Immunogen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr34 site of rat DARPP-32 • Host: Rabbit • Species Reactivity: (+) Mouse

DARPP-32 (Phospho-Thr34) Polyclonal Antibody – 100 µl

Brand:
Cayman
Storage:

Dopamine and cAMP-regulated phosphoprotein of molecular weight 32 kDa (DARPP-32) is a member of the protein phosphatase inhibitor 1 family and is encoded by the PPP1R1B gene in humans.{53496} It is primarily expressed in medium spiny neurons of dopamine-innervated brain regions and is localized to the cytoplasm.{53497} DARPP-32 contains multiple phosphorylation sites that allow it to function as a central regulator and integrator of signaling cascades induced by a variety of neurotransmitters, neuropeptides, and psychostimulatory agents. It also contains a protein phosphatase 1 (PP1) binding domain.{53498} DARPP-32, when phosphorylated at the threonine in position 34 (phospho-Thr34) by PKA, is a PP1 inhibitor.{53496} Phosphorylation of DARPP-32 at Thr34 is induced by GABA in rat striatal and substantia nigra slices.{53499} Mice expressing a point mutation of Thr34 (T34A) in DARPP-32, which abolishes its phosphorylation, have reduced cocaine-induced conditioned place preference compared to wild-type mice.{53500} DARPP-32 (phospho-Thr34) levels are decreased in postmortem-derived prefrontal cortex from individuals with schizophrenia.{53501} Cayman’s DARPP-32 (Phospho-Thr34) Polyclonal Antibody can be used for Western blot (WB) applications. The antibody recognizes DARPP-32 (phospho-Thr34) at approximately 32 kDa from mouse and rat samples.  

 

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SKU: 10603 - 100 µl Category:

Description

Immunogen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr34 site of rat DARPP-32 • Host: Rabbit • Species Reactivity: (+) Mouse, Rat • Cross Reactivity: (+) DARPP-32 (phospho-Thr34); (-) Unphosphorylated DARPP-32 • Applications: WB • MW = ~32 kDa

Synonyms:

Immunogen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr34 site of rat DARPP-32

Formulation: 100 µl of Affinity-purified rabbit polyclonal antibody

Isotype:

Applications: WB

Origin:

Stability: 365 days

Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cell Biology|Cell Signaling|cAMP Signaling||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis||Research Area|Neuroscience|Neurodegenerative Disorders

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