Cayman
Showing 39751–39900 of 45550 results
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sn-glycero-3-Phosphocholine (sn-glycero-3-PC) is a nootropic phospholipid, a precursor to choline biosynthesis, and an intermediate in the metabolism of phosphatidylcholine.{32447} In vivo, sn-glycero-3-PC is converted to phosphorylcholine, a metabolically active form of choline that increases acetylcholine synthesis and release in rat hippocampus. It prevents scopolamine-induced amnesia in a passive avoidance test in rats and exerts neuroprotective effects in models of altered cholinergic neurotransmission and models of brain vascular injury.{32447,45044}
Brand:CaymanSKU:20736 -Available on backorder
sn-glycero-3-Phosphocholine (sn-glycero-3-PC) is a nootropic phospholipid, a precursor to choline biosynthesis, and an intermediate in the metabolism of phosphatidylcholine.{32447} In vivo, sn-glycero-3-PC is converted to phosphorylcholine, a metabolically active form of choline that increases acetylcholine synthesis and release in rat hippocampus. It prevents scopolamine-induced amnesia in a passive avoidance test in rats and exerts neuroprotective effects in models of altered cholinergic neurotransmission and models of brain vascular injury.{32447,45044}
Brand:CaymanSKU:20736 -Available on backorder
sn-glycero-3-Phosphocholine (sn-glycero-3-PC) is a nootropic phospholipid, a precursor to choline biosynthesis, and an intermediate in the metabolism of phosphatidylcholine.{32447} In vivo, sn-glycero-3-PC is converted to phosphorylcholine, a metabolically active form of choline that increases acetylcholine synthesis and release in rat hippocampus. It prevents scopolamine-induced amnesia in a passive avoidance test in rats and exerts neuroprotective effects in models of altered cholinergic neurotransmission and models of brain vascular injury.{32447,45044}
Brand:CaymanSKU:20736 -Available on backorder
Brand:CaymanSKU:32861 - 100 µlAvailable on backorder
Brand:CaymanSKU:32861- 100 µlAvailable on backorder
Brand:CaymanSKU:32861- 100 µl
Brand:CaymanSKU:32862 - 100 µlAvailable on backorder
Brand:CaymanSKU:32862- 100 µlAvailable on backorder
Brand:CaymanSKU:32862- 100 µl
SNAP is an S-nitrosothiol which serves as a NO donor and a potent vasodilator. Its stability in solution varies from seconds to hours depending on temperature, buffer composition and metal content.{5064,4274,3632,1285} At pH 6-8 and 37°C, the half-life of SNAP is approximately six hours in the presence of transition metal ion chelators.{3055,1285}
Brand:CaymanSKU:82250 - 10 mgAvailable on backorder
SNAP is an S-nitrosothiol which serves as a NO donor and a potent vasodilator. Its stability in solution varies from seconds to hours depending on temperature, buffer composition and metal content.{5064,4274,3632,1285} At pH 6-8 and 37°C, the half-life of SNAP is approximately six hours in the presence of transition metal ion chelators.{3055,1285}
Brand:CaymanSKU:82250 - 100 mgAvailable on backorder
SNAP is an S-nitrosothiol which serves as a NO donor and a potent vasodilator. Its stability in solution varies from seconds to hours depending on temperature, buffer composition and metal content.{5064,4274,3632,1285} At pH 6-8 and 37°C, the half-life of SNAP is approximately six hours in the presence of transition metal ion chelators.{3055,1285}
Brand:CaymanSKU:82250 - 25 mgAvailable on backorder
SNAP is an S-nitrosothiol which serves as a NO donor and a potent vasodilator. Its stability in solution varies from seconds to hours depending on temperature, buffer composition and metal content.{5064,4274,3632,1285} At pH 6-8 and 37°C, the half-life of SNAP is approximately six hours in the presence of transition metal ion chelators.{3055,1285}
Brand:CaymanSKU:82250 - 50 mgAvailable on backorder
Immunogen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser187 of rat SNAP-25 • Host: Rabbit • Species Reactivity: (+) Mouse, Rat • Applications: WB • MW = ~25 kDa
Brand:CaymanSKU:29294- 100 µl Synaptosomal-associated protein 25 (SNAP-25) is a member of the SNARE complex, which also includes syntaxin and VAMP, that is responsible for fusing synaptic vesicles with the presynaptic plasma membrane to facilitate neurotransmitter release.{55160} Two SNAP-25 isoforms, SNAP-25a and SNAP-25b, are generated through alternative splicing, with SNAP-25b expressed only during the postnatal period and as the predominant isoform in the brain.{55161} SNAP-25 contains two α helices, as well as one large and several smaller intrinsically disordered domains.{55160} SNAP-25 is located primarily on the intracellular side of the presynaptic plasma membrane in neurons and interacts with a variety of proteins to orchestrate vesicle fusion in a calcium-triggered manner and to mediate spine development.{55160} It is also found in the pancreas, enteroendocrine cells, and the chromaffin cells of the adrenal medulla where it is involved in hormone secretion.{55161} SNAP-25 can be phosphorylated at serine 187 (Ser187) in a neuronal activity-dependent manner by PKC, a modification that increases the rate of synaptic vesicle recruitment and is essential for SNAP-25b inhibition of voltage-gated calcium channels (VGCCs) and incorporation of NMDA receptors into the postsynaptic membrane.{55154,55155,55156} Phosphorylation at Ser187 also facilitates neurotransmitter release and inhibits presynaptic short-term plasticity via regulation of synaptic vesicle dynamics.{55157} A point mutation at Ser187 (S187A) induces anxiety-like behavior in mice homozygous for the mutation and induces working memory deficits and an immature phenotype in hippocampal dental granule cells of adult mice heterozygous for the mutation.{55158,55159} Cayman’s SNAP-25 (Phospho-Ser187) Polyclonal Antibody can be used for Western blot (WB) applications. The antibody recognizes SNAP-25 (phospho-Ser187) at approximately 25 kDa from mouse and rat samples.
Brand:CaymanSKU:29294 - 100 µlAvailable on backorder
Immunogen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser187 of rat SNAP-25 • Host: Rabbit • Species Reactivity: (+) Mouse, Rat • Applications: WB • MW = ~25 kDa
Brand:CaymanSKU:29294- 100 µlAvailable on backorder
Brand:CaymanSKU:29293- 100 µl Synaptosomal-associated protein 25 (SNAP-25) is a member of the SNARE complex, which also includes syntaxin and VAMP, that is responsible for fusing synaptic vesicles with the presynaptic plasma membrane to facilitate neurotransmitter release.{55160} Two SNAP-25 isoforms, SNAP-25a and SNAP-25b, are generated through alternative splicing, with SNAP-25b expressed only during the postnatal period and as the predominant isoform in the brain.{55161} SNAP-25 contains two α helices, as well as one large and several smaller intrinsically disordered domains.{55160} It also contains a cluster of closely spaced cysteine residues that are subject to palmitoylation, a modification that regulates the intracellular distribution of SNAP-25, as well as residues subject to phosphorylation, modifications that modulate the rate of vesicle recruitment and its interactions with syntaxin.{55160,55154,55211} SNAP-25 is located primarily on the intracellular side of the presynaptic plasma membrane in neurons and interacts with a variety of proteins to orchestrate vesicle fusion in a calcium-triggered manner and to mediate spine development.{55160} It is also found in the pancreas, enteroendocrine cells, and the chromaffin cells of the adrenal medulla where it is involved in hormone secretion.{55161} Decreased expression of SNAP-25 in a heterozygous mouse model leads to moderate hyperactivity, impaired learning and memory, and increased susceptibility to seizures induced by kainate. SNPs in SNAP-25 are associated with attention deficient/hyperactivity disorder, as well as bipolar disorder, schizophrenia, and autism spectrum disorder.{55218} Protein levels of SNAP-25 are decreased in postmortem brain from patients with Down syndrome and Alzheimer’s disease and in postmortem hippocampus from patients with schizophrenia.{52222,55224} Cayman’s SNAP-25 Polyclonal Antibody can be used for Western blot (WB) applications. The antibody recognizes SNAP-25 at 25 kDa from rat samples.
Brand:CaymanSKU:29293 - 100 µlAvailable on backorder
Brand:CaymanSKU:29293- 100 µlAvailable on backorder
SNC 80 is a selective nonpeptide agonist of the δ-opioid receptor (Ki = 0.18 nM, IC50 = 2.73 nM) that is over 2,000-fold less effective at the μ-opioid receptor.{25516,25513,25515} It effectively activates µ/δ receptor heteromers (EC50 = 52.8 nM) but not κ/δ or μ/κ heteromers.{25524} SNC 80 has antinociceptive as well as pro-convulsant effects in vivo.{25516,25513,25514}
Brand:CaymanSKU:- SNC 80 is a selective nonpeptide agonist of the δ-opioid receptor (Ki = 0.18 nM, IC50 = 2.73 nM) that is over 2,000-fold less effective at the μ-opioid receptor.{25516,25513,25515} It effectively activates µ/δ receptor heteromers (EC50 = 52.8 nM) but not κ/δ or μ/κ heteromers.{25524} SNC 80 has antinociceptive as well as pro-convulsant effects in vivo.{25516,25513,25514}
Brand:CaymanSKU:-
SNOB 1 Reagent is a biotinylated probe for detecting S-nitrosylated proteins in a single step. S-Nitrosylated binding (SNOB) proceeds rapidly on surface proteins or cell lysates under normal physiological conditions. Proteins tagged with SNOB 1 Reagent can be analyzed using avidin-linked probes (e.g., by immunoblot) or by mass spectrometry.
