Description
GPR43 is a G protein-coupled receptor activated by short chain fatty acids (SCFAs).{25541,25605,25606} Several SCFAs have the potential to bind and activate GPR43, including acetate, formate, propionate, and butyrate.{25605} GPR43 couples through the Pertussis toxin-sensitive Gi/o and the pertussis toxin-insensitive Gq protein families and its expression has been described in enteroendocrine cells and neutrophils.{25606,25605} The activation of GPR43 induces an increase in intracellular Ca2+, ERK1/2 activation, and a decrease in intracellular cAMP.{25606,25605,25541} Activation of GPR43 may be involved in intestinal inflammation. The predicted size of GPR43 is 37 kDa. Cayman’s GPR43 (Internal) Polyclonal Antibody detects a 37 kDa band in cell lysates.
Synonyms: Free Fatty Acid Receptor 2|G Protein-Coupled Receptor 43
Immunogen: peptide from the internal region of human GPR43
Formulation: Peptide affinity-purified IgG lyophilized from TBS, pH 7.4, containing 5 mg/ml BSA
Isotype:
Applications: FC, IF, and WB
Origin:
Stability: 730 days
Application|Flow Cytometry||Application|Immunofluorescence||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Fatty Acids
