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CysLT1 Receptor Polyclonal FITC Antibody – 500 µl

Brand:
Cayman
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The cysteinyl leukotrienes (CysLTs; LTC4, LTD4, and LTE4) contract airway and pulmonary vascular smooth muscle, increase vascular permeability, and stimulate mucus secretion, thereby playing a major role in asthma.{3956,2069,3483,4157} LTC4, LTD4, and LTE4 mediate their actions via at least two receptors designated CysLT1 and CysLT2.{3956} Cloning of the human CysLT1 receptor reveals it is a 337 amino acid protein with a calculated molecular mass of 38,549.{7174} The rank order of binding for leukotrienes to the cloned receptor, as determined using a radioligand binding assay, is LTD4 >> LTC4 = LTE4 >> LTB4.{7174} The mRNA for the human CysLT1 receptor is expressed in spleen and peripheral blood leukocytes with smaller amounts in lung, placenta, and small intestine. Immunohistochemical studies reveal the receptor is expressed on eosinophils, mast cells, macrophages, neutrophils, and vascular endothelial cells in the nasal mucosa.{10310}  

 

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SKU: 14713 - 500 µl Category:

Description

Immunogen: Synthetic peptide from the C-terminal region of CysLT1 receptor • Host: Rabbit • Species Reactivity: (+) Human and mouse CysLT1 receptor • Application(s): FC • The CysLT1 receptor binds LTD4, LTC4, and LTE4, playing a major role in asthma by facillitating airway and pulmonary vascular smooth muscle contraction, increased vascular permeability, and stimulating mucus secretion. The mRNA for the human CysLT1 receptor is expressed in spleen and peripheral blood leukocytes with smaller amounts in lung, placenta, and small intestine.

Synonyms: Cysteinyl Leukotriene Receptor 1

Immunogen: Synthetic peptide from the C-terminal region of CysLT1 receptor

Formulation: 500 µl peptide affinity-purified, fluorescein-labeled polyclonal antibody

Isotype:

Applications: FC

Origin:

Stability: 365 days

Application|Flow Cytometry||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cardiovascular System|Vasculature|Endothelium||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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