Cayman
Showing 42601–42750 of 45550 results
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Phosphorylation of eIF2α by several kinases in response to cellular stress, including accumulation of unfolded proteins in the ER, results in a decrease in overall protein synthesis but upregulation of a small number of key regulatory proteins. trans-ISRIB (Integrated Stress Response Inhibitor) is a symmetric bis-glycolamide that inhibits the eIF2α phosphorylation-mediated unfolded protein response following induction of ER stress (IC50 = 5 nM in a cell-reporter assay).{27980} Although the mechanism of action is not established, it does not directly inhibit phosphorylation of eIF2α by upstream kinases. trans-ISRIB is able to pass through the blood-brain barrier and significantly enhances learning and memory in mice and rats.{27980}
Brand:CaymanSKU:-
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a dinucleotide second messenger that triggers the release of calcium from lysosomes and related cellular compartments.{28523} trans-Ned-19 is a structural analog of NAADP that blocks NAADP-dependent calcium release (IC50 = 6 nM) as well as NAADP binding to sea urchin egg homogenate (IC50 = 0.4 nM).{28527} The trans form of Ned-19 is significantly more potent than the cis isomer in both assays.{28527} Ned-19 does not affect either IP3-mediated calcium release or cyclic ADP-ribose-mediated calcium release.{28527} It directly binds NAADP receptors on lysosomes in mouse pancreatic beta cells and competitively antagonizes activation by NAADP.{28527,28526} It inhibits glucose-induced calcium oscillations in pancreatic islets and insulin-induced calcium increases in 3T3-L1 adipocytes.{28527,28525} Ned-19 also blocks calcium signaling induced by endothelin-1 or norepinephrine in renal afferent arterioles.{28424} Ned-19 dose-dependently reduces infection of host cells by Ebola virus.{28524}
Brand:CaymanSKU:-Available on backorder
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a dinucleotide second messenger that triggers the release of calcium from lysosomes and related cellular compartments.{28523} trans-Ned-19 is a structural analog of NAADP that blocks NAADP-dependent calcium release (IC50 = 6 nM) as well as NAADP binding to sea urchin egg homogenate (IC50 = 0.4 nM).{28527} The trans form of Ned-19 is significantly more potent than the cis isomer in both assays.{28527} Ned-19 does not affect either IP3-mediated calcium release or cyclic ADP-ribose-mediated calcium release.{28527} It directly binds NAADP receptors on lysosomes in mouse pancreatic beta cells and competitively antagonizes activation by NAADP.{28527,28526} It inhibits glucose-induced calcium oscillations in pancreatic islets and insulin-induced calcium increases in 3T3-L1 adipocytes.{28527,28525} Ned-19 also blocks calcium signaling induced by endothelin-1 or norepinephrine in renal afferent arterioles.{28424} Ned-19 dose-dependently reduces infection of host cells by Ebola virus.{28524}
Brand:CaymanSKU:-Available on backorder
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a dinucleotide second messenger that triggers the release of calcium from lysosomes and related cellular compartments.{28523} trans-Ned-19 is a structural analog of NAADP that blocks NAADP-dependent calcium release (IC50 = 6 nM) as well as NAADP binding to sea urchin egg homogenate (IC50 = 0.4 nM).{28527} The trans form of Ned-19 is significantly more potent than the cis isomer in both assays.{28527} Ned-19 does not affect either IP3-mediated calcium release or cyclic ADP-ribose-mediated calcium release.{28527} It directly binds NAADP receptors on lysosomes in mouse pancreatic beta cells and competitively antagonizes activation by NAADP.{28527,28526} It inhibits glucose-induced calcium oscillations in pancreatic islets and insulin-induced calcium increases in 3T3-L1 adipocytes.{28527,28525} Ned-19 also blocks calcium signaling induced by endothelin-1 or norepinephrine in renal afferent arterioles.{28424} Ned-19 dose-dependently reduces infection of host cells by Ebola virus.{28524}
Brand:CaymanSKU:-Available on backorder
trans-Nerolidol is a sesquiterpene that has been found in various plants, including C. sativa, and has diverse biological activities, including antimicrobial, antioxidant, anticancer, and insecticidal properties.{42316,43576,39868,43577} In a disc assay, trans-nerolidol inhibits the growth of S. aureus, B. subtilis, E. coli, and S. cerevisiae with zones of inhibition measuring 10, 9, 10, and 4 mm, respectively.{43576} It reduces viability of CaCo-2 adenocarcinoma cells with an IC50 value of 28.7 mg/L and reduces production of reactive oxygen species (ROS).{39868} trans-Nerolidol is insecticidal against A. aegypti larvae with a 24-hour LC50 value of 9 mg/L.{43577}
Brand:CaymanSKU:25778 - 100 mgAvailable on backorder
trans-Nerolidol is a sesquiterpene that has been found in various plants, including C. sativa, and has diverse biological activities, including antimicrobial, antioxidant, anticancer, and insecticidal properties.{42316,43576,39868,43577} In a disc assay, trans-nerolidol inhibits the growth of S. aureus, B. subtilis, E. coli, and S. cerevisiae with zones of inhibition measuring 10, 9, 10, and 4 mm, respectively.{43576} It reduces viability of CaCo-2 adenocarcinoma cells with an IC50 value of 28.7 mg/L and reduces production of reactive oxygen species (ROS).{39868} trans-Nerolidol is insecticidal against A. aegypti larvae with a 24-hour LC50 value of 9 mg/L.{43577}
Brand:CaymanSKU:25778 - 50 mgAvailable on backorder
trans-Petroselinic acid is the trans isomer of petroselinic acid (Item no. 20024) and an isomer of oleic acid (Item No. 90260) that has been found in cow, goat, and ewe milk fat as well as human breast milk.{41999,45000} In HepG2 cells, trans-petroselinic acid (100 μM) increases cellular content of triacylglycerols and cholesterol esters and upregulates transcription of genes involved in fatty acid synthesis, including SREBP-1c, ACACA, FASN, and SCD1, and cholesterol synthesis, including HMGCR, HMGCS1, FDFT1, and SREBP-2.{45001}
Brand:CaymanSKU:20026 -Available on backorder
trans-Petroselinic acid is the trans isomer of petroselinic acid (Item no. 20024) and an isomer of oleic acid (Item No. 90260) that has been found in cow, goat, and ewe milk fat as well as human breast milk.{41999,45000} In HepG2 cells, trans-petroselinic acid (100 μM) increases cellular content of triacylglycerols and cholesterol esters and upregulates transcription of genes involved in fatty acid synthesis, including SREBP-1c, ACACA, FASN, and SCD1, and cholesterol synthesis, including HMGCR, HMGCS1, FDFT1, and SREBP-2.{45001}
