Cayman
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Tosyllysine chloromethylketone (TLCK) is an active site-directed agent that inhibits serine proteinases with trypsin-like activity. TLCK may also act non-selectively with thiol groups and thereby inhibit cysteine proteinases and other enzymes.{13825} To prevent proteolytic degradation, TLCK may be used in protein purification protocols.{16785} TLCK selectively inactiviates clostripain obtained from C. histolyticum.{16786}
Brand:CaymanSKU:-
Totarol is a diterpene originally isolated from P. totara that has diverse biological activities, including antibacterial, antioxidant, and neuroprotective properties.{43637} It is active against Gram-positive bacteria, including P. acnes, S. mutans, B. subtilis, and B. ammoniagenes (MICs = 0.39, 0.78, 1.56, and 0.78 µg/ml, respectively), as well as penicillin-resistant and -susceptible strains of S. aureus (MICs = 0.78 and 1.56 µg/ml, respectively).{43638} It inhibits mitochondrial respiration in P. aeruginosa, inhibiting NADH-cytochrome c, NADH-DPIP, and NADH-coenzyme Q reductases but not cytochrome c oxidase.{43639} Totarol inhibits Fe(III)-ADP/NADPH-induced lipid oxidation in rat liver microsomes and mitochondria (IC50s = 4.79 and 0.47 µM, respectively) and autooxidation of linoleic acid (Item No. 90150) with an IC50 value of 9.8 µM.{43640} In rat primary cerebellar granule cells, totarol increases Akt and GSK-3β phosphorylation when used at a concentration of 5 µM and prevents neuronal death induced by glutamate or oxygen and glucose deprivation.{43641} It also reduces infarct volume in a rat model of acute cerebral ischemic injury when administered at doses of 1 and 10 microgram/kg.
Brand:CaymanSKU:26412 - 10 mgAvailable on backorder
Totarol is a diterpene originally isolated from P. totara that has diverse biological activities, including antibacterial, antioxidant, and neuroprotective properties.{43637} It is active against Gram-positive bacteria, including P. acnes, S. mutans, B. subtilis, and B. ammoniagenes (MICs = 0.39, 0.78, 1.56, and 0.78 µg/ml, respectively), as well as penicillin-resistant and -susceptible strains of S. aureus (MICs = 0.78 and 1.56 µg/ml, respectively).{43638} It inhibits mitochondrial respiration in P. aeruginosa, inhibiting NADH-cytochrome c, NADH-DPIP, and NADH-coenzyme Q reductases but not cytochrome c oxidase.{43639} Totarol inhibits Fe(III)-ADP/NADPH-induced lipid oxidation in rat liver microsomes and mitochondria (IC50s = 4.79 and 0.47 µM, respectively) and autooxidation of linoleic acid (Item No. 90150) with an IC50 value of 9.8 µM.{43640} In rat primary cerebellar granule cells, totarol increases Akt and GSK-3β phosphorylation when used at a concentration of 5 µM and prevents neuronal death induced by glutamate or oxygen and glucose deprivation.{43641} It also reduces infarct volume in a rat model of acute cerebral ischemic injury when administered at doses of 1 and 10 microgram/kg.
Brand:CaymanSKU:26412 - 25 mgAvailable on backorder
Totarol is a diterpene originally isolated from P. totara that has diverse biological activities, including antibacterial, antioxidant, and neuroprotective properties.{43637} It is active against Gram-positive bacteria, including P. acnes, S. mutans, B. subtilis, and B. ammoniagenes (MICs = 0.39, 0.78, 1.56, and 0.78 µg/ml, respectively), as well as penicillin-resistant and -susceptible strains of S. aureus (MICs = 0.78 and 1.56 µg/ml, respectively).{43638} It inhibits mitochondrial respiration in P. aeruginosa, inhibiting NADH-cytochrome c, NADH-DPIP, and NADH-coenzyme Q reductases but not cytochrome c oxidase.{43639} Totarol inhibits Fe(III)-ADP/NADPH-induced lipid oxidation in rat liver microsomes and mitochondria (IC50s = 4.79 and 0.47 µM, respectively) and autooxidation of linoleic acid (Item No. 90150) with an IC50 value of 9.8 µM.{43640} In rat primary cerebellar granule cells, totarol increases Akt and GSK-3β phosphorylation when used at a concentration of 5 µM and prevents neuronal death induced by glutamate or oxygen and glucose deprivation.{43641} It also reduces infarct volume in a rat model of acute cerebral ischemic injury when administered at doses of 1 and 10 microgram/kg.
