Description
Calretinin is a calcium-binding protein and member of the large EF-hand protein family that is encoded by CALB2 in humans.{59515} It is composed of six EF-hand domains, each of which contains two α-helices oriented perpendicular to each other around a calcium-binding domain. Calretinin is expressed in specific neuronal populations, including granule cells of the cerebellum, auditory neurons, and retinal neurons, and is localized to the cytosol where it has a role in the modulation of neuronal excitability. It is also expressed under pathological conditions, particularly in epithelial mesothelioma cells and colon adenocarcinomas. Calb2-/- mice exhibit impaired induction of long-term potentiation following tetanic hippocampal stimulation. Levels of calretinin are increased in the dorsomedial and ventromedial hypothalamic nuclei in aged rats.{59516} Cayman’s Calretinin (N-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.
Synonyms: 29 kDa Calbindin|CAB29|CAL2|Calbindin 2
Immunogen: Peptide from the N-terminal region of human calretinin
Formulation: 100 µl of protein A-affinity purified monoclonal antibody
Isotype: IgG
Applications: IHC and WB
Origin:
Stability: 365 days
Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cancer||Research Area|Neuroscience|Ophthalmology