Brand:CaymanSKU:20026 -Available on backorder
trans-Petroselinic acid is the trans isomer of petroselinic acid (Item no. 20024) and an isomer of oleic acid (Item No. 90260) that has been found in cow, goat, and ewe milk fat as well as human breast milk.{41999,45000} In HepG2 cells, trans-petroselinic acid (100 μM) increases cellular content of triacylglycerols and cholesterol esters and upregulates transcription of genes involved in fatty acid synthesis, including SREBP-1c, ACACA, FASN, and SCD1, and cholesterol synthesis, including HMGCR, HMGCS1, FDFT1, and SREBP-2.{45001}
Brand:CaymanSKU:20026 -Available on backorder
trans-Petroselinic acid is the trans isomer of petroselinic acid (Item no. 20024) and an isomer of oleic acid (Item No. 90260) that has been found in cow, goat, and ewe milk fat as well as human breast milk.{41999,45000} In HepG2 cells, trans-petroselinic acid (100 μM) increases cellular content of triacylglycerols and cholesterol esters and upregulates transcription of genes involved in fatty acid synthesis, including SREBP-1c, ACACA, FASN, and SCD1, and cholesterol synthesis, including HMGCR, HMGCS1, FDFT1, and SREBP-2.{45001}
Brand:CaymanSKU:20026 -Available on backorder
trans-Resveratrol is a polyphenol that has been found in grapes and has diverse biological activities.{3491,43362} It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 μM, respectively) but not COX-2 (EC50s = >100 μM and 85 μM, respectively).{3491} trans-Resveratrol (200 μM) also activates sirtuin 1 (SIRT1), as well as inhibits a variety of targets including ERK1, JNK1, Src, PKCα, aromatase/CYP19, and DNA polymerases α and δ (IC50s = 37, 50, 20, in vitro.{13296,43362} It inhibits free radical formation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in HL-60 cells and reduces the tumor incidence and number of tumors in a two-stage mouse model of skin cancer induced by TPA and 7,12-dimethyl-benz[a]anthracene (DMBA). trans-Resveratrol (3 and 8 mg/kg) inhibits carrageenan-induced paw edema in mice. Intravaginal administration of trans-resveratrol (12.5% v/v) inhibits herpes simplex virus 1 (HSV-1) and HSV-2 replication and delays the development of extravaginal disease in mouse models of vaginal HSV infection.{60119} It also prolongs lifespan in model organisms including C. elegans, D. melanogaster, and mice.{43362}
Brand:CaymanSKU:70675 - 100 mgAvailable on backorder
trans-Resveratrol is a polyphenol that has been found in grapes and has diverse biological activities.{3491,43362} It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 μM, respectively) but not COX-2 (EC50s = >100 μM and 85 μM, respectively).{3491} trans-Resveratrol (200 μM) also activates sirtuin 1 (SIRT1), as well as inhibits a variety of targets including ERK1, JNK1, Src, PKCα, aromatase/CYP19, and DNA polymerases α and δ (IC50s = 37, 50, 20, in vitro.{13296,43362} It inhibits free radical formation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in HL-60 cells and reduces the tumor incidence and number of tumors in a two-stage mouse model of skin cancer induced by TPA and 7,12-dimethyl-benz[a]anthracene (DMBA). trans-Resveratrol (3 and 8 mg/kg) inhibits carrageenan-induced paw edema in mice. Intravaginal administration of trans-resveratrol (12.5% v/v) inhibits herpes simplex virus 1 (HSV-1) and HSV-2 replication and delays the development of extravaginal disease in mouse models of vaginal HSV infection.{60119} It also prolongs lifespan in model organisms including C. elegans, D. melanogaster, and mice.{43362}
Brand:CaymanSKU:70675 - 250 mgAvailable on backorder
trans-Resveratrol is a polyphenol that has been found in grapes and has diverse biological activities.{3491,43362} It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 μM, respectively) but not COX-2 (EC50s = >100 μM and 85 μM, respectively).{3491} trans-Resveratrol (200 μM) also activates sirtuin 1 (SIRT1), as well as inhibits a variety of targets including ERK1, JNK1, Src, PKCα, aromatase/CYP19, and DNA polymerases α and δ (IC50s = 37, 50, 20, in vitro.{13296,43362} It inhibits free radical formation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in HL-60 cells and reduces the tumor incidence and number of tumors in a two-stage mouse model of skin cancer induced by TPA and 7,12-dimethyl-benz[a]anthracene (DMBA). trans-Resveratrol (3 and 8 mg/kg) inhibits carrageenan-induced paw edema in mice. Intravaginal administration of trans-resveratrol (12.5% v/v) inhibits herpes simplex virus 1 (HSV-1) and HSV-2 replication and delays the development of extravaginal disease in mouse models of vaginal HSV infection.{60119} It also prolongs lifespan in model organisms including C. elegans, D. melanogaster, and mice.{43362}
Brand:CaymanSKU:70675 - 50 mgAvailable on backorder
trans-Resveratrol is a polyphenol that has been found in grapes and has diverse biological activities.{3491,43362} It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 μM, respectively) but not COX-2 (EC50s = >100 μM and 85 μM, respectively).{3491} trans-Resveratrol (200 μM) also activates sirtuin 1 (SIRT1), as well as inhibits a variety of targets including ERK1, JNK1, Src, PKCα, aromatase/CYP19, and DNA polymerases α and δ (IC50s = 37, 50, 20, in vitro.{13296,43362} It inhibits free radical formation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in HL-60 cells and reduces the tumor incidence and number of tumors in a two-stage mouse model of skin cancer induced by TPA and 7,12-dimethyl-benz[a]anthracene (DMBA). trans-Resveratrol (3 and 8 mg/kg) inhibits carrageenan-induced paw edema in mice. Intravaginal administration of trans-resveratrol (12.5% v/v) inhibits herpes simplex virus 1 (HSV-1) and HSV-2 replication and delays the development of extravaginal disease in mouse models of vaginal HSV infection.{60119} It also prolongs lifespan in model organisms including C. elegans, D. melanogaster, and mice.{43362}
Brand:CaymanSKU:70675 - 500 mgAvailable on backorder
Resveratrol is a potent phenolic antioxidant found in grapes and red wine that also has antiproliferative and anti-inflammatory activity.{9146} In humans, resveratrol is almost completely conjugated to its glucuronide and sulfate metabolites.{12177} trans-Resveratrol-3-O-β-D-glucuronide is a regioisomeric resveratrol metabolite that may be used as a reference standard for accurate determination of the metabolic profile of resveratrol.
