Immunogen: Recombinant histone H3 protein • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (-) H2A

Histone H3 Polyclonal Antibody – 500 µg

Brand:
Cayman
Storage:

Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.{57056} It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination.{57056,53978} Histone H3 PTMs function as epigenetic regulators of gene transcription by affecting chromatin structure and providing binding sites for many transcription factors, thus regulating several cellular functions including gene expression, cell cycle, and DNA replication and repair.{57056,56203} Differential methylation of histone H3 at various lysine residues is catalyzed by SET domain-containing methyltransferases and marks sites of transcriptional activation or repression.{57056} Citrullination of histone H3 by protein arginine deiminase 4 (PAD4; Item Nos. 10500 | 25915 | 28910) or PAD2 (Item No. 10785) induces the release of neutrophil extracellular traps (NETs), a network of decondensed DNA and intracellular proteins secreted by neutrophils as a pathogen defense mechanism.{52711,52712} Histone H3 mutations have been found in patients with diffuse intrinsic pontine glioma, leukemia, or chondroblastoma.{52713,49724} Cayman’s Histone H3 Polyclonal Antibody can be used for ELISA, flow cytometry (FC), immunoprecipitation (IP), and Western blot (WB) applications. The antibody recognizes histone H3 at 15.5 kDa from human samples.  

 

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SKU: 13781 - 500 µg Category:

Description

Immunogen: Recombinant histone H3 protein • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (-) H2A, H2B, H4 • Applications: ELISA, FC, IP, WB • MW = 15.5 kDa

Synonyms: H3

Immunogen: Recombinant Histone H3 Protein

Formulation: This vial contains 500 µg protein A-purified IgG

Isotype:

Applications: ELISA, FC, IP, and WB

Origin:

Stability: 365 days

Application|ELISA||Application|Flow Cytometry||Application|Immunoprecipitation||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Epigenetics, Transcription, & Translation|Histones/Histone Peptides||Research Area|Immunology & Inflammation|Innate Immunity|NETosis

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