Immunogen: BSA-conjugated 5-methyl cytosine • Host: Rabbit • Species Reactivity: (+) All species • Cross Reactivity: (+) 5-methyl cytosine in both single-stranded and double-stranded DNA; (-) Non-methylated cytosine

Anti-5-methyl Cytosine Rabbit Monoclonal Antibody (Clone RM231) – 50 µg

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Cayman
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DNA methylation of cytosine to 5-methyl cytosine (5-mC) is an epigenetic mark that is relatively common in both plants and mammals and plays a role in transcriptional and chromatin regulation. In healthy cells, DNA methylation occurs at CpG sites, but CpG islands are generally not modified. However, tumor cells show an increase in CpG island methylation and a decrease in individual CpG sites.{27017} This ‘hypo-methylation’ can lead to aberrant activation of genes. Anti-5-methyl Cytosine Rabbit Monoclonal Antibody (Clone RM231) is a probe for immunochemical detection of 5-methyl cytosine by methylated DNA immunoprecipitation, IHC, ICC, ELISA, or dot blot.  

 

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SKU: 20722 - 50 µg Category:

Description

Immunogen: BSA-conjugated 5-methyl cytosine • Host: Rabbit • Species Reactivity: (+) All species • Cross Reactivity: (+) 5-methyl cytosine in both single-stranded and double-stranded DNA; (-) Non-methylated cytosine, hydroxymethyl cytosine in DNA • Applications: Dot blot, ELISA, ICC, IHC, MeDIP • A probe for immunochemical detection of 5-methyl cytosine by methylated DNA immunoprecipitation, IHC, ICC, ELISA, or dot blot

Synonyms: 5-mC

Immunogen: BSA-conjugated 5-methyl cytosine

Formulation: 50 µg of protein A-affinity purified antibody

Isotype: IgG

Applications: Dot blot, ELISA, ICC, IHC, MeDIP

Origin:

Stability: 365 days

Application|ELISA||Application|Immunocytochemistry||Application|Immunohistochemistry||Application|Immunoprecipitation||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Epigenetics, Transcription, & Translation|Writers|DNA/RNA Methylation

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