Brand:CaymanSKU:- Resveratrol is a potent phenolic antioxidant found in grapes and red wine that also has antiproliferative and anti-inflammatory activity.{9146} In humans, resveratrol is almost completely conjugated to its glucuronide and sulfate metabolites.{12177} trans-Resveratrol-3-O-β-D-glucuronide is a regioisomeric resveratrol metabolite that may be used as a reference standard for accurate determination of the metabolic profile of resveratrol.
Brand:CaymanSKU:- Resveratrol is a potent phenolic antioxidant found in grapes and red wine that also has antiproliferative and anti-inflammatory activity.{9146} In humans, resveratrol is almost completely conjugated to its glucuronide and sulfate metabolites.{12177} trans-Resveratrol-3-O-β-D-glucuronide is a regioisomeric resveratrol metabolite that may be used as a reference standard for accurate determination of the metabolic profile of resveratrol.
Brand:CaymanSKU:-
trans-Resveratrol-4′-O-D-glucuronide is a phase II metabolite of the antioxidant trans-resveratrol (Item No. 70675).{47175} trans-Resveratrol-4′-O-D-glucuronide is formed via glucuronidation of trans-resveratrol by the UDP-glucuronosyltransferase (UGT) isoform UGT1A9.
Brand:CaymanSKU:- trans-Resveratrol-4′-O-D-glucuronide is a phase II metabolite of the antioxidant trans-resveratrol (Item No. 70675).{47175} trans-Resveratrol-4′-O-D-glucuronide is formed via glucuronidation of trans-resveratrol by the UDP-glucuronosyltransferase (UGT) isoform UGT1A9.
Brand:CaymanSKU:- trans-Resveratrol-4′-O-D-glucuronide is a phase II metabolite of the antioxidant trans-resveratrol (Item No. 70675).{47175} trans-Resveratrol-4′-O-D-glucuronide is formed via glucuronidation of trans-resveratrol by the UDP-glucuronosyltransferase (UGT) isoform UGT1A9.
Brand:CaymanSKU:-
trans-Resveratrol-d4 is intended for use as an internal standard for the quantification of trans-resveratrol (Item No. 70675) by GC- or LC-MS. trans-Resveratrol is a polyphenolic phytoalexin found in a variety of plants, including grapes, that has anti-inflammatory, antioxidant, and anticancer activities.{3491,43362} It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 μM, respectively), but not COX-2 (EC50s = >100 μM and 85 μM, respectively).{3491} trans-Resveratrol (3 and 8 mg/kg) inhibits carrageenan-induced paw edema in mice. It inhibits free radical formation in HL-60 human promyelocytic leukemia cells induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014; EC50 = 27 μM). trans-Resveratrol (1-25 μmol) reduces both the incidence and number of tumors in a two-stage mouse model of skin cancer induced by TPA and 7,12-dimethyl-benz[a]anthracene (DMBA). trans-Resveratrol (200 μM) also activates sirtuin 1 (SIRT1) by 8-fold in vitro and inhibits a variety of targets including ERK1, JNK1, Src, PKCα, aromatase/CYP19, and DNA polymerases α and δ (IC50s = 37, 50, 20, in vitro and/or ex vivo.{13296,43362} It prolongs lifespan in model organisms including C. elegans, D. melanogaster, and mice.{43362}
Brand:CaymanSKU:- trans-Resveratrol-d4 is intended for use as an internal standard for the quantification of trans-resveratrol (Item No. 70675) by GC- or LC-MS. trans-Resveratrol is a polyphenolic phytoalexin found in a variety of plants, including grapes, that has anti-inflammatory, antioxidant, and anticancer activities.{3491,43362} It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 μM, respectively), but not COX-2 (EC50s = >100 μM and 85 μM, respectively).{3491} trans-Resveratrol (3 and 8 mg/kg) inhibits carrageenan-induced paw edema in mice. It inhibits free radical formation in HL-60 human promyelocytic leukemia cells induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014; EC50 = 27 μM). trans-Resveratrol (1-25 μmol) reduces both the incidence and number of tumors in a two-stage mouse model of skin cancer induced by TPA and 7,12-dimethyl-benz[a]anthracene (DMBA). trans-Resveratrol (200 μM) also activates sirtuin 1 (SIRT1) by 8-fold in vitro and inhibits a variety of targets including ERK1, JNK1, Src, PKCα, aromatase/CYP19, and DNA polymerases α and δ (IC50s = 37, 50, 20, in vitro and/or ex vivo.{13296,43362} It prolongs lifespan in model organisms including C. elegans, D. melanogaster, and mice.{43362}
Brand:CaymanSKU:- trans-Resveratrol-d4 is intended for use as an internal standard for the quantification of trans-resveratrol (Item No. 70675) by GC- or LC-MS. trans-Resveratrol is a polyphenolic phytoalexin found in a variety of plants, including grapes, that has anti-inflammatory, antioxidant, and anticancer activities.{3491,43362} It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 μM, respectively), but not COX-2 (EC50s = >100 μM and 85 μM, respectively).{3491} trans-Resveratrol (3 and 8 mg/kg) inhibits carrageenan-induced paw edema in mice. It inhibits free radical formation in HL-60 human promyelocytic leukemia cells induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014; EC50 = 27 μM). trans-Resveratrol (1-25 μmol) reduces both the incidence and number of tumors in a two-stage mouse model of skin cancer induced by TPA and 7,12-dimethyl-benz[a]anthracene (DMBA). trans-Resveratrol (200 μM) also activates sirtuin 1 (SIRT1) by 8-fold in vitro and inhibits a variety of targets including ERK1, JNK1, Src, PKCα, aromatase/CYP19, and DNA polymerases α and δ (IC50s = 37, 50, 20, in vitro and/or ex vivo.{13296,43362} It prolongs lifespan in model organisms including C. elegans, D. melanogaster, and mice.{43362}
