Description
Cayman’s Caspase-4 Inhibitor Screening Assay Kit provides a robust and easy-to-use platform for identifying novel inhibitors of human caspase-4, a major upstream effector of non-canonical inflammasome activation. The assay uses a caspase-4-specific fluorogenic substrate, Ac-LEVD-AFC. Caspase-4 cleaves this substrate generating free AFC, which can be easily quantified using a fluorescence plate reader at excitation and emission wavelengths of 400 and 505 nm, respectively. The potent and reversible caspase-4 inhibitor AC-LEVD-CHO is included as a positive control.
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Application|Fluorescence||Product Type|Assay Kits|Fluorometric Assays||Product Type|Assay Kits|Inhibitor Screening Assays||Research Area|Cell Biology|Cell Death|Pyroptosis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Immunology & Inflammation|Innate Immunity|Sepsis/Shock||Research Area|Neuroscience|Neurodegenerative Disorders