Brand:CaymanSKU:26412 - 50 mgAvailable on backorder
Tozadenant is an adenosine A2A receptor antagonist (Kis = 11.5 and 6 nM for the human and rhesus monkey receptors, respectively).{47787} It increases the distance traveled and reduces contralateral asymmetry in the open field test in a rat model of Parkinson’s disease induced by 6-OHDA (Item No. 25330) when administered at a dose of 30 mg/kg.{47788} Tozadenant (150 mg/kg) reverses locomotor deficits and restores novel object-stimulated locomotion in a marmoset model of MPTP-induced Parkinson’s disease.{47789}
Brand:CaymanSKU:28452 - 10 mgAvailable on backorder
Tozadenant is an adenosine A2A receptor antagonist (Kis = 11.5 and 6 nM for the human and rhesus monkey receptors, respectively).{47787} It increases the distance traveled and reduces contralateral asymmetry in the open field test in a rat model of Parkinson’s disease induced by 6-OHDA (Item No. 25330) when administered at a dose of 30 mg/kg.{47788} Tozadenant (150 mg/kg) reverses locomotor deficits and restores novel object-stimulated locomotion in a marmoset model of MPTP-induced Parkinson’s disease.{47789}
Brand:CaymanSKU:28452 - 100 mgAvailable on backorder
Tozadenant is an adenosine A2A receptor antagonist (Kis = 11.5 and 6 nM for the human and rhesus monkey receptors, respectively).{47787} It increases the distance traveled and reduces contralateral asymmetry in the open field test in a rat model of Parkinson’s disease induced by 6-OHDA (Item No. 25330) when administered at a dose of 30 mg/kg.{47788} Tozadenant (150 mg/kg) reverses locomotor deficits and restores novel object-stimulated locomotion in a marmoset model of MPTP-induced Parkinson’s disease.{47789}
Brand:CaymanSKU:28452 - 25 mgAvailable on backorder
Tozadenant is an adenosine A2A receptor antagonist (Kis = 11.5 and 6 nM for the human and rhesus monkey receptors, respectively).{47787} It increases the distance traveled and reduces contralateral asymmetry in the open field test in a rat model of Parkinson’s disease induced by 6-OHDA (Item No. 25330) when administered at a dose of 30 mg/kg.{47788} Tozadenant (150 mg/kg) reverses locomotor deficits and restores novel object-stimulated locomotion in a marmoset model of MPTP-induced Parkinson’s disease.{47789}
Brand:CaymanSKU:28452 - 50 mgAvailable on backorder
Immunogen: Synthetic peptide from the C-terminal region of human TP receptor • Host: Rabbit • Species Reactivity: (+) human, COS-7 (African green monkey), mouse, and rat • Applications: ICC, IHC, and WB • The TP receptor is a GPCR that mediates the action of TXA2
Brand:CaymanSKU:10004452- 1 eaAvailable on backorder
Immunogen: Synthetic peptide from the C-terminal region of human TP receptor • Host: Rabbit • Species Reactivity: (+) human, COS-7 (African green monkey), mouse, and rat • Applications: ICC, IHC, and WB • The TP receptor is a GPCR that mediates the action of TXA2
Brand:CaymanSKU:10004452- 1 ea Thromboxane A2 (TXA2) is a potent vasoconstrictor and activator of platelet aggregation. TXA2 elicits its effects via a 7-transmembrane domain G protein-coupled receptor, the TP receptor.{3168} The TP receptor is highly expressed in platelets and is relatively less abundant in tissues such as lung, kidney, brain, spleen, thymus, monocytes, uterus, and placenta.{3167,11368,2061,4311} The apparent molecular weight for TP receptors has been reported from 37 kDa to 70 kDa, depending on different degrees of glycosylation.{8380,4311,7235} However Cayman’s antibody consistently detects the TP receptor at 55 and 64 kDa in platelet, kidney, and Cos-7 cell samples. Cayman Chemical’s TP receptor polyclonal antibody can be used for western blot and immunocytochemical analysis for both the TPA and TPB splice variants of the receptor on samples of human, murine, rat, and COS-7 (African green monkey) origin.
Brand:CaymanSKU:10004452 - 1 eaAvailable on backorder
Immunogen: Synthetic peptide from the C-terminal region of human TP • Host: Rabbit • Species Reactivity: (+) Human, African green monkey, mouse, and rat • Application: FC • The TP receptor is a GPCR that mediates the action of TXA2.
Brand:CaymanSKU:10012559- 1 ea Thromboxane A2 (TXA2) is a potent vasoconstrictor and activator of platelet aggregation. The short half-life of TXA2 ensures local action whether generated by vascular endothelial cells or by platelets and confers physiologically beneficial or deleterious effects under inflammatory situations.{146,11131} TXA2 elicits its effects via a 7-transmembrane domain G protein-coupled receptor, the TP receptor.{6062} This receptor can also bind prostaglandin H2 and isoprostanes and was first cloned from human placenta and the platelet-like MEG-01 cell line.{11146,7729} The TP receptor is highly expressed in platelets and is relatively less abundant in tissues such as lung, kidney, brain, spleen, thymus, monocytes, uterus, and placenta.{3167,11368,2061,4311,8380,7235}
Brand:CaymanSKU:10012559 - 1 eaAvailable on backorder
Immunogen: Synthetic peptide from the C-terminal region of human TP • Host: Rabbit • Species Reactivity: (+) Human, African green monkey, mouse, and rat • Application: FC • The TP receptor is a GPCR that mediates the action of TXA2.
Brand:CaymanSKU:10012559- 1 eaAvailable on backorder
Immunogen: Synthetic peptide from an internal region of mouse TP receptor • Host: Rabbit • Species Reactivity: (+) Human, bovine, African green monkey, mouse, and rat TP receptor • Application(s): WB • The TP receptor is a GPCR that mediates the action of TXA2.
Brand:CaymanSKU:101882- 1 ea Thromboxane A2 (TXA2) is a potent vasoconstrictor and activator of platelet aggregation. TXA2 elicits its effects via a 7-transmembrane domain G-protein coupled receptor, the TP receptor.{6062} The TP receptor is highly expressed in platelets and is relatively less abundant in tissues such as lung, kidney, brain, spleen, thymus, monocytes, uterus, and placenta.{3167,11368,2061,4311} The apparent molecular weight for TP receptors has been reported from 37 kDa to 70 kDa, depending on different degrees of glycosylation.{8380,4311,7235} However, Cayman’s antibody consistently detects the TP receptor at 42 kDa in kidney, Hep2, and COS-7 cell samples. Cayman’s TP receptor polyclonal antibody can be used for Western blot analysis for both the TPA and TPB splice variants of the receptor on samples of human, mouse, rat, monkey and bovine origin. Use of this antibody for other species and applications has not yet been tested.
Brand:CaymanSKU:101882 - 1 eaAvailable on backorder
Immunogen: Synthetic peptide from an internal region of mouse TP receptor • Host: Rabbit • Species Reactivity: (+) Human, bovine, African green monkey, mouse, and rat TP receptor • Application(s): WB • The TP receptor is a GPCR that mediates the action of TXA2.
Brand:CaymanSKU:101882- 1 eaAvailable on backorder
TP-064 is a potent inhibitor of protein arginine methyltransferase 4 (PRMT4; IC50 50 = 43 nM) in vitro. For more information on TP-064 please visit the Structural Genomics Consortium (SGC). The negative control, TP-064N, for TP-064 is also available exclusively through the SGC. You can submit a request to receive the negative control here.
Brand:CaymanSKU:20256 -Available on backorder
TP-064 is a potent inhibitor of protein arginine methyltransferase 4 (PRMT4; IC50 50 = 43 nM) in vitro. For more information on TP-064 please visit the Structural Genomics Consortium (SGC). The negative control, TP-064N, for TP-064 is also available exclusively through the SGC. You can submit a request to receive the negative control here.
Brand:CaymanSKU:20256 -Available on backorder
TP-064 is a potent inhibitor of protein arginine methyltransferase 4 (PRMT4; IC50 50 = 43 nM) in vitro. For more information on TP-064 please visit the Structural Genomics Consortium (SGC). The negative control, TP-064N, for TP-064 is also available exclusively through the SGC. You can submit a request to receive the negative control here.
Brand:CaymanSKU:20256 -Available on backorder
TP-064 is a potent inhibitor of protein arginine methyltransferase 4 (PRMT4; IC50 50 = 43 nM) in vitro. For more information on TP-064 please visit the Structural Genomics Consortium (SGC). The negative control, TP-064N, for TP-064 is also available exclusively through the SGC. You can submit a request to receive the negative control here.
Brand:CaymanSKU:20256 -Available on backorder
TP-0903 is an inhibitor of the receptor tyrosine kinase Axl (IC50 = 27 nM ).{53037} It exhibits greater than 50% inhibition of 11 kinases, including MER, TYRO3, JAK2, ALK, and Abl1, in a panel of 75 kinases at 200 nM, with IC50 values of 3 and 12.4 nM for Aurora A and B, respectively. TP-0903 decreases the phosphorylation of Akt and Axl in GAS6-stimulated, serum-starved PSN-1 pancreatic cancer cells (EC50s = 305 and 222 nM, respectively). It decreases cell viability (IC50 = 6 nM) and induces cell cycle arrest at the G2/M phase in PSN-1 cells when used at a concentration of 30 nM. TP-0903 also reduces the viability of colorectal cancer (CRC) cell lines with IC50 values ranging from 4.5 to 123 nM.{53038} It exhibits 69 and 44% tumor growth inhibition in an HCT116 mouse xenograft model and a K-Ras-mutant CRC patient-derived xenograft (PDX) mouse model, respectively, when administered at a dose of 40 mg/kg.
Brand:CaymanSKU:28757 - 1 mgAvailable on backorder
TP-0903 is an inhibitor of the receptor tyrosine kinase Axl (IC50 = 27 nM ).{53037} It exhibits greater than 50% inhibition of 11 kinases, including MER, TYRO3, JAK2, ALK, and Abl1, in a panel of 75 kinases at 200 nM, with IC50 values of 3 and 12.4 nM for Aurora A and B, respectively. TP-0903 decreases the phosphorylation of Akt and Axl in GAS6-stimulated, serum-starved PSN-1 pancreatic cancer cells (EC50s = 305 and 222 nM, respectively). It decreases cell viability (IC50 = 6 nM) and induces cell cycle arrest at the G2/M phase in PSN-1 cells when used at a concentration of 30 nM. TP-0903 also reduces the viability of colorectal cancer (CRC) cell lines with IC50 values ranging from 4.5 to 123 nM.{53038} It exhibits 69 and 44% tumor growth inhibition in an HCT116 mouse xenograft model and a K-Ras-mutant CRC patient-derived xenograft (PDX) mouse model, respectively, when administered at a dose of 40 mg/kg.
Brand:CaymanSKU:28757 - 10 mgAvailable on backorder
TP-0903 is an inhibitor of the receptor tyrosine kinase Axl (IC50 = 27 nM ).{53037} It exhibits greater than 50% inhibition of 11 kinases, including MER, TYRO3, JAK2, ALK, and Abl1, in a panel of 75 kinases at 200 nM, with IC50 values of 3 and 12.4 nM for Aurora A and B, respectively. TP-0903 decreases the phosphorylation of Akt and Axl in GAS6-stimulated, serum-starved PSN-1 pancreatic cancer cells (EC50s = 305 and 222 nM, respectively). It decreases cell viability (IC50 = 6 nM) and induces cell cycle arrest at the G2/M phase in PSN-1 cells when used at a concentration of 30 nM. TP-0903 also reduces the viability of colorectal cancer (CRC) cell lines with IC50 values ranging from 4.5 to 123 nM.{53038} It exhibits 69 and 44% tumor growth inhibition in an HCT116 mouse xenograft model and a K-Ras-mutant CRC patient-derived xenograft (PDX) mouse model, respectively, when administered at a dose of 40 mg/kg.
Brand:CaymanSKU:28757 - 25 mgAvailable on backorder
TP-0903 is an inhibitor of the receptor tyrosine kinase Axl (IC50 = 27 nM ).{53037} It exhibits greater than 50% inhibition of 11 kinases, including MER, TYRO3, JAK2, ALK, and Abl1, in a panel of 75 kinases at 200 nM, with IC50 values of 3 and 12.4 nM for Aurora A and B, respectively. TP-0903 decreases the phosphorylation of Akt and Axl in GAS6-stimulated, serum-starved PSN-1 pancreatic cancer cells (EC50s = 305 and 222 nM, respectively). It decreases cell viability (IC50 = 6 nM) and induces cell cycle arrest at the G2/M phase in PSN-1 cells when used at a concentration of 30 nM. TP-0903 also reduces the viability of colorectal cancer (CRC) cell lines with IC50 values ranging from 4.5 to 123 nM.{53038} It exhibits 69 and 44% tumor growth inhibition in an HCT116 mouse xenograft model and a K-Ras-mutant CRC patient-derived xenograft (PDX) mouse model, respectively, when administered at a dose of 40 mg/kg.
Brand:CaymanSKU:28757 - 5 mgAvailable on backorder
TP-238 is a chemical probe for the bromodomains of cat eye syndrome chromosome region, candidate 2 (CECR2) and bromodomain PHD finger transcription factor (BPTF). It has on-target biochemical activity with CECR2 when used at concentrations ranging from 10 to 30 nM and with BPTF at concentrations ranging from 100 to 350 nM. It is selective for the CECR2 and BPTF bromodomains over BRD9 (IC50 = 1.4 µM), as well as over a panel of 338 kinases at 1 µM. TP-238 binds to CECR2 and BPTF with KD values of 10 and 120 nM, respectively, in an isothermal titration calorimetry (ITC) assay and IC50 values of 30 and 350 nM, respectively, in an AlphaScreen® assay. See the Structural Genomics Consortium (SGC) website for more information.
Brand:CaymanSKU:27254 - 1 mgAvailable on backorder
TP-238 is a chemical probe for the bromodomains of cat eye syndrome chromosome region, candidate 2 (CECR2) and bromodomain PHD finger transcription factor (BPTF). It has on-target biochemical activity with CECR2 when used at concentrations ranging from 10 to 30 nM and with BPTF at concentrations ranging from 100 to 350 nM. It is selective for the CECR2 and BPTF bromodomains over BRD9 (IC50 = 1.4 µM), as well as over a panel of 338 kinases at 1 µM. TP-238 binds to CECR2 and BPTF with KD values of 10 and 120 nM, respectively, in an isothermal titration calorimetry (ITC) assay and IC50 values of 30 and 350 nM, respectively, in an AlphaScreen® assay. See the Structural Genomics Consortium (SGC) website for more information.
Brand:CaymanSKU:27254 - 10 mgAvailable on backorder
TP-238 is a chemical probe for the bromodomains of cat eye syndrome chromosome region, candidate 2 (CECR2) and bromodomain PHD finger transcription factor (BPTF). It has on-target biochemical activity with CECR2 when used at concentrations ranging from 10 to 30 nM and with BPTF at concentrations ranging from 100 to 350 nM. It is selective for the CECR2 and BPTF bromodomains over BRD9 (IC50 = 1.4 µM), as well as over a panel of 338 kinases at 1 µM. TP-238 binds to CECR2 and BPTF with KD values of 10 and 120 nM, respectively, in an isothermal titration calorimetry (ITC) assay and IC50 values of 30 and 350 nM, respectively, in an AlphaScreen® assay. See the Structural Genomics Consortium (SGC) website for more information.
Brand:CaymanSKU:27254 - 5 mgAvailable on backorder
TP-3654 is an inhibitor of Pim kinases (Kis = 5, 239, and 42 nM for Pim-1, Pim-2, and Pim-3, respectively).{45703} It inhibits 19 additional kinases, including PI3Kα, PI3Kγ, and PI3Kδ, with IC50 values of less than 300 nM. TP-3654 inhibits phosphorylation of Bad in HEK293 cells overexpressing Bad and Pim-1 (EC50 = 67 nM), as well as in UM-UC-3 cells. It reduces tumor growth in UM-UC-3 bladder carcinoma and PC3 prostate adenocarcinoma mouse xenograft models when administered at a dose of 200 mg/kg.
Brand:CaymanSKU:29571 - 10 mgAvailable on backorder
TP-3654 is an inhibitor of Pim kinases (Kis = 5, 239, and 42 nM for Pim-1, Pim-2, and Pim-3, respectively).{45703} It inhibits 19 additional kinases, including PI3Kα, PI3Kγ, and PI3Kδ, with IC50 values of less than 300 nM. TP-3654 inhibits phosphorylation of Bad in HEK293 cells overexpressing Bad and Pim-1 (EC50 = 67 nM), as well as in UM-UC-3 cells. It reduces tumor growth in UM-UC-3 bladder carcinoma and PC3 prostate adenocarcinoma mouse xenograft models when administered at a dose of 200 mg/kg.
Brand:CaymanSKU:29571 - 25 mgAvailable on backorder
TP-3654 is an inhibitor of Pim kinases (Kis = 5, 239, and 42 nM for Pim-1, Pim-2, and Pim-3, respectively).{45703} It inhibits 19 additional kinases, including PI3Kα, PI3Kγ, and PI3Kδ, with IC50 values of less than 300 nM. TP-3654 inhibits phosphorylation of Bad in HEK293 cells overexpressing Bad and Pim-1 (EC50 = 67 nM), as well as in UM-UC-3 cells. It reduces tumor growth in UM-UC-3 bladder carcinoma and PC3 prostate adenocarcinoma mouse xenograft models when administered at a dose of 200 mg/kg.
Brand:CaymanSKU:29571 - 5 mgAvailable on backorder
TP-472 is an inhibitor of bromodomain BRD9 (Kd = 33 nM; EC50 = 320 nM in a NanoBRET assay). It has >30-fold selectivity over all other bromodomain family members with the exception of the highly homologous BRD7 bromodomain (Kd = 340 nM in an isothermal titration calorimetry (ITC) assay). See the Structural Genomic Consortium (SGC) website for more information.
Brand:CaymanSKU:20030 -Available on backorder
TP-472 is an inhibitor of bromodomain BRD9 (Kd = 33 nM; EC50 = 320 nM in a NanoBRET assay). It has >30-fold selectivity over all other bromodomain family members with the exception of the highly homologous BRD7 bromodomain (Kd = 340 nM in an isothermal titration calorimetry (ITC) assay). See the Structural Genomic Consortium (SGC) website for more information.
Brand:CaymanSKU:20030 -Available on backorder
TP-4748 is a heterocyclic building block.{52779} It has been used in the synthesis of prolyl-tRNA synthase inhibitors.
Brand:CaymanSKU:31459 - 10 mgAvailable on backorder
TP-4748 is a heterocyclic building block.{52779} It has been used in the synthesis of prolyl-tRNA synthase inhibitors.
Brand:CaymanSKU:31459 - 25 mgAvailable on backorder
TP-4748 is a heterocyclic building block.{52779} It has been used in the synthesis of prolyl-tRNA synthase inhibitors.
Brand:CaymanSKU:31459 - 50 mgAvailable on backorder
Brand:CaymanSKU:24181 - 10 mgAvailable on backorder
Brand:CaymanSKU:24181 - 25 mgAvailable on backorder
Brand:CaymanSKU:24181 - 5 mgAvailable on backorder
Brand:CaymanSKU:24181 - 50 mgAvailable on backorder
TPCA-1 is a selective inhibitor of IκB kinase-2 (IC50s = 17.9 nM and 0.40 μM for IKK2 and IKK1, respectively).{24239} Furthermore, it displays greater than 550-fold selectivity over other kinases and enzymes including, p38, MAPK, COX, and JNK.{24239} TPCA-1 inhibits the production of LPS-induced TNF-α, IL-6, and IL-8 with IC50 values equal to 0.17, 0.29, and 0.32 μM, respectively.{24239} At 20 mg/kg, TPCA-1 has been used to reduce the severity and onset of collagen-induced arthritis in mice and at 30 mg/kg to block cytokine release in an antigen-driven rat model of lung inflammation.{24239,24240}
Brand:CaymanSKU:- TPCA-1 is a selective inhibitor of IκB kinase-2 (IC50s = 17.9 nM and 0.40 μM for IKK2 and IKK1, respectively).{24239} Furthermore, it displays greater than 550-fold selectivity over other kinases and enzymes including, p38, MAPK, COX, and JNK.{24239} TPCA-1 inhibits the production of LPS-induced TNF-α, IL-6, and IL-8 with IC50 values equal to 0.17, 0.29, and 0.32 μM, respectively.{24239} At 20 mg/kg, TPCA-1 has been used to reduce the severity and onset of collagen-induced arthritis in mice and at 30 mg/kg to block cytokine release in an antigen-driven rat model of lung inflammation.{24239,24240}
Brand:CaymanSKU:- TPCA-1 is a selective inhibitor of IκB kinase-2 (IC50s = 17.9 nM and 0.40 μM for IKK2 and IKK1, respectively).{24239} Furthermore, it displays greater than 550-fold selectivity over other kinases and enzymes including, p38, MAPK, COX, and JNK.{24239} TPCA-1 inhibits the production of LPS-induced TNF-α, IL-6, and IL-8 with IC50 values equal to 0.17, 0.29, and 0.32 μM, respectively.{24239} At 20 mg/kg, TPCA-1 has been used to reduce the severity and onset of collagen-induced arthritis in mice and at 30 mg/kg to block cytokine release in an antigen-driven rat model of lung inflammation.{24239,24240}
Brand:CaymanSKU:- TPCA-1 is a selective inhibitor of IκB kinase-2 (IC50s = 17.9 nM and 0.40 μM for IKK2 and IKK1, respectively).{24239} Furthermore, it displays greater than 550-fold selectivity over other kinases and enzymes including, p38, MAPK, COX, and JNK.{24239} TPCA-1 inhibits the production of LPS-induced TNF-α, IL-6, and IL-8 with IC50 values equal to 0.17, 0.29, and 0.32 μM, respectively.{24239} At 20 mg/kg, TPCA-1 has been used to reduce the severity and onset of collagen-induced arthritis in mice and at 30 mg/kg to block cytokine release in an antigen-driven rat model of lung inflammation.{24239,24240}
Brand:CaymanSKU:-
As a cofactor of more than 300 enzymes, zinc is integral for a wide variety of cellular processes that affect most biological functions.{18326} Most notably, its bioavailability is important to the regulation of apoptosis, cell proliferation, and differentiation. TPEN is a cell permeant metal ion chelator that is used in zinc treatment studies to limit intra- and extracellular concentrations of the mineral.{18327} At a concentration as low as 6 µM, TPEN-induced zinc depletion decreases X-linked inhibitor of apoptosis (XIAP) levels in human PC-3 prostate cancer cells and promotes caspase-3 and -9 activation.{18324} At 25 µM, TPEN attenuates hypoxic pulmonary vasoconstriction in rodent isolated perfused lung.{18325}
Brand:CaymanSKU:- As a cofactor of more than 300 enzymes, zinc is integral for a wide variety of cellular processes that affect most biological functions.{18326} Most notably, its bioavailability is important to the regulation of apoptosis, cell proliferation, and differentiation. TPEN is a cell permeant metal ion chelator that is used in zinc treatment studies to limit intra- and extracellular concentrations of the mineral.{18327} At a concentration as low as 6 µM, TPEN-induced zinc depletion decreases X-linked inhibitor of apoptosis (XIAP) levels in human PC-3 prostate cancer cells and promotes caspase-3 and -9 activation.{18324} At 25 µM, TPEN attenuates hypoxic pulmonary vasoconstriction in rodent isolated perfused lung.{18325}
Brand:CaymanSKU:- As a cofactor of more than 300 enzymes, zinc is integral for a wide variety of cellular processes that affect most biological functions.{18326} Most notably, its bioavailability is important to the regulation of apoptosis, cell proliferation, and differentiation. TPEN is a cell permeant metal ion chelator that is used in zinc treatment studies to limit intra- and extracellular concentrations of the mineral.{18327} At a concentration as low as 6 µM, TPEN-induced zinc depletion decreases X-linked inhibitor of apoptosis (XIAP) levels in human PC-3 prostate cancer cells and promotes caspase-3 and -9 activation.{18324} At 25 µM, TPEN attenuates hypoxic pulmonary vasoconstriction in rodent isolated perfused lung.{18325}
Brand:CaymanSKU:- As a cofactor of more than 300 enzymes, zinc is integral for a wide variety of cellular processes that affect most biological functions.{18326} Most notably, its bioavailability is important to the regulation of apoptosis, cell proliferation, and differentiation. TPEN is a cell permeant metal ion chelator that is used in zinc treatment studies to limit intra- and extracellular concentrations of the mineral.{18327} At a concentration as low as 6 µM, TPEN-induced zinc depletion decreases X-linked inhibitor of apoptosis (XIAP) levels in human PC-3 prostate cancer cells and promotes caspase-3 and -9 activation.{18324} At 25 µM, TPEN attenuates hypoxic pulmonary vasoconstriction in rodent isolated perfused lung.{18325}
Brand:CaymanSKU:-
TPI-1 is an inhibitor of protein tyrosine phosphatases.{41578} TPI-1 (10 ng/ml) increases phosphorylated substrates of the phosphatase SHP-1 in Jurkat T cells, including pLck-pY394, pZap70, and pSlp76. It is selective for SHP-1 over SHP-2, having low activity at the SHP-2 substrate pERK1/2. It increases pLck-pY394 levels by approximately 3.3-fold and increases the number of IFN-γ+ cells in mouse spleen ex vivo following a dose of approximately 3 mg/kg. Oral administration of TPI-1 (3 mg/kg per day) inhibits tumor growth in a B16 melanoma mouse xenograft model.
Brand:CaymanSKU:22480 -Out of stock
TPI-1 is an inhibitor of protein tyrosine phosphatases.{41578} TPI-1 (10 ng/ml) increases phosphorylated substrates of the phosphatase SHP-1 in Jurkat T cells, including pLck-pY394, pZap70, and pSlp76. It is selective for SHP-1 over SHP-2, having low activity at the SHP-2 substrate pERK1/2. It increases pLck-pY394 levels by approximately 3.3-fold and increases the number of IFN-γ+ cells in mouse spleen ex vivo following a dose of approximately 3 mg/kg. Oral administration of TPI-1 (3 mg/kg per day) inhibits tumor growth in a B16 melanoma mouse xenograft model.
Brand:CaymanSKU:22480 -Out of stock
TPI-1 is an inhibitor of protein tyrosine phosphatases.{41578} TPI-1 (10 ng/ml) increases phosphorylated substrates of the phosphatase SHP-1 in Jurkat T cells, including pLck-pY394, pZap70, and pSlp76. It is selective for SHP-1 over SHP-2, having low activity at the SHP-2 substrate pERK1/2. It increases pLck-pY394 levels by approximately 3.3-fold and increases the number of IFN-γ+ cells in mouse spleen ex vivo following a dose of approximately 3 mg/kg. Oral administration of TPI-1 (3 mg/kg per day) inhibits tumor growth in a B16 melanoma mouse xenograft model.
Brand:CaymanSKU:22480 -Out of stock
TPI-1 is an inhibitor of protein tyrosine phosphatases.{41578} TPI-1 (10 ng/ml) increases phosphorylated substrates of the phosphatase SHP-1 in Jurkat T cells, including pLck-pY394, pZap70, and pSlp76. It is selective for SHP-1 over SHP-2, having low activity at the SHP-2 substrate pERK1/2. It increases pLck-pY394 levels by approximately 3.3-fold and increases the number of IFN-γ+ cells in mouse spleen ex vivo following a dose of approximately 3 mg/kg. Oral administration of TPI-1 (3 mg/kg per day) inhibits tumor growth in a B16 melanoma mouse xenograft model.
Brand:CaymanSKU:22480 -Out of stock
Tpl2 kinase inhibitor is a reversible inhibitor of tumor progression locus 2 (Tpl2; pIC50 = 7.3).{32782} It blocks LPS-induced TNF-α production in mice and human monocytes.{32782,32783} Tpl2 kinase inhibitor has been used to evaluate the role of this enzyme in the proliferation and differentiation of cancer cells.{32784,32785}
Brand:CaymanSKU:19710 -Available on backorder
Tpl2 kinase inhibitor is a reversible inhibitor of tumor progression locus 2 (Tpl2; pIC50 = 7.3).{32782} It blocks LPS-induced TNF-α production in mice and human monocytes.{32782,32783} Tpl2 kinase inhibitor has been used to evaluate the role of this enzyme in the proliferation and differentiation of cancer cells.{32784,32785}
Brand:CaymanSKU:19710 -Available on backorder
Tpl2 kinase inhibitor is a reversible inhibitor of tumor progression locus 2 (Tpl2; pIC50 = 7.3).{32782} It blocks LPS-induced TNF-α production in mice and human monocytes.{32782,32783} Tpl2 kinase inhibitor has been used to evaluate the role of this enzyme in the proliferation and differentiation of cancer cells.{32784,32785}
Brand:CaymanSKU:19710 -Available on backorder
Tpl2 kinase inhibitor is a reversible inhibitor of tumor progression locus 2 (Tpl2; pIC50 = 7.3).{32782} It blocks LPS-induced TNF-α production in mice and human monocytes.{32782,32783} Tpl2 kinase inhibitor has been used to evaluate the role of this enzyme in the proliferation and differentiation of cancer cells.{32784,32785}
Brand:CaymanSKU:19710 -Available on backorder
Soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols. Inhibitors of sEH have anti-inflammatory, anti-hypertensive, neuroprotective, and cardioprotective effects.{14072,12607} TPPU is a potent inhibitor of both human and mouse sEH (IC50 = 3.7 and 2.8 nM, respectively).{18630} The pharmacokinetics of this compound are dramatically superior to those of the 1-adamantylurea based inhibitors, like AUDA.{18630,20116}
Brand:CaymanSKU:11120 - 1 mgAvailable on backorder
Soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols. Inhibitors of sEH have anti-inflammatory, anti-hypertensive, neuroprotective, and cardioprotective effects.{14072,12607} TPPU is a potent inhibitor of both human and mouse sEH (IC50 = 3.7 and 2.8 nM, respectively).{18630} The pharmacokinetics of this compound are dramatically superior to those of the 1-adamantylurea based inhibitors, like AUDA.{18630,20116}
Brand:CaymanSKU:11120 - 10 mgAvailable on backorder
Soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols. Inhibitors of sEH have anti-inflammatory, anti-hypertensive, neuroprotective, and cardioprotective effects.{14072,12607} TPPU is a potent inhibitor of both human and mouse sEH (IC50 = 3.7 and 2.8 nM, respectively).{18630} The pharmacokinetics of this compound are dramatically superior to those of the 1-adamantylurea based inhibitors, like AUDA.{18630,20116}
Brand:CaymanSKU:11120 - 25 mgAvailable on backorder
Soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols. Inhibitors of sEH have anti-inflammatory, anti-hypertensive, neuroprotective, and cardioprotective effects.{14072,12607} TPPU is a potent inhibitor of both human and mouse sEH (IC50 = 3.7 and 2.8 nM, respectively).{18630} The pharmacokinetics of this compound are dramatically superior to those of the 1-adamantylurea based inhibitors, like AUDA.{18630,20116}
Brand:CaymanSKU:11120 - 5 mgAvailable on backorder
Retromers are multiprotein complexes responsible for trafficking cargo out of endosomes. This is an important function that, in the case of amyloid-precursor protein (APP), is neuroprotective by preventing APP from being cleaved into Alzheimer’s disease-inducing fragments via the endosome. TPT-260 is a thiophene thiourea derivative that acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~5 µM).{25946} In cultured hippocampal neurons, TPT-260 dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP.{25946}
Brand:CaymanSKU:- Retromers are multiprotein complexes responsible for trafficking cargo out of endosomes. This is an important function that, in the case of amyloid-precursor protein (APP), is neuroprotective by preventing APP from being cleaved into Alzheimer’s disease-inducing fragments via the endosome. TPT-260 is a thiophene thiourea derivative that acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~5 µM).{25946} In cultured hippocampal neurons, TPT-260 dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP.{25946}
Brand:CaymanSKU:- Retromers are multiprotein complexes responsible for trafficking cargo out of endosomes. This is an important function that, in the case of amyloid-precursor protein (APP), is neuroprotective by preventing APP from being cleaved into Alzheimer’s disease-inducing fragments via the endosome. TPT-260 is a thiophene thiourea derivative that acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~5 µM).{25946} In cultured hippocampal neurons, TPT-260 dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP.{25946}
Brand:CaymanSKU:- Retromers are multiprotein complexes responsible for trafficking cargo out of endosomes. This is an important function that, in the case of amyloid-precursor protein (APP), is neuroprotective by preventing APP from being cleaved into Alzheimer’s disease-inducing fragments via the endosome. TPT-260 is a thiophene thiourea derivative that acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~5 µM).{25946} In cultured hippocampal neurons, TPT-260 dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP.{25946}
Brand:CaymanSKU:-
TPTZ is a colorimetric reagent commonly used in the detection of iron.{50357,50358} TPTZ forms a complex with Fe(II) that can be quantified by colorimetric detection at 594 nm as a measure of iron concentration.
Brand:CaymanSKU:28274 - 1 gAvailable on backorder
TPTZ is a colorimetric reagent commonly used in the detection of iron.{50357,50358} TPTZ forms a complex with Fe(II) that can be quantified by colorimetric detection at 594 nm as a measure of iron concentration.
Brand:CaymanSKU:28274 - 10 gAvailable on backorder
TPTZ is a colorimetric reagent commonly used in the detection of iron.{50357,50358} TPTZ forms a complex with Fe(II) that can be quantified by colorimetric detection at 594 nm as a measure of iron concentration.
Brand:CaymanSKU:28274 - 25 gAvailable on backorder
TPTZ is a colorimetric reagent commonly used in the detection of iron.{50357,50358} TPTZ forms a complex with Fe(II) that can be quantified by colorimetric detection at 594 nm as a measure of iron concentration.
Brand:CaymanSKU:28274 - 5 gAvailable on backorder
TPU-0037A is an antibiotic and a congener of lydicamycin (Item No. 20584).{36353} It inhibits the growth of Gram-positive bacteria, including methicillin-resistant S. aureus (MRSA), B. subtilis, and M. luteus (MICs = 1.56-12.5 μg/ml), but not Gram-negative E. coli, P. mirabilis, P. vulgaris, or P. aeruginosa strains (MICs = >50 μg/ml).
Brand:CaymanSKU:25761 - 2.5 mgAvailable on backorder
TPU-0037A is an antibiotic and a congener of lydicamycin (Item No. 20584).{36353} It inhibits the growth of Gram-positive bacteria, including methicillin-resistant S. aureus (MRSA), B. subtilis, and M. luteus (MICs = 1.56-12.5 μg/ml), but not Gram-negative E. coli, P. mirabilis, P. vulgaris, or P. aeruginosa strains (MICs = >50 μg/ml).