Brand:CaymanSKU:- trans-Resveratrol-d4 is intended for use as an internal standard for the quantification of trans-resveratrol (Item No. 70675) by GC- or LC-MS. trans-Resveratrol is a polyphenolic phytoalexin found in a variety of plants, including grapes, that has anti-inflammatory, antioxidant, and anticancer activities.{3491,43362} It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 μM, respectively), but not COX-2 (EC50s = >100 μM and 85 μM, respectively).{3491} trans-Resveratrol (3 and 8 mg/kg) inhibits carrageenan-induced paw edema in mice. It inhibits free radical formation in HL-60 human promyelocytic leukemia cells induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014; EC50 = 27 μM). trans-Resveratrol (1-25 μmol) reduces both the incidence and number of tumors in a two-stage mouse model of skin cancer induced by TPA and 7,12-dimethyl-benz[a]anthracene (DMBA). trans-Resveratrol (200 μM) also activates sirtuin 1 (SIRT1) by 8-fold in vitro and inhibits a variety of targets including ERK1, JNK1, Src, PKCα, aromatase/CYP19, and DNA polymerases α and δ (IC50s = 37, 50, 20, in vitro and/or ex vivo.{13296,43362} It prolongs lifespan in model organisms including C. elegans, D. melanogaster, and mice.{43362}
Brand:CaymanSKU:-
Phenolic compounds, particularly flavonoids, from plant sources have long been observed to have antioxidant activity with potential benefits for human health.{7442,6817,8914} Resveratrol is a potent phenolic antioxidant found in grapes and red wine that also has antiproliferative and anti-inflammatory activity.{9146} When the three phenolic hydroxyl groups of resveratrol are converted to methyl ethers, the inhibition of cell growth and pro-apoptotic activities of resveratrol are enhanced.{10510}
Brand:CaymanSKU:10188 - 100 mgAvailable on backorder
Phenolic compounds, particularly flavonoids, from plant sources have long been observed to have antioxidant activity with potential benefits for human health.{7442,6817,8914} Resveratrol is a potent phenolic antioxidant found in grapes and red wine that also has antiproliferative and anti-inflammatory activity.{9146} When the three phenolic hydroxyl groups of resveratrol are converted to methyl ethers, the inhibition of cell growth and pro-apoptotic activities of resveratrol are enhanced.{10510}
Brand:CaymanSKU:10188 - 250 mgAvailable on backorder
Phenolic compounds, particularly flavonoids, from plant sources have long been observed to have antioxidant activity with potential benefits for human health.{7442,6817,8914} Resveratrol is a potent phenolic antioxidant found in grapes and red wine that also has antiproliferative and anti-inflammatory activity.{9146} When the three phenolic hydroxyl groups of resveratrol are converted to methyl ethers, the inhibition of cell growth and pro-apoptotic activities of resveratrol are enhanced.{10510}
Brand:CaymanSKU:10188 - 50 mgAvailable on backorder
Phenolic compounds, particularly flavonoids, from plant sources have long been observed to have antioxidant activity with potential benefits for human health.{7442,6817,8914} Resveratrol is a potent phenolic antioxidant found in grapes and red wine that also has antiproliferative and anti-inflammatory activity.{9146} When the three phenolic hydroxyl groups of resveratrol are converted to methyl ethers, the inhibition of cell growth and pro-apoptotic activities of resveratrol are enhanced.{10510}
Brand:CaymanSKU:10188 - 500 mgAvailable on backorder
trans-trismethoxy Resveratrol-d4 contains four deuterium atoms at the 2, 3, 5, and 6 positions. It is intended for use as an internal standard for the quantification of trans-trismethoxy resveratrol by GC- or LC-mass spectrometry. Phenolic compounds, particularly flavonoids, from plant sources have long been observed to have antioxidant activity with potential benefits for human health.{7442,6817,8914} Resveratrol is a potent phenolic antioxidant found in grapes and red wine that also has antiproliferative and anti-inflammatory activity.{9146} When the three phenolic hydroxyl groups of resveratrol are converted to methyl ethers, the inhibition of cell growth and pro-apoptotic activities of resveratrol are enhanced.{10510}
Brand:CaymanSKU:- trans-trismethoxy Resveratrol-d4 contains four deuterium atoms at the 2, 3, 5, and 6 positions. It is intended for use as an internal standard for the quantification of trans-trismethoxy resveratrol by GC- or LC-mass spectrometry. Phenolic compounds, particularly flavonoids, from plant sources have long been observed to have antioxidant activity with potential benefits for human health.{7442,6817,8914} Resveratrol is a potent phenolic antioxidant found in grapes and red wine that also has antiproliferative and anti-inflammatory activity.{9146} When the three phenolic hydroxyl groups of resveratrol are converted to methyl ethers, the inhibition of cell growth and pro-apoptotic activities of resveratrol are enhanced.{10510}
