinoma.{57202} Cayman’s Histone H3K18Ac Monoclonal Antibody can be used for chromatin immunoprecipitation (ChIP), ELISA, immunocytochemistry (ICC), immunohistochemistry (IHC), multiplex-based assay, and Western blot (WB) applications.
Synonyms: Acetylated Histone H3 Lysine 18
Immunogen: Peptide corresponding to H3K18Ac
Formulation: 100 µg of protein A-affinity purified monoclonal antibody
Isotype: IgG
Applications: ChIP, ELISA, ICC, IHC, multiplex-based assays, WB
Origin:
Stability: 365 days
Application|ELISA||Application|Immunocytochemistry||Application|Immunohistochemistry||Application|Immunoprecipitation||Application|Multiplex||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation||Research Area|Epigenetics, Transcription, & Translation|Histones/Histone Peptides|Acetylated||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Acetylation
