Immunogen: Fusion protein from the cytoplasmic loop of the β1 subunit of the rat GABAA receptor • Host: Rabbit • Species Reactivity: (+) Mouse

GABAA Receptor β1 Subunit Polyclonal Antibody – 100 µl

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Cayman
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GABAA receptors are ligand-gated chloride channels that mediate the effects of the inhibitory neurotransmitter GABA in the CNS.{46949,46950} They are postsynaptic heteropentameric receptors that contain protein subunits from the following isoforms: α1-6, β1-4, γ1-3, δ, ε, π, θ, and ρ1-3, arranged around a central pore. Phasic inhibitory synaptic transmission is regulated by α1β2γ2 subunit-containing GABAA receptors, the major isoform found in the brain.{46950,46951} The β subunit of GABAA receptors interfaces with an α subunit to form the GABA binding site that initiates GABA-induced action potentials and forms the benzodiazepine binding site with the γ subunit. Phosphorylation of the β1 subunit by PKA or PKC inhibits binding of the β1 subunit with the clathrin adaptor protein AP2 and reduces GABAA receptor endocytosis.{55097} Mice expressing mutations in Gabrb1, which encodes the β1 subunit isoform, have increased GABAA receptor-mediated tonic inhibition in the nucleus accumbens and increased alcohol consumption compared to wild-type mice.{55212} SNPs in GABRB1 are associated with increased impulsivity and reward sensitivity in human adolescents.{55217} Cayman’s GABAA Receptor β1 Polyclonal Antibody can be used for Western blot (WB) applications. The antibody recognizes the GABAA receptor β1 subunit at approximately 55 kDa from mouse and rat samples.  

 

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SKU: 29273 - 100 µl Category:

Description

Immunogen: Fusion protein from the cytoplasmic loop of the β1 subunit of the rat GABAA receptor • Host: Rabbit • Species Reactivity: (+) Mouse, Rat • Applications: WB • MW = ~55 kDa

Synonyms: GABAA Receptor Subunit β1|GABRB2|Gamma-aminobutyric Acid (GABA) A Receptor, β1|Gamma-aminobutyric Acid Receptor Subunit β1

Immunogen: Fusion protein from the cytoplasmic loop of the β1 subunit of the rat GABAA receptor

Formulation: 100 µl of affinity-purified polyclonal antibody from pooled serum

Isotype:

Applications: WB

Origin:

Stability: 365 days

Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research

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