Description
Apoptosis is associated with many diseases and is induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. Caspase-3 is a key effector caspase in the apoptosis cascade.{7216,6292} The enzyme is efficiently activated by caspase-8, caspase-9, and granzyme B resulting in 17 and 12 kDa active subunits formed from the 34 kDa proenzyme.{7216, 8444} The substrates of caspase-3 are numerous and include pro- and anti-apoptotic proteins, downstream components of the apoptotic machinery (for example, ICAD), as well as structural and homeostatic proteins.{7216,6292} DNA fragmentation and the morphological changes associated with this final stage of apoptosis appears to be dependent upon caspase-3.{6291} Caspase-3 is expressed in a variety of tissues and cells.{8444,8443}
Synonyms: Apopain|CASP3|Cysteine Protease CPP32|Protein Yama|SCA-1|SREBP Cleavage Activity 1
Immunogen: Synthetic peptide from an internal region of human caspase-3
Formulation: 500 µl Peptide affinity-purified polyclonal antibody
Isotype:
Applications: WB and IHC
Origin: Animal/Rabbit
Stability: 365 days
Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases
