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Thienyl fentanyl (hydrochloride) (Item No. 20785) is an analytical reference standard that is structurally categorized as an opioid. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:20785 -Available on backorder
Thienyl fentanyl (hydrochloride) (Item No. 20785) is an analytical reference standard that is structurally categorized as an opioid. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:20785 -Available on backorder
Thienyldecyl isothiocyanate is an analog of thienylbutyl isothiocyanate that, like many isothiocyanates, demonstrates antiproliferative activity against cancer cells presumably by modulation of xenobiotic-metabolizing enzymes, such as by inhibition of cytochrome P450, and/or by induction of phase II detoxifying enzymes.{31435}
Brand:CaymanSKU:19653 -Available on backorder
Thienyldecyl isothiocyanate is an analog of thienylbutyl isothiocyanate that, like many isothiocyanates, demonstrates antiproliferative activity against cancer cells presumably by modulation of xenobiotic-metabolizing enzymes, such as by inhibition of cytochrome P450, and/or by induction of phase II detoxifying enzymes.{31435}
Brand:CaymanSKU:19653 -Available on backorder
Thienyldecyl isothiocyanate is an analog of thienylbutyl isothiocyanate that, like many isothiocyanates, demonstrates antiproliferative activity against cancer cells presumably by modulation of xenobiotic-metabolizing enzymes, such as by inhibition of cytochrome P450, and/or by induction of phase II detoxifying enzymes.{31435}
Brand:CaymanSKU:19653 -Available on backorder
thio-Miltefosine is a sulfur-containing derivative of miltefosine. Miltefosine is an inhibitor of phosphocholine cytidylyl transferase (CTP) and has antimetastatic properties.{6522,6526,6523} At concentrations of 3 and 25 µM, miltefosine inhibits proliferation of HaCaT cells (immortalized human keratinocyte cell line) by 50% and 94%, respectively.{6525} The mechanism of action of miltefosine is not well established, but the antiproliferative effect may be mediated by an increase in cellular ceramide which results in apoptosis. Treatment of cells with 25 µM miltefosine results in a 53% increase in ceramide concentration relative to control.{6525} Miltefosine is more than 90% effective in eradicating visceral infections of Leishmania species (kala azar), although the mechanism of this antiprotozoal activity is also poorly understood.{10433} The pharmacology of thio-miltefosine has not been published.
Brand:CaymanSKU:10009813 - 1 mgAvailable on backorder
thio-Miltefosine is a sulfur-containing derivative of miltefosine. Miltefosine is an inhibitor of phosphocholine cytidylyl transferase (CTP) and has antimetastatic properties.{6522,6526,6523} At concentrations of 3 and 25 µM, miltefosine inhibits proliferation of HaCaT cells (immortalized human keratinocyte cell line) by 50% and 94%, respectively.{6525} The mechanism of action of miltefosine is not well established, but the antiproliferative effect may be mediated by an increase in cellular ceramide which results in apoptosis. Treatment of cells with 25 µM miltefosine results in a 53% increase in ceramide concentration relative to control.{6525} Miltefosine is more than 90% effective in eradicating visceral infections of Leishmania species (kala azar), although the mechanism of this antiprotozoal activity is also poorly understood.{10433} The pharmacology of thio-miltefosine has not been published.
Brand:CaymanSKU:10009813 - 10 mgAvailable on backorder
thio-Miltefosine is a sulfur-containing derivative of miltefosine. Miltefosine is an inhibitor of phosphocholine cytidylyl transferase (CTP) and has antimetastatic properties.{6522,6526,6523} At concentrations of 3 and 25 µM, miltefosine inhibits proliferation of HaCaT cells (immortalized human keratinocyte cell line) by 50% and 94%, respectively.{6525} The mechanism of action of miltefosine is not well established, but the antiproliferative effect may be mediated by an increase in cellular ceramide which results in apoptosis. Treatment of cells with 25 µM miltefosine results in a 53% increase in ceramide concentration relative to control.{6525} Miltefosine is more than 90% effective in eradicating visceral infections of Leishmania species (kala azar), although the mechanism of this antiprotozoal activity is also poorly understood.{10433} The pharmacology of thio-miltefosine has not been published.
Brand:CaymanSKU:10009813 - 25 mgAvailable on backorder
thio-Miltefosine is a sulfur-containing derivative of miltefosine. Miltefosine is an inhibitor of phosphocholine cytidylyl transferase (CTP) and has antimetastatic properties.{6522,6526,6523} At concentrations of 3 and 25 µM, miltefosine inhibits proliferation of HaCaT cells (immortalized human keratinocyte cell line) by 50% and 94%, respectively.{6525} The mechanism of action of miltefosine is not well established, but the antiproliferative effect may be mediated by an increase in cellular ceramide which results in apoptosis. Treatment of cells with 25 µM miltefosine results in a 53% increase in ceramide concentration relative to control.{6525} Miltefosine is more than 90% effective in eradicating visceral infections of Leishmania species (kala azar), although the mechanism of this antiprotozoal activity is also poorly understood.{10433} The pharmacology of thio-miltefosine has not been published.
