COX-1 (ovine) Inhibitor Screening Assay Kit – 96 wells

Brand:
Cayman
Storage:
-80

COX-1 and COX-2 catalyze the production of the prostaglandin (PG) and thromboxane precursor PGH2. COX-2 is primarily responsible for the biosynthesis of PGs under acute inflammatory conditions. The COX-1 (ovine) Inhibitor Screening Assay measures PGF2α that is produced by SnCl2 reduction of COX-1-derived PGH2. PGF2α is quantified via enzyme immunoassay (EIA) using a broadly specific antiserum that binds to all the major PG compounds. This assay includes ovine COX-1 and is an excellent tool which can be used for general inhibitor screening, or to eliminate false positive leads generated by less specific methods.  

 

Available on backorder

SKU: 701090 - 96 wells Category:

Description

COX-1 and COX-2 catalyze the production of the PG and TX precursor PGH2. COX-2 is primarily responsible for the biosynthesis of PGs under acute inflammatory conditions. The COX-1 (ovine) Inhibitor Screening Assay measures PGF2α that is produced by SnCl2 reduction of COX-1-derived PGH2. PGF2α is quantified via EIA using a broadly specific antiserum that binds to all the major PG compounds. This assay includes ovine COX-1 and is an excellent tool which can be used for general inhibitor screening, or to eliminate false positive leads generated by less specific methods.


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Synonyms:  Cyclooxygenase 1

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Origin: Animal/Sheep


Product Type|Assay Kits|Colorimetric Assays||Product Type|Assay Kits|Inhibitor Screening Assays||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway