Immunogen: Synthetic peptide from the C-terminal region of human HHATL • Host: Rabbit • Species Reactivity: (+) Human HHATL • Applications: FC

HHATL Polyclonal Antibody – 1 ea

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Cayman
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Hedgehog acyltransferase-like (HHATL) is the mammalian homolog of yeast Gup1 that is encoded by the HHATL gene in humans.{53526} HHATL is a membrane-bound O-acyltransferase (MBOAT) superfamily member and contains multiple transmembrane domains common to this family but lacks acyltransferase function due to a single amino acid substitution of histidine for leucine at position 447.{53526,27302} It is localized to the endoplasmic reticulum (ER) and is expressed in the heart, skeletal muscle, and brain.{53526,27300,53527} HHATL colocalizes with sonic hedgehog (Shh) and is a negative regulator of Shh N-terminal palmitoylation, a post-translational modification that is critical for Shh signaling in neural development and embryogenesis.{27300} Hhatl-/- neonatal mice fail to develop proper suckling ability, leading to malnutrition and death by postnatal day 14.{53528} HHATL expression is decreased in six nasopharyngeal carcinoma cell lines, as well as in tissue isolated from patients with nasopharyngeal carcinoma or skin squamous cell carcinoma.{53529,53530} Cayman’s HHATL Polyclonal Antibody can be used for flow cytometry (FC), immunofluorescence (IF), and Western blot applications. The antibody recognizes HHATL at ~60 kDa from human samples.  

 

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SKU: 15648 - 1 ea Category:

Description

Immunogen: Synthetic peptide from the C-terminal region of human HHATL • Host: Rabbit • Species Reactivity: (+) Human HHATL • Applications: FC, IF, WB • MW = ~60 kDa

Synonyms: C3orf3|Glycerol Uptake Transporter Homolog|GUP1|Hedgehog Acyltransferase-like Protein|KIAA1173|MBOAT3|MSTP002|OACT3|Protein-Cysteine N-Palmitoyltransferase HHAT-like Protein

Immunogen: Synthetic peptide from the C-terminal region of human HHAT

Formulation: 500 µl of Peptide-affinity purified antibody

Isotype:

Applications: FC, IF, and WB

Origin:

Stability: 365 days

Application|Flow Cytometry||Application|Immunofluorescence||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cardiovascular System|Heart||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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