Brand:CaymanSKU:10009813 - 5 mgAvailable on backorder
Brand:CaymanSKU:- Brand:CaymanSKU:- Brand:CaymanSKU:- Brand:CaymanSKU:-
Thio-TEPA is an alkylating agent with anticancer activity (IC50 = 1.5 μM against P388 murine leukemia cells).{37276} It alkylates DNA and inhibits thymidine incorporation (IC50 = 2 μM) inducing irreversible DNA damage. Thio-TEPA crosslinks guanine nucleotides and induces cell cycle arrest via the formation of interstrand crosslinks in L1210 and MCF-7 cancer cells in vitro.{37277} In vivo, thio-TEPA reduces the number of pulmonary metastases in mice following subcutaneous injection of melanoma cells.{37278} It also decreases the number of postoperative lung metastases when administered at a dose of 10 mg/kg after surgical removal of an S-91 melanoma tumor established via intramuscular injection in mice.
Brand:CaymanSKU:23745 - 250 mgAvailable on backorder
Thio-TEPA is an alkylating agent with anticancer activity (IC50 = 1.5 μM against P388 murine leukemia cells).{37276} It alkylates DNA and inhibits thymidine incorporation (IC50 = 2 μM) inducing irreversible DNA damage. Thio-TEPA crosslinks guanine nucleotides and induces cell cycle arrest via the formation of interstrand crosslinks in L1210 and MCF-7 cancer cells in vitro.{37277} In vivo, thio-TEPA reduces the number of pulmonary metastases in mice following subcutaneous injection of melanoma cells.{37278} It also decreases the number of postoperative lung metastases when administered at a dose of 10 mg/kg after surgical removal of an S-91 melanoma tumor established via intramuscular injection in mice.
Brand:CaymanSKU:23745 - 500 mgAvailable on backorder
Brand:CaymanSKU:700871 - 1 gAvailable on backorder
Thiocarlide (isoxyl) is a thiourea derivative that was used in the 1960s to successfully treat tuberculosis (TB). It has considerable antimycobacterial activity in vitro and is effective against multi-drug resistant strains of Mycobacterium tuberculosis in the range of 1-10 µg/ml.{13370,13371} At concentrations of 10 µM, isoxyl inhibits the synthesis of M. bovis during six hours of exposure which is similar to isoniazid (INH) and ethionamide (ETH), two other predominant anti-tuberculosis drugs. Unlike INH and ETH, isoxyl also partially inhibits the synthesis of fatty acids. Isoxyl shows no acute toxicity against primary macrophage cell cultures as demonstrated by diminution of redox activity.{13371}
Brand:CaymanSKU:10006976 - 1 gAvailable on backorder
Thiocarlide (isoxyl) is a thiourea derivative that was used in the 1960s to successfully treat tuberculosis (TB). It has considerable antimycobacterial activity in vitro and is effective against multi-drug resistant strains of Mycobacterium tuberculosis in the range of 1-10 µg/ml.{13370,13371} At concentrations of 10 µM, isoxyl inhibits the synthesis of M. bovis during six hours of exposure which is similar to isoniazid (INH) and ethionamide (ETH), two other predominant anti-tuberculosis drugs. Unlike INH and ETH, isoxyl also partially inhibits the synthesis of fatty acids. Isoxyl shows no acute toxicity against primary macrophage cell cultures as demonstrated by diminution of redox activity.{13371}
Brand:CaymanSKU:10006976 - 100 mgAvailable on backorder
Thiocarlide (isoxyl) is a thiourea derivative that was used in the 1960s to successfully treat tuberculosis (TB). It has considerable antimycobacterial activity in vitro and is effective against multi-drug resistant strains of Mycobacterium tuberculosis in the range of 1-10 µg/ml.{13370,13371} At concentrations of 10 µM, isoxyl inhibits the synthesis of M. bovis during six hours of exposure which is similar to isoniazid (INH) and ethionamide (ETH), two other predominant anti-tuberculosis drugs. Unlike INH and ETH, isoxyl also partially inhibits the synthesis of fatty acids. Isoxyl shows no acute toxicity against primary macrophage cell cultures as demonstrated by diminution of redox activity.{13371}
Brand:CaymanSKU:10006976 - 50 mgAvailable on backorder
Thiocarlide (isoxyl) is a thiourea derivative that was used in the 1960s to successfully treat tuberculosis (TB). It has considerable antimycobacterial activity in vitro and is effective against multi-drug resistant strains of Mycobacterium tuberculosis in the range of 1-10 µg/ml.{13370,13371} At concentrations of 10 µM, isoxyl inhibits the synthesis of M. bovis during six hours of exposure which is similar to isoniazid (INH) and ethionamide (ETH), two other predominant anti-tuberculosis drugs. Unlike INH and ETH, isoxyl also partially inhibits the synthesis of fatty acids. Isoxyl shows no acute toxicity against primary macrophage cell cultures as demonstrated by diminution of redox activity.{13371}
Brand:CaymanSKU:10006976 - 500 mgAvailable on backorder
Thiocillin I is an antibiotic originally isolated from Bacillus that has activity against Gram-positive, but not Gram-negative, bacteria.{49021} It inhibits the growth of B. subtilis, B. anthracis, S. aureus, S. pyogenes, and S. pneumoniae strains in vitro (MICs = 0.2-3.13 μg/ml). Thiocillin I exhibits antibiotic activity in a mouse model of S. pyogenes infection (ED50 = 2.91 mg/kg).
Brand:CaymanSKU:26681 - 2.5 mgAvailable on backorder
Thiocillin I is an antibiotic originally isolated from Bacillus that has activity against Gram-positive, but not Gram-negative, bacteria.{49021} It inhibits the growth of B. subtilis, B. anthracis, S. aureus, S. pyogenes, and S. pneumoniae strains in vitro (MICs = 0.2-3.13 μg/ml). Thiocillin I exhibits antibiotic activity in a mouse model of S. pyogenes infection (ED50 = 2.91 mg/kg).
Brand:CaymanSKU:26681 - 500 µgAvailable on backorder
Thiocolchicine is an inhibitor of microtubule assembly (IC50 = 2.5 µM) and a derivative of colchicine (Item No. 9000760).{36788} It inhibits binding of colchicine to tubulin (Ki = 0.7 µM in a radioligand binding assay). Thiocolchicine inhibits proliferation of MDA-MB-231 and multidrug resistant (MDR) MCF-7 ADRr breast cancer cells (IC50s = 0.6 and 400 nM, respectively) as well MDR CEM-VBL leukemia cells (IC50 = 50 nM).{36789}
Brand:CaymanSKU:-Available on backorder
Thiocolchicine is an inhibitor of microtubule assembly (IC50 = 2.5 µM) and a derivative of colchicine (Item No. 9000760).{36788} It inhibits binding of colchicine to tubulin (Ki = 0.7 µM in a radioligand binding assay). Thiocolchicine inhibits proliferation of MDA-MB-231 and multidrug resistant (MDR) MCF-7 ADRr breast cancer cells (IC50s = 0.6 and 400 nM, respectively) as well MDR CEM-VBL leukemia cells (IC50 = 50 nM).{36789}
Brand:CaymanSKU:-Available on backorder
Thiocolchicine is an inhibitor of microtubule assembly (IC50 = 2.5 µM) and a derivative of colchicine (Item No. 9000760).{36788} It inhibits binding of colchicine to tubulin (Ki = 0.7 µM in a radioligand binding assay). Thiocolchicine inhibits proliferation of MDA-MB-231 and multidrug resistant (MDR) MCF-7 ADRr breast cancer cells (IC50s = 0.6 and 400 nM, respectively) as well MDR CEM-VBL leukemia cells (IC50 = 50 nM).{36789}
Brand:CaymanSKU:-Available on backorder
Thiocolchicine is an inhibitor of microtubule assembly (IC50 = 2.5 µM) and a derivative of colchicine (Item No. 9000760).{36788} It inhibits binding of colchicine to tubulin (Ki = 0.7 µM in a radioligand binding assay). Thiocolchicine inhibits proliferation of MDA-MB-231 and multidrug resistant (MDR) MCF-7 ADRr breast cancer cells (IC50s = 0.6 and 400 nM, respectively) as well MDR CEM-VBL leukemia cells (IC50 = 50 nM).{36789}
Brand:CaymanSKU:-Available on backorder
Thiocoraline is a depsipeptide and DNA bis-intercalator originally isolated from Micromonospora with antibacterial and anticancer activities.{53564,53565} It is active against the Gram-positive bacteria S. aureus, B. subtilis, and M. luteus (MICs = 0.05, 0.05, and 0.03 µg/ml, respectively) but not Gram-negative E. coli, K. pneumoniae, or P. aeruginosa (MICs = >100 µg/ml for all).{53564} Thiocoraline inhibits RNA and DNA polymerase and thymidylate synthase (IC50s = 6, 6, and 15 µg/ml, respectively), as well as RNA and DNA synthesis in vitro (IC50s = 0.008 and 0.4 µg/ml, respectively). It is cytotoxic to P388, A549, HT-29, and MEL-28 cancer cells (IC50s = 0.002, 0.002, 0.01, and 0.002 µg/ml, respectively).
Brand:CaymanSKU:29509 - 1 mgAvailable on backorder
Galectins are a family of glycan-binding lectins with diverse regulatory roles in physiological processes.{29013,29018} They have significant roles in inflammation and cancer.{29013,29018} Thiodigalactoside is a diglycan that binds galectins-1, -3, -8, and -9 with Kd values between 24 and 78 µM.{29017,29019} It is used to investigate the roles of these galectins in cell signaling and carcinogenesis.{29014,29015,29016}
Brand:CaymanSKU:-Out of stock
Galectins are a family of glycan-binding lectins with diverse regulatory roles in physiological processes.{29013,29018} They have significant roles in inflammation and cancer.{29013,29018} Thiodigalactoside is a diglycan that binds galectins-1, -3, -8, and -9 with Kd values between 24 and 78 µM.{29017,29019} It is used to investigate the roles of these galectins in cell signaling and carcinogenesis.{29014,29015,29016}
Brand:CaymanSKU:-Out of stock
Galectins are a family of glycan-binding lectins with diverse regulatory roles in physiological processes.{29013,29018} They have significant roles in inflammation and cancer.{29013,29018} Thiodigalactoside is a diglycan that binds galectins-1, -3, -8, and -9 with Kd values between 24 and 78 µM.{29017,29019} It is used to investigate the roles of these galectins in cell signaling and carcinogenesis.{29014,29015,29016}
Brand:CaymanSKU:-Out of stock
Galectins are a family of glycan-binding lectins with diverse regulatory roles in physiological processes.{29013,29018} They have significant roles in inflammation and cancer.{29013,29018} Thiodigalactoside is a diglycan that binds galectins-1, -3, -8, and -9 with Kd values between 24 and 78 µM.{29017,29019} It is used to investigate the roles of these galectins in cell signaling and carcinogenesis.{29014,29015,29016}
Brand:CaymanSKU:-Out of stock
Thiodiglycolic acid-d4 (TDGA-d4) contains four deuterium atoms at the 2, 2, 2’, and 2’ positions. It is intended for use as an internal standard for the quantification of TDGA by GC- or LC-mass spectrometry. TDGA is a product of interaction of the cysteine component of glutathione with two-carbon units released during catabolism. It is found in concentrations below 20 mg/l in urine of healthy individuals and elevated following ingestion of certain drugs.{30000} Determination of TDGA concentration in urine has been used to characterize the metabolism of substances participating in methionine synthesis in order to identify imbalances leading to hyperhomocystinuria.{29999} Additionally, because TDGA is used as raw material in the polymer industry, its detection in human urine has served as a biomarker for exposure to carcinogenic vapors such as vinylchloride monomer produced during polymer manufacture.{29999}
Brand:CaymanSKU:9002478 - 1 mgAvailable on backorder
Thiodiglycolic acid-d4 (TDGA-d4) contains four deuterium atoms at the 2, 2, 2’, and 2’ positions. It is intended for use as an internal standard for the quantification of TDGA by GC- or LC-mass spectrometry. TDGA is a product of interaction of the cysteine component of glutathione with two-carbon units released during catabolism. It is found in concentrations below 20 mg/l in urine of healthy individuals and elevated following ingestion of certain drugs.{30000} Determination of TDGA concentration in urine has been used to characterize the metabolism of substances participating in methionine synthesis in order to identify imbalances leading to hyperhomocystinuria.{29999} Additionally, because TDGA is used as raw material in the polymer industry, its detection in human urine has served as a biomarker for exposure to carcinogenic vapors such as vinylchloride monomer produced during polymer manufacture.{29999}
Brand:CaymanSKU:9002478 - 5 mgAvailable on backorder
Thiodiglycolic acid-d4 (TDGA-d4) contains four deuterium atoms at the 2, 2, 2’, and 2’ positions. It is intended for use as an internal standard for the quantification of TDGA by GC- or LC-mass spectrometry. TDGA is a product of interaction of the cysteine component of glutathione with two-carbon units released during catabolism. It is found in concentrations below 20 mg/l in urine of healthy individuals and elevated following ingestion of certain drugs.{30000} Determination of TDGA concentration in urine has been used to characterize the metabolism of substances participating in methionine synthesis in order to identify imbalances leading to hyperhomocystinuria.{29999} Additionally, because TDGA is used as raw material in the polymer industry, its detection in human urine has served as a biomarker for exposure to carcinogenic vapors such as vinylchloride monomer produced during polymer manufacture.{29999}
Brand:CaymanSKU:9002478 - 500 µgAvailable on backorder
Thioetheramide-PC is a structurally modified phospholipid that functions as a competitive, reversible inhibitor of secretory phospholipase A2 (sPLA2).{808,2624} The IC50 value for thioetheramide-PC is 2 µM at a substrate concentration of 0.5 mM.{808} In addition to binding to the catalytic site of sPLA2, thioetheramide-PC also binds to the activator site of this enzyme. The binding of thioetheramide-PC to the activator site is tighter than its binding to the catalytic site. The result of this dual interaction is that at low concentrations thioetheramide-PC may activate phospholipase activity rather than inhibiting it.{808}
Brand:CaymanSKU:62750 - 10 mgAvailable on backorder
Thioetheramide-PC is a structurally modified phospholipid that functions as a competitive, reversible inhibitor of secretory phospholipase A2 (sPLA2).{808,2624} The IC50 value for thioetheramide-PC is 2 µM at a substrate concentration of 0.5 mM.{808} In addition to binding to the catalytic site of sPLA2, thioetheramide-PC also binds to the activator site of this enzyme. The binding of thioetheramide-PC to the activator site is tighter than its binding to the catalytic site. The result of this dual interaction is that at low concentrations thioetheramide-PC may activate phospholipase activity rather than inhibiting it.{808}
Brand:CaymanSKU:62750 - 25 mgAvailable on backorder
Thioetheramide-PC is a structurally modified phospholipid that functions as a competitive, reversible inhibitor of secretory phospholipase A2 (sPLA2).{808,2624} The IC50 value for thioetheramide-PC is 2 µM at a substrate concentration of 0.5 mM.{808} In addition to binding to the catalytic site of sPLA2, thioetheramide-PC also binds to the activator site of this enzyme. The binding of thioetheramide-PC to the activator site is tighter than its binding to the catalytic site. The result of this dual interaction is that at low concentrations thioetheramide-PC may activate phospholipase activity rather than inhibiting it.{808}
Brand:CaymanSKU:62750 - 5 mgAvailable on backorder
The rapid, selective, and sensitive sensing of thiols is important in diverse areas of research. This thiofluor 623 responds upon exposure to thiols with an increase in fluorescence intensity of up to 120-fold.{16211} The response is selective for thiols and occurs in aqueous media.{16211} In the absence of thiols, the probe is essentially non-fluorescent; thiols cause cleavage of the probe, generating a fluorophore with an absorption maximum of 563 nm and emission at 623 nm.{16211} The fluorescence quantum yield of the cleaved product, generated in response to thiols, increases in more viscous media, suggesting ideal performance in biological systems and applicability to single-molecule or 2-photon sensing schemes. The thiofluor 623 is cell-permeable and reacts selectively with intracellular thiols.{16211} The pseudo-first order rate constant (kobs) depends on substrate (e.g., 2.1 x 10−3 s−1 for cysteine, 2.0 x 10−5 s−1 for human serum albumin).{16211}
Brand:CaymanSKU:- The rapid, selective, and sensitive sensing of thiols is important in diverse areas of research. This thiofluor 623 responds upon exposure to thiols with an increase in fluorescence intensity of up to 120-fold.{16211} The response is selective for thiols and occurs in aqueous media.{16211} In the absence of thiols, the probe is essentially non-fluorescent; thiols cause cleavage of the probe, generating a fluorophore with an absorption maximum of 563 nm and emission at 623 nm.{16211} The fluorescence quantum yield of the cleaved product, generated in response to thiols, increases in more viscous media, suggesting ideal performance in biological systems and applicability to single-molecule or 2-photon sensing schemes. The thiofluor 623 is cell-permeable and reacts selectively with intracellular thiols.{16211} The pseudo-first order rate constant (kobs) depends on substrate (e.g., 2.1 x 10−3 s−1 for cysteine, 2.0 x 10−5 s−1 for human serum albumin).{16211}
Brand:CaymanSKU:- The rapid, selective, and sensitive sensing of thiols is important in diverse areas of research. This thiofluor 623 responds upon exposure to thiols with an increase in fluorescence intensity of up to 120-fold.{16211} The response is selective for thiols and occurs in aqueous media.{16211} In the absence of thiols, the probe is essentially non-fluorescent; thiols cause cleavage of the probe, generating a fluorophore with an absorption maximum of 563 nm and emission at 623 nm.{16211} The fluorescence quantum yield of the cleaved product, generated in response to thiols, increases in more viscous media, suggesting ideal performance in biological systems and applicability to single-molecule or 2-photon sensing schemes. The thiofluor 623 is cell-permeable and reacts selectively with intracellular thiols.{16211} The pseudo-first order rate constant (kobs) depends on substrate (e.g., 2.1 x 10−3 s−1 for cysteine, 2.0 x 10−5 s−1 for human serum albumin).{16211}
Brand:CaymanSKU:-
ThioGlo1 is a thiol-reactive fluorescent probe.{52416,52417,52418} Upon reaction with a thiol group, a fluorescent adduct is formed that displays excitation/emission maxima of 384/513 nm, respectively.{52417,52418} It also reacts with sulfite to form a fluorescent adduct with similar spectral characteristics, and interference from sulfite during thiol determination must be accounted for using secondary methods. ThioGlo1 has been used to monitor the oxidative stability of beer.
Brand:CaymanSKU:- ThioGlo1 is a thiol-reactive fluorescent probe.{52416,52417,52418} Upon reaction with a thiol group, a fluorescent adduct is formed that displays excitation/emission maxima of 384/513 nm, respectively.{52417,52418} It also reacts with sulfite to form a fluorescent adduct with similar spectral characteristics, and interference from sulfite during thiol determination must be accounted for using secondary methods. ThioGlo1 has been used to monitor the oxidative stability of beer.
Brand:CaymanSKU:- ThioGlo1 is a thiol-reactive fluorescent probe.{52416,52417,52418} Upon reaction with a thiol group, a fluorescent adduct is formed that displays excitation/emission maxima of 384/513 nm, respectively.{52417,52418} It also reacts with sulfite to form a fluorescent adduct with similar spectral characteristics, and interference from sulfite during thiol determination must be accounted for using secondary methods. ThioGlo1 has been used to monitor the oxidative stability of beer.
Brand:CaymanSKU:- ThioGlo1 is a thiol-reactive fluorescent probe.{52416,52417,52418} Upon reaction with a thiol group, a fluorescent adduct is formed that displays excitation/emission maxima of 384/513 nm, respectively.{52417,52418} It also reacts with sulfite to form a fluorescent adduct with similar spectral characteristics, and interference from sulfite during thiol determination must be accounted for using secondary methods. ThioGlo1 has been used to monitor the oxidative stability of beer.
Brand:CaymanSKU:- Brand:CaymanSKU:700341 - 1 eaAvailable on backorder
The detection and measurement of free thiols (i.e., free cysteine, glutathione, and cysteine residues on proteins) is one of the essential tasks for investigating biological processes and events in many biological systems. Cayman’s Thiol Detection Assay Kit provides a simple, reproducible, and sensitive tool for assaying free thiol content in samples (i.e., plasma, serum, tissue homogenates, cell lysates, and urine). The assay utilizes a proprietary fluorometric detector that reacts with thiol groups to emit a strong fluorescent signal which can be detected using excitation wavelengths between 380-390 nm and emission wavelengths between 510-520 nm.
