For screening a variety of anti-inflammatory compounds; contains ~235 compounds in a 96-well Matrix™ tube rack format as 10 mM stock solutions in DMSO; includes a variety of compounds that inhibit pro-inflammatory cytokine production

Anti-Inflammatory Screening Library – 50 µl

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Cayman
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The Anti-Inflammatory Screening Library consists of 3 plates and contains approximately 235 anti-inflammatory and related compounds in a 96-well Matrix™ tube rack format as 10 mM stock solutions in DMSO. This library includes inhibitors of pro-inflammatory cytokine production, macrophage and T cell activation, cytokine storm receptor signaling, the NLRP3 inflammasome, NF-κB signaling, and kinases involved in canonical and non-canonical inflammatory signaling pathways. It also includes corticosteroids, glucocorticoids, and inhibitors of enzymes involved in inflammatory lipid mediator production and metabolism, such as COX-1 and COX-2, 5-lipoxygenase (5-LO), microsomal prostaglandin E synthase-1 (mPGES-1), cytosolic phospholipase A2 (cPLA2), and soluble epoxide hydrolase (sEH). Additional targets include enzymes and receptors involved in NETosis, coagulation, and platelet aggregation. Please review the product insert for a full list of targets. Stability data is not available for the compounds as supplied in the screening library.  

 

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SKU: 31530 - 50 µl Category:

Description

For screening a variety of anti-inflammatory compounds; contains ~235 compounds in a 96-well Matrix™ tube rack format as 10 mM stock solutions in DMSO; includes a variety of compounds that inhibit pro-inflammatory cytokine production, macrophage and T cell activation, cytokine storm receptor signaling, the NLRP3 inflammasome, NF-κB signaling, kinases, and inflammatory lipid mediator production and metabolism; also includes corticosteroids, glucocorticoids, and inhibitors of NETosis, coagulation, and platelet aggregation.

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Formulation: A 10 mM solution in DMSO

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Applications:

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Stability: 365 days

Application|High-Throughput Screening||Product Type|Biochemicals|Compound Libraries||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Immunosuppressants||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Specialized Pro-Resolving Mediators||Research Area|Immunology & Inflammation|Innate Immunity|NETosis||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways||Research Area|Lipid Biochemistry|Glycerophospholipids|Phospholipases||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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