Immunogen: Peptide corresponding to human ACC1 (phospho-Ser79) • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) ACC1 (phospho-Ser79); (-) ACC1 without phosphorylation at Ser79 • Applications: IHC

Acetyl-CoA Carboxylase 1 (Phospho-Ser79) Rabbit Monoclonal Antibody – 100 µl

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Cayman
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Acetyl-CoA carboxylase 1 (ACC1) is a biotin-dependent enzyme that catalyzes the conversion of acetyl CoA (Item No. 16160) to malonyl CoA (Item No. 16455), a building block in the biosynthesis of long-chain fatty acids.{60043,60044,60045} It is found at high levels in the liver and adipose tissue and is localized to the cytosol.{60045} Expression of ACC1 is increased by sterol regulatory element binding protein-1a (SREBP-1a) and SREBP-1c, which are induced by insulin, as well as the lipid precursors inositol and choline (Item No. 31178).{60043} ACC1 activity is increased by citrate and inhibited by binding to long-chain acyl-CoAs or by phosphorylation by a number of kinases, including AMPK and TAK1.{60043,60045,60046} Phosphorylation of ACC1 at serine 79 by AMPK inhibits the catalytic activities of ACC1, preventing the generation of malonyl-CoA, whereas dephosphorylation by protein phosphatase 4 promotes hepatic lipogenesis.{59583,59584} Knock-in mice with an alanine in place of serine at position 79 to prevent phosphorylation at this residue of Acc1 have increased de novo lipogenesis, reduced β-oxidation, and increased insulin resistance and glucose intolerance.{59583} Cayman’s Acetyl-CoA Carboxylase 1 (Phospho-Ser79) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.  

 

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SKU: 32220 - 100 µl Category:

Description

Immunogen: Peptide corresponding to human ACC1 (phospho-Ser79) • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) ACC1 (phospho-Ser79); (-) ACC1 without phosphorylation at Ser79 • Applications: IHC, WB

Synonyms: ACCα (Phospho-Ser79)|pACC1-Ser79|pSer79 ACC1

Immunogen: Peptide corresponding to human ACC1 (phospho-Ser79)

Formulation: 100 µl protein A-purified monoclonal antibody

Isotype: IgG

Applications: IHC, WB

Origin:

Stability: 365 days

Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Endocrinology & Metabolism|Nutrient Sensing||Research Area|Lipid Biochemistry|Acyl-CoAs||Research Area|Lipid Biochemistry|Fatty Acids|Degradation||Research Area|Lipid Biochemistry|Fatty Acids|Synthesis

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