Brand:CaymanSKU:700340 - 480 wellsAvailable on backorder
The detection and measurement of free thiols (i.e., free cysteine, glutathione, and cysteine residues on proteins) is one of the essential tasks for investigating biological processes and events in many biological systems. Cayman’s Thiol Detection Assay Kit provides a simple, reproducible, and sensitive tool for assaying free thiol content in samples (i.e., plasma, serum, tissue homogenates, cell lysates, and urine). The assay utilizes a proprietary fluorometric detector that reacts with thiol groups to emit a strong fluorescent signal which can be detected using excitation wavelengths between 380-390 nm and emission wavelengths between 510-520 nm.
Brand:CaymanSKU:700340 - 96 wellsAvailable on backorder
Thiolutin is a natural dithiol that reversibly inhibits bacterial and yeast RNA polymerases (IC50 = 3 μg/ml).{20586,20588,20587} Because of this, it can be used for the analysis of mRNA stability. Thiolutin also inhibits endothelial cell adhesion (IC50 induced angiogenesis in mice by inhibiting Hsp27 interactions with cytoskeletal elements.{20584,20585}
Brand:CaymanSKU:11350 - 1 mgAvailable on backorder
Thiolutin is a natural dithiol that reversibly inhibits bacterial and yeast RNA polymerases (IC50 = 3 μg/ml).{20586,20588,20587} Because of this, it can be used for the analysis of mRNA stability. Thiolutin also inhibits endothelial cell adhesion (IC50 induced angiogenesis in mice by inhibiting Hsp27 interactions with cytoskeletal elements.{20584,20585}
Brand:CaymanSKU:11350 - 10 mgAvailable on backorder
Thiolutin is a natural dithiol that reversibly inhibits bacterial and yeast RNA polymerases (IC50 = 3 μg/ml).{20586,20588,20587} Because of this, it can be used for the analysis of mRNA stability. Thiolutin also inhibits endothelial cell adhesion (IC50 induced angiogenesis in mice by inhibiting Hsp27 interactions with cytoskeletal elements.{20584,20585}
Brand:CaymanSKU:11350 - 5 mgAvailable on backorder
Thiomuscimol is a GABAA receptor agonist (IC50 = 19 nM).{23065,30583} It has been used as a photoaffinity label for the purification and identification of GABA binding sites within the GABAA receptor complex.{30584}
Brand:CaymanSKU:-Available on backorder
Thiomuscimol is a GABAA receptor agonist (IC50 = 19 nM).{23065,30583} It has been used as a photoaffinity label for the purification and identification of GABA binding sites within the GABAA receptor complex.{30584}
Brand:CaymanSKU:-Available on backorder
Thiomuscimol is a GABAA receptor agonist (IC50 = 19 nM).{23065,30583} It has been used as a photoaffinity label for the purification and identification of GABA binding sites within the GABAA receptor complex.{30584}
Brand:CaymanSKU:-Available on backorder
Thiomuscimol is a GABAA receptor agonist (IC50 = 19 nM).{23065,30583} It has been used as a photoaffinity label for the purification and identification of GABA binding sites within the GABAA receptor complex.{30584}
Brand:CaymanSKU:-Available on backorder
Thioperamide (maleate) is a selective histamine H3 receptor antagonist that crosses the blood-brain barrier. This compound binds to rat cerebral cortical cells in vitro with a pKi value of 8.4 and inhibits histamine binding in vivo with an ED50 value of 1 mg/kg.{16957} At a dose of 5 mg/kg thioperamide (maleate) inhibits kindled seizures in rats by decreasing histamine and gamma-aminobutyric acid.{16495}
Brand:CaymanSKU:10011127 - 1 mgAvailable on backorder
Thioperamide (maleate) is a selective histamine H3 receptor antagonist that crosses the blood-brain barrier. This compound binds to rat cerebral cortical cells in vitro with a pKi value of 8.4 and inhibits histamine binding in vivo with an ED50 value of 1 mg/kg.{16957} At a dose of 5 mg/kg thioperamide (maleate) inhibits kindled seizures in rats by decreasing histamine and gamma-aminobutyric acid.{16495}
Brand:CaymanSKU:10011127 - 10 mgAvailable on backorder
Thioperamide (maleate) is a selective histamine H3 receptor antagonist that crosses the blood-brain barrier. This compound binds to rat cerebral cortical cells in vitro with a pKi value of 8.4 and inhibits histamine binding in vivo with an ED50 value of 1 mg/kg.{16957} At a dose of 5 mg/kg thioperamide (maleate) inhibits kindled seizures in rats by decreasing histamine and gamma-aminobutyric acid.{16495}
Brand:CaymanSKU:10011127 - 25 mgAvailable on backorder
Thioperamide (maleate) is a selective histamine H3 receptor antagonist that crosses the blood-brain barrier. This compound binds to rat cerebral cortical cells in vitro with a pKi value of 8.4 and inhibits histamine binding in vivo with an ED50 value of 1 mg/kg.{16957} At a dose of 5 mg/kg thioperamide (maleate) inhibits kindled seizures in rats by decreasing histamine and gamma-aminobutyric acid.{16495}
