Host: Mouse • Species Reactivity: (+) Human and bovine DNA • Cross Reactivity: (+) Single- and double-stranded DNA

DNA Monoclonal Antibody (Clone 4E9) – 100 µg

Brand:
Cayman
Storage:

Activated neutrophils produce neutrophil extracellular traps (NETs), antimicrobial snares that are comprised of granular and cytoplasmic proteins, as well as decondensed nuclear DNA associated with histone proteins.{53539} NET degradation is impaired in patients with systemic lupus erythematosus (SLE), allowing for production of autoantibodies against NET components, including dsDNA. The NZBWF1 mouse model of SLE similarly produces autoantibodies against chromatin, dsDNA, and ssDNA.{53540,53541} Cayman’s DNA Monoclonal Antibody (Clone 4E9) was developed by fusing the spleen of a non-immunized NZBWF1 mouse with a mouse myeloma cell line and can be used for immunohistochemistry (IHC), immunofluorescence (IF), and ELISA applications. The antibody recognizes ssDNA and dsDNA, including nuclear DNA, from human and bovine samples.  

 

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SKU: 30185 - 100 µg Category:

Description

Host: Mouse • Species Reactivity: (+) Human and bovine DNA • Cross Reactivity: (+) Single- and double-stranded DNA, nuclei; (–) Reduced protein lysate, histone • Applications: IHC, IF, ELISA

Synonyms: DNA Antibody|ss/dsDNA Monoclonal Antibody

Immunogen:

Formulation: 100 µg of protein G-purified monoclonal antibody

Isotype: IgG1

Applications: IHC, IF, ELISA

Origin:

Stability: 365 days

Application|ELISA||Application|Immunofluorescence||Application|Immunohistochemistry||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Immunology & Inflammation|Autoimmunity|Lupus||Research Area|Immunology & Inflammation|Innate Immunity|NETosis

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