Brand:CaymanSKU:- trans-trismethoxy Resveratrol-d4 contains four deuterium atoms at the 2, 3, 5, and 6 positions. It is intended for use as an internal standard for the quantification of trans-trismethoxy resveratrol by GC- or LC-mass spectrometry. Phenolic compounds, particularly flavonoids, from plant sources have long been observed to have antioxidant activity with potential benefits for human health.{7442,6817,8914} Resveratrol is a potent phenolic antioxidant found in grapes and red wine that also has antiproliferative and anti-inflammatory activity.{9146} When the three phenolic hydroxyl groups of resveratrol are converted to methyl ethers, the inhibition of cell growth and pro-apoptotic activities of resveratrol are enhanced.{10510}
Brand:CaymanSKU:- trans-trismethoxy Resveratrol-d4 contains four deuterium atoms at the 2, 3, 5, and 6 positions. It is intended for use as an internal standard for the quantification of trans-trismethoxy resveratrol by GC- or LC-mass spectrometry. Phenolic compounds, particularly flavonoids, from plant sources have long been observed to have antioxidant activity with potential benefits for human health.{7442,6817,8914} Resveratrol is a potent phenolic antioxidant found in grapes and red wine that also has antiproliferative and anti-inflammatory activity.{9146} When the three phenolic hydroxyl groups of resveratrol are converted to methyl ethers, the inhibition of cell growth and pro-apoptotic activities of resveratrol are enhanced.{10510}
Brand:CaymanSKU:-
trans-Urocanic acid is a major epidermal chromophore for the immunosuppressive effects of UV radiation that is produced in mammalian stratum corneum by the action of histidine ammonialyase on L-histidine.{26632} It contributes to the acidification of the surface of the stratum corneum, and its function has been proposed as that of an endogenous sunscreen, endowing a low-level of protection (SPF ~ 1.5) against UV-induced DNA damage and excessive keratinocyte apoptosis.{26632} Upon UVB exposure, trans-urocanic acid is converted to the cis isomer, which is known to activate regulatory T cells.{26631}
Brand:CaymanSKU:- trans-Urocanic acid is a major epidermal chromophore for the immunosuppressive effects of UV radiation that is produced in mammalian stratum corneum by the action of histidine ammonialyase on L-histidine.{26632} It contributes to the acidification of the surface of the stratum corneum, and its function has been proposed as that of an endogenous sunscreen, endowing a low-level of protection (SPF ~ 1.5) against UV-induced DNA damage and excessive keratinocyte apoptosis.{26632} Upon UVB exposure, trans-urocanic acid is converted to the cis isomer, which is known to activate regulatory T cells.{26631}
Brand:CaymanSKU:-
trans-Vaccenic acid is an ω-7 fatty acid that has been found in bovine milk fats.{25285} Dietary administration of trans-vaccenic acid (1% w/w) reduces total body fat, mesenteric fat, and adipocyte size, increases inguinal fat mass, and decreases intestinal and hepatic triglyceride secretion in a rat model of obesity with features of metabolic syndrome.{52757} It decreases hepatocellular ballooning and steatosis, markers of non-alcoholic fatty liver disease (NAFLD), in the same model. Dietary administration of a butter enriched with trans-vaccenic acid decreases serum cholesterol levels and the formation of aortic atherosclerotic lesions in Ldlr-/- mice.{25287}
Brand:CaymanSKU:- trans-Vaccenic acid is an ω-7 fatty acid that has been found in bovine milk fats.{25285} Dietary administration of trans-vaccenic acid (1% w/w) reduces total body fat, mesenteric fat, and adipocyte size, increases inguinal fat mass, and decreases intestinal and hepatic triglyceride secretion in a rat model of obesity with features of metabolic syndrome.{52757} It decreases hepatocellular ballooning and steatosis, markers of non-alcoholic fatty liver disease (NAFLD), in the same model. Dietary administration of a butter enriched with trans-vaccenic acid decreases serum cholesterol levels and the formation of aortic atherosclerotic lesions in Ldlr-/- mice.{25287}
Brand:CaymanSKU:- trans-Vaccenic acid is an ω-7 fatty acid that has been found in bovine milk fats.{25285} Dietary administration of trans-vaccenic acid (1% w/w) reduces total body fat, mesenteric fat, and adipocyte size, increases inguinal fat mass, and decreases intestinal and hepatic triglyceride secretion in a rat model of obesity with features of metabolic syndrome.{52757} It decreases hepatocellular ballooning and steatosis, markers of non-alcoholic fatty liver disease (NAFLD), in the same model. Dietary administration of a butter enriched with trans-vaccenic acid decreases serum cholesterol levels and the formation of aortic atherosclerotic lesions in Ldlr-/- mice.{25287}