Brand:CaymanSKU:10011127 - 5 mgAvailable on backorder
Brand:CaymanSKU:11061 - 1 gAvailable on backorder
Brand:CaymanSKU:11061 - 5 gAvailable on backorder
Brand:CaymanSKU:11061 - 500 mgAvailable on backorder
Thiopropamine is an analog of amphetamine in which the phenyl ring has been replaced by a thiophene group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:9002037 - 1 mgAvailable on backorder
Thiopropamine is an analog of amphetamine in which the phenyl ring has been replaced by a thiophene group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:9002037 - 10 mgAvailable on backorder
Thiopropamine is an analog of amphetamine in which the phenyl ring has been replaced by a thiophene group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:9002037 - 5 mgAvailable on backorder
Immunogen: Human Trx1 • Host: Mouse • Species Reactivity: (+) Human • Applications: ELISA, IF, IP, WB
Brand:CaymanSKU:11539- 1 eaAvailable on backorder
Immunogen: Human Trx1 • Host: Mouse • Species Reactivity: (+) Human • Applications: ELISA, IF, IP, WB
Brand:CaymanSKU:11539- 1 ea Thioredoxin 1 (Trx1) is a thiol-disulfide oxidoreductase and part of the antioxidant thioredoxin system that is involved in the maintenance of cellular thiol redox homeostasis.{57135,57136,57138} It is ubiquitously expressed, localizes primarily to the cytoplasm with some nuclear localization, and is upregulated in and released from cells under conditions of oxidative stress.{57135,57136,57137} Trx1 contains two active site cysteine residues at positions 32 and 35, with additional cysteines at positions 62, 69, and 73.{57136} During the catalytic cycle, the active site cysteines are oxidized to a disulfide upon reduction of oxidized protein disulfide substrates and are subsequently restored to their reduced state by thioredoxin reductase (TrxR) and NADPH.{57135,57136} It regulates redox-sensitive transcription factors including NF-κB, p53, and the glucocorticoid receptor, as well as inhibits apoptosis through redox-sensitive binding and regulation of apoptosis signal-regulating kinase 1 (ASK1).{57136,57137} Exogenous administration of extracellular recombinant human Trx1 has anti-inflammatory effects in a variety of animal models.{57136} Trx1 levels are increased in a variety of human primary tumors, and increased tumor levels of Trx1 are associated with decreased survival in patients with colorectal cancer.{57137} Cayman’s Thioredoxin 1 (human) Monoclonal Antibody (Clone 2G11) can be used for ELISA, immunofluorescence (IF), immunoprecipitation (IP), and Western blot (WB) applications.
Brand:CaymanSKU:11539 - 1 eaAvailable on backorder
Immunogen: Recombinant human Trx1 • Host: Goat • Species Reactivity: (+) Human • Applications: ELISA, IHC, WB
Brand:CaymanSKU:11541- 1 eaAvailable on backorder
Immunogen: Recombinant human Trx1 • Host: Goat • Species Reactivity: (+) Human • Applications: ELISA, IHC, WB
Brand:CaymanSKU:11541- 1 ea Thioredoxin 1 (Trx1) is a thiol-disulfide oxidoreductase and part of the antioxidant thioredoxin system that is involved in the maintenance of cellular thiol redox homeostasis.{57135,57136,57138} It is ubiquitously expressed, localizes primarily to the cytoplasm with some nuclear localization, and is upregulated in and released from cells under conditions of oxidative stress.{57135,57137,57136} Trx1 contains two active site cysteine residues at positions 32 and 35, with additional cysteines at positions 62, 69, and 73.{57136} During the catalytic cycle, the active site cysteines are oxidized to a disulfide upon reduction of oxidized protein disulfide substrates and are subsequently restored to their reduced state by thioredoxin reductase (TrxR) and NADPH.{57135,57136} It regulates redox-sensitive transcription factors including NF-κB, p53, and the glucocorticoid receptor, as well as inhibits apoptosis through redox-sensitive binding and regulation of apoptosis signal-regulating kinase 1 (ASK1).{57137,57136} Exogenous administration of extracellular recombinant human Trx1 has anti-inflammatory effects in a variety of animal models.{57136} Trx1 levels are increased in a variety of human primary tumors, and increased tumor levels of Trx1 are associated with decreased survival in patients with colorectal cancer.{57137} Cayman’s Thioredoxin 1 (human) Polyclonal Antibody can be used for ELISA, immunohistochemistry (IHC), and Western blot (WB) applications.
