Description
Telomeric repeat binding factor (TRF2) is a ubiquitously expressed protein that is implicated in the control of telomere length.{18142} TRF2, like TRF1, contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes.{18142} TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini.{18143} The use of mutant forms of TRF2 has implicated a role of TRF2 in the prevention of senescence in primary human cells.{18143} Inhibition of TRF2 results in apoptosis in a subset of mammalian cell types.{18144}
Synonyms: Telomeric Repeat Binding Factor 2|TERF2|TRBF2|TTAGGG Repeat Binding Factor 2
Immunogen: Full length human TRF2
Formulation: 100 µg of protein G-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide
Isotype: IgG1κ
Applications: ChIP, ELISA, FC (intracellular), ICC, IF, IHC (frozen sections and paraffin-embedded tissue), IP, and WB
Origin:
Stability: 365 days
Application|ELISA||Application|Flow Cytometry||Application|Immunocytochemistry||Application|Immunofluorescence||Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Cell Death|Apoptosis
