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GRP94 Monoclonal Antibody (Clone 9G10) – 200 µg

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Cayman
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Glucose regulated protein 94 (GRP94) is a constitutively expressed endoplasmic reticulum (ER) lumenal protein that is up-regulated in response to cellular stress such as heat shock, oxidative stress or glucose depletion. GRP94 is thought to play a role in protein translocation to the ER, in their subsequent folding and assembly, and in regulating protein secretion.{15669} GRP94 also plays a role in antigen presentation by accessing the endogenous pathway and eliciting specific cytotoxic T lymphocyte (CTL) responses to chaperone bound peptides via the major histocompatibility complex (MHC) class I pathway.{15670} GRP94 is a member of the Hsp90 family of stress proteins and shares sequence homology with its cytosolic equivalent, Hsp90.{15671} Both Hsp90 and GRP94 are calcium binding proteins.{15672} Despite sharing 50% sequence homology over its N domains and complete conservation in its ligand binding domains with Hsp90, GRP94, and Hsp90 differ in their interactions with regulatory ligands as GRP94 has weak ATP binding and hydrolysis activity.{15673} GRP94 exists as a homodimer and the two subunits interact at two distinct intermolecular sites, C-terminal dimerization domains and the N-terminal interacts with the middle domain of opposing subunits.{15674} GRP94 contains a carboxy terminal KDEL (Lys-Asp-Glu-Leu) sequence which is believed to aid in its retention in the ER.{15675}  

 

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SKU: 10011424 - 200 µg Category:

Description

Immunogen: Purified GRP94 isolated from chicken oviducts · Host: rat, clone 9G10 · Species Reactivity: (+) Human, African clawed frog (X. laevis), bovine, chicken, dog, guinea pig (C. porcellus), hamster, horse, monkey, mouse, pig, rabbit, rat, and sheep GPR94 · Applications: FC, ICC/IF, IP, and WB · Isotype: IgG2a

Synonyms: Glucose Regulated Protein 94|GP94

Immunogen: Purified GRP94 isolated from chicken oviducts

Formulation: Protein G purified IgG2a at a concentration of 1 mg/ml

Isotype: IgG2a

Applications: FC, ICC/IF, IP, and WB

Origin: Animal/Rat

Stability: 365 days

Application|Flow Cytometry||Application|Immunoprecipitation||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|ER Protein Folding||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism

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