Description
GABAA receptors are ligand-gated chloride channels that mediate the effects of the inhibitory neurotransmitter GABA in the CNS.{46949,46950} They are postsynaptic heteropentameric receptors that contain protein subunits from the following isoforms: α1-6, β1-4, γ1-3, δ, ε, π, θ, and ρ1-3, arranged around a central pore. Phasic inhibitory synaptic transmission is regulated by α1β2γ2 subunit-containing GABAA receptors, the major isoform found in the brain.{46950,46951} The β subunit of GABAA receptors interfaces with an α subunit to form the GABA binding site that initiates GABA-induced action potentials and forms the benzodiazepine binding site with the γ subunit. Phosphorylation of the β1 subunit by PKA or PKC inhibits binding of the β1 subunit with the clathrin adaptor protein AP2 and reduces GABAA receptor endocytosis.{55097} Mice expressing mutations in Gabrb1, which encodes the β1 subunit isoform, have increased GABAA receptor-mediated tonic inhibition in the nucleus accumbens and increased alcohol consumption compared to wild-type mice.{55212} SNPs in GABRB1 are associated with increased impulsivity and reward sensitivity in human adolescents.{55217} Cayman’s GABAA Receptor β1 Polyclonal Antibody can be used for Western blot (WB) applications. The antibody recognizes the GABAA receptor β1 subunit at approximately 55 kDa from mouse and rat samples.
Synonyms: GABAA Receptor Subunit β1|GABRB2|Gamma-aminobutyric Acid (GABA) A Receptor, β1|Gamma-aminobutyric Acid Receptor Subunit β1
Immunogen: Fusion protein from the cytoplasmic loop of the β1 subunit of the rat GABAA receptor
Formulation: 100 µl of affinity-purified polyclonal antibody from pooled serum
Isotype:
Applications: WB
Origin:
Stability: 365 days
Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research
