Immunogen: Citrullinated peptide sequence from an internal region of human vimentin • Clone Designation: 12G11 • Host: Mouse • Cross Reactivity: (+) Citrullinated vimentin; (-) Unmodified protein • Species Reactivity: (+) Human; other species not tested • Isotype: IgG1 • Applications: ELISA and WB

Citrullinated Vimentin Monoclonal Antibody (Clone 12G11) – 100 µg

Brand:
Cayman
Storage:

Vimentin is a cytoskeleton intermediate filament protein present in cells of mesenchymal origin, including leukocytes, endothelial cells, and smooth muscle cells. It is subject to citrullination by peptidyl arginine deiminase 2 (PAD2; Item No. 10785) under high calcium concentrations, which can occur during macrophage apoptosis.{31884} Citrullinated vimentin has been shown to have a role in the production of anti-citrullinated protein antibodies (ACPAs).{31884,31883,55252} ACPAs against citrullinated proteins, such as vimentin, are considered to be highly specific markers for rheumatoid arthritis and other autoimmune diseases.{31883,55252} Cayman’s Citrullinated Vimentin Monoclonal Antibody (Clone 12G11) can be used for Western blot and ELISA applications. The antibody recognizes citrullinated vimentin at ~54 kDa from human samples.  

 

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SKU: 22054 - 100 µg Category:

Description

Immunogen: Citrullinated peptide sequence from an internal region of human vimentin • Clone Designation: 12G11 • Host: Mouse • Cross Reactivity: (+) Citrullinated vimentin; (-) Unmodified protein • Species Reactivity: (+) Human; other species not tested • Isotype: IgG1 • Applications: ELISA and WB,

Synonyms:

Immunogen: Citrullinated peptide sequence from an internal region of human vimentin

Formulation: 100 µg of protein G-purified antibody

Isotype: IgG1

Applications: ELISA and WB

Origin:

Stability: 365 days

Application|ELISA||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Innate Immunity

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