Brand:CaymanSKU:- trans-Vaccenic acid is an ω-7 fatty acid that has been found in bovine milk fats.{25285} Dietary administration of trans-vaccenic acid (1% w/w) reduces total body fat, mesenteric fat, and adipocyte size, increases inguinal fat mass, and decreases intestinal and hepatic triglyceride secretion in a rat model of obesity with features of metabolic syndrome.{52757} It decreases hepatocellular ballooning and steatosis, markers of non-alcoholic fatty liver disease (NAFLD), in the same model. Dietary administration of a butter enriched with trans-vaccenic acid decreases serum cholesterol levels and the formation of aortic atherosclerotic lesions in Ldlr-/- mice.{25287}
Brand:CaymanSKU:-
trans-Vaccenic acid methyl ester is an esterified form of trans-vaccenic acid (Item No. 15301). It has been used as a standard for the identification and quantification of fatty acids in Uruguayan Colonia cheese by GC-MS.{45197}
Brand:CaymanSKU:26731 - 100 mgAvailable on backorder
trans-Vaccenic acid methyl ester is an esterified form of trans-vaccenic acid (Item No. 15301). It has been used as a standard for the identification and quantification of fatty acids in Uruguayan Colonia cheese by GC-MS.{45197}
Brand:CaymanSKU:26731 - 25 mgAvailable on backorder
trans-Vaccenic acid methyl ester is an esterified form of trans-vaccenic acid (Item No. 15301). It has been used as a standard for the identification and quantification of fatty acids in Uruguayan Colonia cheese by GC-MS.{45197}
Brand:CaymanSKU:26731 - 250 mgAvailable on backorder
trans-Vaccenic acid methyl ester is an esterified form of trans-vaccenic acid (Item No. 15301). It has been used as a standard for the identification and quantification of fatty acids in Uruguayan Colonia cheese by GC-MS.{45197}
Brand:CaymanSKU:26731 - 50 mgAvailable on backorder
trans-Zeatin is a cytokinin plant growth regulator with antioxidant and neuroprotective activities.{48717,48718,17848,48719} It binds to the cytokinin receptor Arabidopsis histidine kinase 3 (AHK3) with a KD value of 1.3 nM.{17848} trans-Zeatin increases chlorophyll levels in etiolated Cucumus sativus cotyledons in a concentration-dependent manner.{48717} It increases callus growth and shoot formation in N. tabacum calluses when used at concentrations of 5 and 50 µM.{48718} trans-Zeatin (25-100 µM) reduces production of reactive oxygen species (ROS) induced by amyloid β (25-35) (Aβ25-35) in PC12 cells.{48719} It reduces scopolamine-induced spontaneous alternations in the Y-maze, indicating enhanced spatial memory, in mice when administered at doses of 1.5, 3, and 4.5 mg/kg per day.
Brand:CaymanSKU:- trans-Zeatin is a cytokinin plant growth regulator with antioxidant and neuroprotective activities.{48717,48718,17848,48719} It binds to the cytokinin receptor Arabidopsis histidine kinase 3 (AHK3) with a KD value of 1.3 nM.{17848} trans-Zeatin increases chlorophyll levels in etiolated Cucumus sativus cotyledons in a concentration-dependent manner.{48717} It increases callus growth and shoot formation in N. tabacum calluses when used at concentrations of 5 and 50 µM.{48718} trans-Zeatin (25-100 µM) reduces production of reactive oxygen species (ROS) induced by amyloid β (25-35) (Aβ25-35) in PC12 cells.{48719} It reduces scopolamine-induced spontaneous alternations in the Y-maze, indicating enhanced spatial memory, in mice when administered at doses of 1.5, 3, and 4.5 mg/kg per day.
Brand:CaymanSKU:- trans-Zeatin is a cytokinin plant growth regulator with antioxidant and neuroprotective activities.{48717,48718,17848,48719} It binds to the cytokinin receptor Arabidopsis histidine kinase 3 (AHK3) with a KD value of 1.3 nM.{17848} trans-Zeatin increases chlorophyll levels in etiolated Cucumus sativus cotyledons in a concentration-dependent manner.{48717} It increases callus growth and shoot formation in N. tabacum calluses when used at concentrations of 5 and 50 µM.{48718} trans-Zeatin (25-100 µM) reduces production of reactive oxygen species (ROS) induced by amyloid β (25-35) (Aβ25-35) in PC12 cells.{48719} It reduces scopolamine-induced spontaneous alternations in the Y-maze, indicating enhanced spatial memory, in mice when administered at doses of 1.5, 3, and 4.5 mg/kg per day.
Brand:CaymanSKU:- trans-Zeatin is a cytokinin plant growth regulator with antioxidant and neuroprotective activities.{48717,48718,17848,48719} It binds to the cytokinin receptor Arabidopsis histidine kinase 3 (AHK3) with a KD value of 1.3 nM.{17848} trans-Zeatin increases chlorophyll levels in etiolated Cucumus sativus cotyledons in a concentration-dependent manner.{48717} It increases callus growth and shoot formation in N. tabacum calluses when used at concentrations of 5 and 50 µM.{48718} trans-Zeatin (25-100 µM) reduces production of reactive oxygen species (ROS) induced by amyloid β (25-35) (Aβ25-35) in PC12 cells.{48719} It reduces scopolamine-induced spontaneous alternations in the Y-maze, indicating enhanced spatial memory, in mice when administered at doses of 1.5, 3, and 4.5 mg/kg per day.
