Description
c-Fos is a widely expressed nuclear protein and member of the Fos protein family that includes c-Fos, FosB, Fra-1, and Fra-2.{55194} It is a proto-oncogene that contains a leucine zipper motif to facilitate heterodimerization with Jun family proteins, such as c-Jun, to form the transcription factor complex activator protein-1 (AP-1) that has roles in cell proliferation, differentiation, and apoptosis. Expression of c-fos is induced in response to growth factors, tumor promoters, cytokines, and UV radiation.{55194,55195} In neurons, c-fos expression is induced upon depolarization and is widely used as a marker of neuronal activation.{55196} c-fos is also overexpressed in a variety of tumor cells, and transgenic overexpression of c-fos in mice induces formation of chondrosarcomas.{55195,55197} Cayman’s c-Fos Monoclonal Antibody can be used for immunocytochemistry (ICC), immunohistochemistry (IHC), and Western blot (WB) applications. The antibody recognizes c-Fos at approximately 50 kDa from human, bovine, mouse, and rat samples.
Synonyms: AP-1 Transcription Factor Subunit|FBJ Murine Osteosarcoma Viral Oncogene Homolog|Fos Proto-oncogene|Proto-oncogene c-Fos
Immunogen: Recombinant human full-length c-Fos
Formulation: 100 µl of protein G-purified monoclonal antibody
Isotype:
Applications: ICC, IHC, WB
Origin:
Stability: 365 days
Application|Immunocytochemistry||Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cancer|Transcription Factors||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Neuroscience