Brand:CaymanSKU:11541 - 1 eaAvailable on backorder
Immunogen: Synthetic peptide from human Trx1, amino acids 84-105 • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) Full length thioredoxin 1; (-) Trx80 • Applications: ELISA, IHC, WB • MW = 12 kDa
Brand:CaymanSKU:11542- 1 eaAvailable on backorder
Immunogen: Synthetic peptide from human Trx1, amino acids 84-105 • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) Full length thioredoxin 1; (-) Trx80 • Applications: ELISA, IHC, WB • MW = 12 kDa
Brand:CaymanSKU:11542- 1 ea Thioredoxin 1 (Trx1) is a thiol-disulfide oxidoreductase and part of the antioxidant thioredoxin system that is involved in the maintenance of cellular thiol redox homeostasis.{57135,57136,57138} It is ubiquitously expressed, localizes primarily to the cytoplasm with some nuclear localization, and is upregulated in and released from cells under conditions of oxidative stress.{57135,57136,57137} Trx1 contains two active site cysteine residues at positions 32 and 35, with additional cysteines at positions 62, 69, and 73.{57136} During the catalytic cycle, the active site cysteines are oxidized to a disulfide upon reduction of oxidized protein disulfide substrates and are subsequently restored to their reduced state by thioredoxin reductase (TrxR) and NADPH.{57135,57136} It regulates redox-sensitive transcription factors including NF-κB, p53, and the glucocorticoid receptor, as well as inhibits apoptosis through redox-sensitive binding and regulation of apoptosis signal-regulating kinase 1 (ASK1).{57136,57137} Exogenous administration of extracellular recombinant human Trx1 has anti-inflammatory effects in a variety of animal models.{57136} Trx1 levels are increased in a variety of human primary tumors, and increased tumor levels of Trx1 are associated with decreased survival in patients with colorectal cancer.{57137} Cayman’s Thioredoxin 1 (human) Polyclonal Antibody (aa 84-105) can be used for ELISA, immunohistochemistry (IHC), and Western blot (WB) applications. The antibody recognizes Trx1 at 12 kDa from human samples.
Brand:CaymanSKU:11542 - 1 eaAvailable on backorder
Immunogen: Human Trx1 • Host: Goat • Species Reactivity: (+) Human • Applications: IHC, WB • MW = 12 kDa
Brand:CaymanSKU:11538- 1 eaAvailable on backorder
Immunogen: Human Trx1 • Host: Goat • Species Reactivity: (+) Human • Applications: IHC, WB • MW = 12 kDa
Brand:CaymanSKU:11538- 1 ea Thioredoxin 1 (Trx1) is a thiol-disulfide oxidoreductase and part of the antioxidant thioredoxin system that is involved in the maintenance of cellular thiol redox homeostasis.{57135,57136,57138} It is ubiquitously expressed, localizes primarily to the cytoplasm with some nuclear localization, and is upregulated in and released from cells under conditions of oxidative stress.{57135,57137,57136} Trx1 contains two active site cysteine residues at positions 32 and 35, with additional cysteines at positions 62, 69, and 73.{57136} During the catalytic cycle, the active site cysteines are oxidized to a disulfide upon reduction of oxidized protein disulfide substrates and are subsequently restored to their reduced state by thioredoxin reductase (TrxR) and NADPH.{57135,57136} It regulates redox-sensitive transcription factors including NF-κB, p53, and the glucocorticoid receptor, as well as inhibits apoptosis through redox-sensitive binding and regulation of apoptosis signal-regulating kinase 1 (ASK1).{57137,57136} Exogenous administration of extracellular recombinant human Trx1 has anti-inflammatory effects in a variety of animal models.{57136} Trx1 levels are increased in a variety of human primary tumors, and increased tumor levels of Trx1 are associated with decreased survival in patients with colorectal cancer.{57137} Cayman’s Thioredoxin 1 (human) Pure Polyclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes Trx1 at 12 kDa from human samples.
Brand:CaymanSKU:11538 - 1 eaAvailable on backorder
Brand:CaymanSKU:11540- 1 eaAvailable on backorder
Brand:CaymanSKU:11540- 1 ea Thioredoxin 1 (Trx1) is a thiol-disulfide oxidoreductase and part of the antioxidant thioredoxin system that is involved in the maintenance of cellular thiol redox homeostasis.{57135,57136,57138} It is ubiquitously expressed, localizes primarily to the cytoplasm with some nuclear localization, and is upregulated in and released from cells under conditions of oxidative stress.{57135,57137,57136} Trx1 contains two active site cysteine residues at positions 32 and 35, with additional cysteines at positions 62, 69, and 73.{57136} During the catalytic cycle, the active site cysteines are oxidized to a disulfide upon reduction of oxidized protein disulfide substrates and are subsequently restored to their reduced state by thioredoxin reductase (TrxR) and NADPH.{57135,57136} It regulates redox-sensitive transcription factors including NF-κB, p53, and the glucocorticoid receptor, as well as inhibits apoptosis through redox-sensitive binding and regulation of apoptosis signal-regulating kinase 1 (ASK1).{57137,57136} Homozygous disruption of the gene encoding Trx1, Txn1, is embryonic lethal in mice.{52683,57135} Cayman’s Thioredoxin 1 (mouse) Polyclonal Antibody can be used for Western blot (WB) applications.
Brand:CaymanSKU:11540 - 1 eaAvailable on backorder
Immunogen: N-terminal 80 amino acids of human Trx1 • Host: Mouse • Species Reactivity: (+) Human • Applications: ELISA, IF, IP, WB • MW = 12 and 9 kDa for Trx1 and Trx80, respectively
Brand:CaymanSKU:11543- 1 eaAvailable on backorder
Immunogen: N-terminal 80 amino acids of human Trx1 • Host: Mouse • Species Reactivity: (+) Human • Applications: ELISA, IF, IP, WB • MW = 12 and 9 kDa for Trx1 and Trx80, respectively
Brand:CaymanSKU:11543- 1 ea