Brand:CaymanSKU:-
trans-Zeatin riboside is a cytokinin that has been found in squash root xylem sap.{54277} It suppresses hypocotyl adventitious root formation in cucumber plants when used at concentrations ranging from 0.001 to 1 µM. trans-Zeatin riboside (10 µM) increases the activity of superoxide dismutase (SOD), ascorbate peroxidase (APX), catalase (CAT), and guaiacol peroxidase (POD) in the leaves, as well as improves turf quality and delays leaf wilting in a creeping bentgrass model of drought stress.{54276}
Brand:CaymanSKU:30747 - 100 mgAvailable on backorder
trans-Zeatin riboside is a cytokinin that has been found in squash root xylem sap.{54277} It suppresses hypocotyl adventitious root formation in cucumber plants when used at concentrations ranging from 0.001 to 1 µM. trans-Zeatin riboside (10 µM) increases the activity of superoxide dismutase (SOD), ascorbate peroxidase (APX), catalase (CAT), and guaiacol peroxidase (POD) in the leaves, as well as improves turf quality and delays leaf wilting in a creeping bentgrass model of drought stress.{54276}
Brand:CaymanSKU:30747 - 50 mgAvailable on backorder
trans-Zeatin riboside is a cytokinin that has been found in squash root xylem sap.{54277} It suppresses hypocotyl adventitious root formation in cucumber plants when used at concentrations ranging from 0.001 to 1 µM. trans-Zeatin riboside (10 µM) increases the activity of superoxide dismutase (SOD), ascorbate peroxidase (APX), catalase (CAT), and guaiacol peroxidase (POD) in the leaves, as well as improves turf quality and delays leaf wilting in a creeping bentgrass model of drought stress.{54276}
Brand:CaymanSKU:30747 - 500 mgAvailable on backorder
trans-β-Farnesene is a volatile sesquiterpene hydrocarbon that has been found in aphids and has alarm pheromone and kairomonal attractant activities.{61056,61057} It is produced by aphids in response to predator or parasite attack.{61056} trans-β-Farnesene (0.2 ng) induces dispersion of 50% of M. persicae aphids from a cluster. trans-β-Farnesene (>2 μg) also acts as a kairomone, attracting larvae and adults of A. bipunctata, a predator of aphids.{61057}
Brand:CaymanSKU:31502 - 1 gAvailable on backorder
trans-β-Farnesene is a volatile sesquiterpene hydrocarbon that has been found in aphids and has alarm pheromone and kairomonal attractant activities.{61056,61057} It is produced by aphids in response to predator or parasite attack.{61056} trans-β-Farnesene (0.2 ng) induces dispersion of 50% of M. persicae aphids from a cluster. trans-β-Farnesene (>2 μg) also acts as a kairomone, attracting larvae and adults of A. bipunctata, a predator of aphids.{61057}
Brand:CaymanSKU:31502 - 100 mgAvailable on backorder
trans-β-Farnesene is a volatile sesquiterpene hydrocarbon that has been found in aphids and has alarm pheromone and kairomonal attractant activities.{61056,61057} It is produced by aphids in response to predator or parasite attack.{61056} trans-β-Farnesene (0.2 ng) induces dispersion of 50% of M. persicae aphids from a cluster. trans-β-Farnesene (>2 μg) also acts as a kairomone, attracting larvae and adults of A. bipunctata, a predator of aphids.{61057}
Brand:CaymanSKU:31502 - 250 mgAvailable on backorder
trans-β-Farnesene is a volatile sesquiterpene hydrocarbon that has been found in aphids and has alarm pheromone and kairomonal attractant activities.{61056,61057} It is produced by aphids in response to predator or parasite attack.{61056} trans-β-Farnesene (0.2 ng) induces dispersion of 50% of M. persicae aphids from a cluster. trans-β-Farnesene (>2 μg) also acts as a kairomone, attracting larvae and adults of A. bipunctata, a predator of aphids.{61057}
Brand:CaymanSKU:31502 - 500 mgAvailable on backorder
trans-β-Ocimene is a monoterpene and isomer of β-ocimene (Item No. 23466) that has been found in a variety of plants, including Cannabis.{43357,42452,42455) It is a volatile compound involved in plant-plant signaling and plant defense against pests. Emission of trans-β-ocimene from L. japonicus plants is induced within 24 hours of spider mite (T. urticae) infestation.{42452} Conditioning of tomato plants using volatile organic compounds (VOCs) from transgenic tobacco plants overexpressing trans-β-ocimene synthase increases production of VOCs and reduces the number of aphids (M. euphorbiae) that settle on the plant and the number of nymphs produced by the aphids that settle, as well as increases the number of landings of the aphid parasitoid A. ervi compared with conditioning using wild-type tobacco VOCs.{42455}
Brand:CaymanSKU:29393 - 10 mgAvailable on backorder
trans-β-Ocimene is a monoterpene and isomer of β-ocimene (Item No. 23466) that has been found in a variety of plants, including Cannabis.{43357,42452,42455) It is a volatile compound involved in plant-plant signaling and plant defense against pests. Emission of trans-β-ocimene from L. japonicus plants is induced within 24 hours of spider mite (T. urticae) infestation.{42452} Conditioning of tomato plants using volatile organic compounds (VOCs) from transgenic tobacco plants overexpressing trans-β-ocimene synthase increases production of VOCs and reduces the number of aphids (M. euphorbiae) that settle on the plant and the number of nymphs produced by the aphids that settle, as well as increases the number of landings of the aphid parasitoid A. ervi compared with conditioning using wild-type tobacco VOCs.{42455}
Brand:CaymanSKU:29393 - 25 mgAvailable on backorder
trans-β-Ocimene is a monoterpene and isomer of β-ocimene (Item No. 23466) that has been found in a variety of plants, including Cannabis.{43357,42452,42455) It is a volatile compound involved in plant-plant signaling and plant defense against pests. Emission of trans-β-ocimene from L. japonicus plants is induced within 24 hours of spider mite (T. urticae) infestation.{42452} Conditioning of tomato plants using volatile organic compounds (VOCs) from transgenic tobacco plants overexpressing trans-β-ocimene synthase increases production of VOCs and reduces the number of aphids (M. euphorbiae) that settle on the plant and the number of nymphs produced by the aphids that settle, as well as increases the number of landings of the aphid parasitoid A. ervi compared with conditioning using wild-type tobacco VOCs.{42455}
Brand:CaymanSKU:29393 - 5 mgAvailable on backorder
Both prokaryotes and eukaryotes depend on small signalling molecules for cell-cell communication. trans-Δ2-11-methyl-Dodecenoic acid is the conformational isomer of cis-Δ2-11-methyl-dodecenoic acid, a diffusible signal factor (DSF) in extracellular microbial and fungal communication systems.{13766} In a DSF bioassay, the minimum concentration of cis-Δ2-11-methyl-dodecenoic acid required for induction of a DSF biosensor was about 0.5 µM, which is 200-fold lower than that of trans-Δ2-11-methyl-dodecenoic acid and 20,000-fold lower than that of the corresponding saturated fatty acid (11-methyl-dodecanoic acid).
