Antigen: oligomeric form of Aβ42 • Host: mouse • Isotype: IgG2b • Cross Reactivity: (+) human Aβ; unaggregated

Amyloid-β Monoclonal Antibody (Clone 6C3, MOAB-2) – 200 µg

Brand:
Cayman
Storage:

Amyloid plaques composed primarily of the 42 amino acid form of amyloid-β peptide (Aβ42) are a hallmark of Alzheimer’s disease (AD). However, the roles of the various amyloid β peptide(s), especially Aβ42, related to the neurotoxicity characteristic of AD remains unclear. A major hindrance to evaluating the role of Aβ in AD pathology has been the availability of anti-Aβ antibodies to selectively detect Aβ versus amyloid precursor protein (APP), Aβ40 versus Aβ42, and specific conformations of the peptide, particularly oligomeric forms. MOAB-2 (mouse IgG2b) is a pan-specific antibody specific to Aβ (residues 1-4) that differentiates intracellular Aβ from APP. MOAB-2 does not detect APP in cell culture media/lysates or in brain homogenates from transgenic mice expressing 5 familial AD mutation (5xFAD mice). Intraneuronal Aβ was confirmed by co-localization of MOAB-2 immunoreactivity with C-terminal antibodies specific for Aβ40 and Aβ42, and with cathepsin-D, a lysosomal marker. Additionally, MOAB-2 demonstrates strong intraneuronal and extra-cellular immunoreactivity in 5xFAD and 3xTg mouse brain tissues.{20683}  

 

Available on backorder

Add to quotes
SKU: 11610 - 200 µg Category:

Description

Antigen: oligomeric form of Aβ42 • Host: mouse • Isotype: IgG2b • Cross Reactivity: (+) human Aβ; unaggregated, oligomeric and fibrillar forms of synthetic Aβ42, and unaggregated Aβ40; (−) human APP • Application(s): WB, ELISA, ICC, and IP

Synonyms: Aβ

Immunogen: Oligomeric form of amyloid-β peptide (Aβ42)

Formulation: 200 µg of protein G-purified antibody

Isotype: IgG2b

Applications: ELISA, ICC, IP, and WB

Origin:

Stability: 365 days

Application|Immunohistochemistry||Application|Immunoprecipitation||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

Related products