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Cu/Zn SOD (rat) Polyclonal Antibody – 100 µl

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Cayman
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Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body.{15491} It works by catalyzing the dismutation of the superoxide radical O2- to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase.{15490,15493} In general, SODs play a major role in antioxidant defense mechanisms.{15492} There are two main types of SOD in mammalian cells. One form, SOD1, contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cystines forming an intra-subunit disulphide bridge.{15491} The second form, SOD2, is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form, SOD3 or EC-SOD, is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDa and it exists only in the extra-cellular space.{15494} SOD3 can also be distinguished by its heparin-binding capacity.{15489}  

 

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SKU: 10011387 - 100 µl Category:

Description

Antigen: rat Cu/Zn SOD · Host: rabbit · Cross Reactivity: (+) human, mouse, bovine, and rat Cu/Zn SOD · Applications: IHC, IP, and WB • SOD1 contains Cu and Zn ions as a homodimer and exists in the cytoplasm where it plays a major role in antioxidant defense mechanisms by catalyzing the dismutation of the superoxide radical O2- to O2 and H2O2.

Synonyms: Cu/Zn Superoxide Dismutase|SOD1

Immunogen: rat Cu/Zn SOD

Formulation: Affinity-purified antibody at a concentration of 1 mg/ml in PBS, pH 7.0, containing 0.1% sodium azide and 50% glycerol

Isotype:

Applications: WB, IP, and IHC

Origin: Animal/Rabbit

Stability: 365 days

Application|Immunohistochemistry||Application|Immunoprecipitation||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase

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