Brand:CaymanSKU:10008321 - 1 mgAvailable on backorder
Both prokaryotes and eukaryotes depend on small signalling molecules for cell-cell communication. trans-Δ2-11-methyl-Dodecenoic acid is the conformational isomer of cis-Δ2-11-methyl-dodecenoic acid, a diffusible signal factor (DSF) in extracellular microbial and fungal communication systems.{13766} In a DSF bioassay, the minimum concentration of cis-Δ2-11-methyl-dodecenoic acid required for induction of a DSF biosensor was about 0.5 µM, which is 200-fold lower than that of trans-Δ2-11-methyl-dodecenoic acid and 20,000-fold lower than that of the corresponding saturated fatty acid (11-methyl-dodecanoic acid).
Brand:CaymanSKU:10008321 - 10 mgAvailable on backorder
Both prokaryotes and eukaryotes depend on small signalling molecules for cell-cell communication. trans-Δ2-11-methyl-Dodecenoic acid is the conformational isomer of cis-Δ2-11-methyl-dodecenoic acid, a diffusible signal factor (DSF) in extracellular microbial and fungal communication systems.{13766} In a DSF bioassay, the minimum concentration of cis-Δ2-11-methyl-dodecenoic acid required for induction of a DSF biosensor was about 0.5 µM, which is 200-fold lower than that of trans-Δ2-11-methyl-dodecenoic acid and 20,000-fold lower than that of the corresponding saturated fatty acid (11-methyl-dodecanoic acid).
Brand:CaymanSKU:10008321 - 5 mgAvailable on backorder
Both prokaryotes and eukaryotes depend on small signalling molecules for cell-cell communication. trans-Δ2-11-methyl-Dodecenoic acid is the conformational isomer of cis-Δ2-11-methyl-dodecenoic acid, a diffusible signal factor (DSF) in extracellular microbial and fungal communication systems.{13766} In a DSF bioassay, the minimum concentration of cis-Δ2-11-methyl-dodecenoic acid required for induction of a DSF biosensor was about 0.5 µM, which is 200-fold lower than that of trans-Δ2-11-methyl-dodecenoic acid and 20,000-fold lower than that of the corresponding saturated fatty acid (11-methyl-dodecanoic acid).
Brand:CaymanSKU:10008321 - 50 mgAvailable on backorder
trans-ε-Viniferin is a stilbene polyphenol and dimer of trans-resveratrol (Item No. 70675) that has been found in various red wines and has diverse biological activities.{47517,47518,47519,47520,47521} It induces disaggregation of aggregated amyloid-β (1-42) (Aβ42; Item No. 20574) fibrils in a cell-free assay and decreases Aβ42- and IL-1β-induced release of TNF-α and IL-6 in primary mouse neuron and astrocyte cocultures.{47518} trans-ε-Viniferin reduces cytotoxicity induced by truncated huntingtin (Htt) in PC12 cells (EC50 = 30 nM).{47519} It also reduces production of reactive oxygen species (ROS), mitochondrial dysfunction, and PGC-1α depletion and increases protein levels and deacetylase activity of sirtuin 3 (SIRT3) in cells expressing mutant Htt. trans-ε-Viniferin inhibits calcium-activated chloride channel currents in HT-29 cells (IC50 = ~1 μM).{47520} In vivo, trans-ε-viniferin (2 μg per animal) reduces rotavirus-induced secretory diarrhea in mice without affecting the rotaviral infection. Dietary administration of trans-ε-viniferin reduces hepatic triglyceride accumulation and body weight increases in a mouse model of diet-induced obesity.{47521}
Brand:CaymanSKU:25737 - 1 mgAvailable on backorder
trans-ε-Viniferin is a stilbene polyphenol and dimer of trans-resveratrol (Item No. 70675) that has been found in various red wines and has diverse biological activities.{47517,47518,47519,47520,47521} It induces disaggregation of aggregated amyloid-β (1-42) (Aβ42; Item No. 20574) fibrils in a cell-free assay and decreases Aβ42- and IL-1β-induced release of TNF-α and IL-6 in primary mouse neuron and astrocyte cocultures.{47518} trans-ε-Viniferin reduces cytotoxicity induced by truncated huntingtin (Htt) in PC12 cells (EC50 = 30 nM).{47519} It also reduces production of reactive oxygen species (ROS), mitochondrial dysfunction, and PGC-1α depletion and increases protein levels and deacetylase activity of sirtuin 3 (SIRT3) in cells expressing mutant Htt. trans-ε-Viniferin inhibits calcium-activated chloride channel currents in HT-29 cells (IC50 = ~1 μM).{47520} In vivo, trans-ε-viniferin (2 μg per animal) reduces rotavirus-induced secretory diarrhea in mice without affecting the rotaviral infection. Dietary administration of trans-ε-viniferin reduces hepatic triglyceride accumulation and body weight increases in a mouse model of diet-induced obesity.{47521}
Brand:CaymanSKU:25737 - 500 µgAvailable on backorder
Brand:CaymanSKU:10006882 - 1 eaAvailable on backorder
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Brand:CaymanSKU:10006884- 1 ea Brand:CaymanSKU:10006884 - 1 eaAvailable on backorder
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