Brand:CaymanSKU:25761 - 500 µgAvailable on backorder
TPU-0037C is a metabolite of the marine actinomycete S. platensis that is structurally similar to lydicamycin (Item No. 20584).{36353} It is active against Gram-positive bacteria (MICs = 0.39-3.13 µg/ml), including methicillin-resistant S. aureus strains (MIC = 3.13 µg/ml), but is ineffective against Gram-negative bacteria (MICs = >50 µg/ml).
Brand:CaymanSKU:24179 - 2.5 mgAvailable on backorder
TPU-0037C is a metabolite of the marine actinomycete S. platensis that is structurally similar to lydicamycin (Item No. 20584).{36353} It is active against Gram-positive bacteria (MICs = 0.39-3.13 µg/ml), including methicillin-resistant S. aureus strains (MIC = 3.13 µg/ml), but is ineffective against Gram-negative bacteria (MICs = >50 µg/ml).
Brand:CaymanSKU:24179 - 500 µgAvailable on backorder
TPX-0005 is a multi-kinase inhibitor that inhibits TrkA, TrkB, and TrkC (IC50s = 0.83, 0.05, and 0.1 nM, respectively) as well as C-ros oncogene 1 (ROS1; IC50 = 0.07 nM).{36850} It inhibits a variety of other kinases, including ALK, JAK2, LYN, Src, and FAK (IC50s = 1.04, 1.04, 1.66, 5.3, and 6.96 nM, respectively). It inhibits proliferation of PC-9, H1975, 11-18, HCC4006, and HCC827 lung cancer cells (IC50s = 100, 100, 150, 148, and 430 nM, respectively) with additive or synergistic effects when used in combination with gefitinib (Item No. 13166), afatinib (Item No. 11492), PF-299804 (dacomitinib; Item No. 9001879), or osimertinib. TPX-0005 (30 mg/kg) reduces tumor growth in PC-9 and H1975 mouse xenograft models and potentiates the effect of osimertinib in these models.
Brand:CaymanSKU:23397 - 1 mgAvailable on backorder
TPX-0005 is a multi-kinase inhibitor that inhibits TrkA, TrkB, and TrkC (IC50s = 0.83, 0.05, and 0.1 nM, respectively) as well as C-ros oncogene 1 (ROS1; IC50 = 0.07 nM).{36850} It inhibits a variety of other kinases, including ALK, JAK2, LYN, Src, and FAK (IC50s = 1.04, 1.04, 1.66, 5.3, and 6.96 nM, respectively). It inhibits proliferation of PC-9, H1975, 11-18, HCC4006, and HCC827 lung cancer cells (IC50s = 100, 100, 150, 148, and 430 nM, respectively) with additive or synergistic effects when used in combination with gefitinib (Item No. 13166), afatinib (Item No. 11492), PF-299804 (dacomitinib; Item No. 9001879), or osimertinib. TPX-0005 (30 mg/kg) reduces tumor growth in PC-9 and H1975 mouse xenograft models and potentiates the effect of osimertinib in these models.
Brand:CaymanSKU:23397 - 10 mgAvailable on backorder
TPX-0005 is a multi-kinase inhibitor that inhibits TrkA, TrkB, and TrkC (IC50s = 0.83, 0.05, and 0.1 nM, respectively) as well as C-ros oncogene 1 (ROS1; IC50 = 0.07 nM).{36850} It inhibits a variety of other kinases, including ALK, JAK2, LYN, Src, and FAK (IC50s = 1.04, 1.04, 1.66, 5.3, and 6.96 nM, respectively). It inhibits proliferation of PC-9, H1975, 11-18, HCC4006, and HCC827 lung cancer cells (IC50s = 100, 100, 150, 148, and 430 nM, respectively) with additive or synergistic effects when used in combination with gefitinib (Item No. 13166), afatinib (Item No. 11492), PF-299804 (dacomitinib; Item No. 9001879), or osimertinib. TPX-0005 (30 mg/kg) reduces tumor growth in PC-9 and H1975 mouse xenograft models and potentiates the effect of osimertinib in these models.
Brand:CaymanSKU:23397 - 25 mgAvailable on backorder
TPX-0005 is a multi-kinase inhibitor that inhibits TrkA, TrkB, and TrkC (IC50s = 0.83, 0.05, and 0.1 nM, respectively) as well as C-ros oncogene 1 (ROS1; IC50 = 0.07 nM).{36850} It inhibits a variety of other kinases, including ALK, JAK2, LYN, Src, and FAK (IC50s = 1.04, 1.04, 1.66, 5.3, and 6.96 nM, respectively). It inhibits proliferation of PC-9, H1975, 11-18, HCC4006, and HCC827 lung cancer cells (IC50s = 100, 100, 150, 148, and 430 nM, respectively) with additive or synergistic effects when used in combination with gefitinib (Item No. 13166), afatinib (Item No. 11492), PF-299804 (dacomitinib; Item No. 9001879), or osimertinib. TPX-0005 (30 mg/kg) reduces tumor growth in PC-9 and H1975 mouse xenograft models and potentiates the effect of osimertinib in these models.
Brand:CaymanSKU:23397 - 5 mgAvailable on backorder
Brand:CaymanSKU:600503 - 10 mlAvailable on backorder
Brand:CaymanSKU:600503 - 2 mlAvailable on backorder
Brand:CaymanSKU:600508 - 10 mlAvailable on backorder
Brand:CaymanSKU:600508 - 2 mlAvailable on backorder
Brand:CaymanSKU:600504 - 1 gAvailable on backorder