Immunogen: Full length human recombinant GRP78 protein • Host: Mouse • Species reactivity: (+) Human

GRP78 Monoclonal Antibody (Clone 7D8) – 100 µg

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Cayman
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Glucose-regulated protein 78 kDa (GRP78), also known as heat shock 70 kDa protein 5 (HspA5) and immunoglobulin heavy chain-binding protein (BiP), is a glucose-regulated protein that is constitutively expressed in the lumen of the endoplasmic reticulum (ER).{36130,36131,36132} It is composed of two functional domains, an N-terminal nucleotide-binding domain that contains an ATP catalytic site and a C-terminal substrate binding domain that binds hydrophobic polypeptides.{36134} GRP78 functions as a molecular chaperone, assisting in the translocation of polypeptides from the cytosol into the ER, folding of nascent polypeptides, as well as refolding and preventing aggregation of misfolded proteins. It also plays a role in the ER-assisted degradation (ERAD) and unfolded protein response (UPR) pathways.{36137,36136} GRP78 chaperone activity is driven by an ATPase cycle that is regulated by ER-localized DnaJ-like protein co-factors and nuclear exchange factors.{36133,36135} Expression of GRP78 is upregulated in response to ER stress caused by viral and bacterial infections as well as various cancers.{36139} ER stress can also promote extracellular secretion of GRP78 leading to its anti-inflammatory functions in immunity.{36138} Cayman’s GRP78 Monoclonal Antibody can be used for Western blot and ELISA applications. The antibody recognizes GRP78 at ~72 kDa from human, mouse, and rat samples.  

 

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SKU: 25690 - 100 µg Category:

Description

Immunogen: Full length human recombinant GRP78 protein • Host: Mouse • Species reactivity: (+) Human, Mouse, Rat • Cross reactivity: (-) Hsp70 • Applications: ELISA,IHC, WB

Synonyms: 78 kDa Glucose-regulated Protein|Binding-immunoglobulin Protein|BiP|Endoplasmic Reticulum Chaperone BiP|Heat Shock Protein 70 Family Protein 5|Heat Shock Protein Family A Member 5|Hsp70 Family Protein 5|Immunoglobulin Heavy Chain-binding Protein

Immunogen: Full length human recombinant GRP78 protein

Formulation: 100 µg of protein G-purified monoclonal antibody

Isotype: IgG1

Applications: ELISA, IHC, and WB

Origin:

Stability: 365 days

Application|ELISA||Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cancer||Research Area|Cell Biology|Cellular Chaperones||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|ER Protein Folding

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