Brand:CaymanSKU:-Out of stock
SNOB 1 Reagent is a biotinylated probe for detecting S-nitrosylated proteins in a single step. S-Nitrosylated binding (SNOB) proceeds rapidly on surface proteins or cell lysates under normal physiological conditions. Proteins tagged with SNOB 1 Reagent can be analyzed using avidin-linked probes (e.g., by immunoblot) or by mass spectrometry.
Brand:CaymanSKU:-Out of stock
SNOB 1 Reagent is a biotinylated probe for detecting S-nitrosylated proteins in a single step. S-Nitrosylated binding (SNOB) proceeds rapidly on surface proteins or cell lysates under normal physiological conditions. Proteins tagged with SNOB 1 Reagent can be analyzed using avidin-linked probes (e.g., by immunoblot) or by mass spectrometry.
Brand:CaymanSKU:-Out of stock
Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. SNS-032 is an ATP-competitive inhibitor of Cdk9, 2, and 7 with IC50 values of 4, 38, and 62 nM, respectively.{29268} It is selective for these kinases and displays no additional activity against a panel of 190 kinases (IC50s = >1,000 nM).{29268} SNS-032 can block the cell cycle, inhibit transcription, and induce apoptosis in multiple myeloma RPMI-8226 cells with an IC90 value of 0.3 µM.{29269} This compound has been shown to induce apoptosis by inhibiting the transcription of the anti-apoptotic proteins, Mcl-1 and XIAP.{29270}
Brand:CaymanSKU:-Available on backorder
Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. SNS-032 is an ATP-competitive inhibitor of Cdk9, 2, and 7 with IC50 values of 4, 38, and 62 nM, respectively.{29268} It is selective for these kinases and displays no additional activity against a panel of 190 kinases (IC50s = >1,000 nM).{29268} SNS-032 can block the cell cycle, inhibit transcription, and induce apoptosis in multiple myeloma RPMI-8226 cells with an IC90 value of 0.3 µM.{29269} This compound has been shown to induce apoptosis by inhibiting the transcription of the anti-apoptotic proteins, Mcl-1 and XIAP.{29270}
Brand:CaymanSKU:-Available on backorder
Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. SNS-032 is an ATP-competitive inhibitor of Cdk9, 2, and 7 with IC50 values of 4, 38, and 62 nM, respectively.{29268} It is selective for these kinases and displays no additional activity against a panel of 190 kinases (IC50s = >1,000 nM).{29268} SNS-032 can block the cell cycle, inhibit transcription, and induce apoptosis in multiple myeloma RPMI-8226 cells with an IC90 value of 0.3 µM.{29269} This compound has been shown to induce apoptosis by inhibiting the transcription of the anti-apoptotic proteins, Mcl-1 and XIAP.{29270}
Brand:CaymanSKU:-Available on backorder
Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. SNS-032 is an ATP-competitive inhibitor of Cdk9, 2, and 7 with IC50 values of 4, 38, and 62 nM, respectively.{29268} It is selective for these kinases and displays no additional activity against a panel of 190 kinases (IC50s = >1,000 nM).{29268} SNS-032 can block the cell cycle, inhibit transcription, and induce apoptosis in multiple myeloma RPMI-8226 cells with an IC90 value of 0.3 µM.{29269} This compound has been shown to induce apoptosis by inhibiting the transcription of the anti-apoptotic proteins, Mcl-1 and XIAP.{29270}
Brand:CaymanSKU:-Available on backorder
SNS-062 is an inhibitor of Bruton’s tyrosine kinase (BTK; IC50s = 4.6 and 1.1 nM for wild-type and BTKC481S, respectively).{53166} It also binds to IL2-inducible T cell kinase (Itk; Kd = 2.2 nM) and nine other kinases (Kds = 50 value of 50 nM. It inhibits BTK phosphorylation in B cells isolated from the whole blood of patients with chronic lymphocytic leukemia in a dose-dependent manner.{53166}
Brand:CaymanSKU:29200 - 1 mgAvailable on backorder
SNS-062 is an inhibitor of Bruton’s tyrosine kinase (BTK; IC50s = 4.6 and 1.1 nM for wild-type and BTKC481S, respectively).{53166} It also binds to IL2-inducible T cell kinase (Itk; Kd = 2.2 nM) and nine other kinases (Kds = 50 value of 50 nM. It inhibits BTK phosphorylation in B cells isolated from the whole blood of patients with chronic lymphocytic leukemia in a dose-dependent manner.{53166}
Brand:CaymanSKU:29200 - 10 mgAvailable on backorder
SNS-062 is an inhibitor of Bruton’s tyrosine kinase (BTK; IC50s = 4.6 and 1.1 nM for wild-type and BTKC481S, respectively).{53166} It also binds to IL2-inducible T cell kinase (Itk; Kd = 2.2 nM) and nine other kinases (Kds = 50 value of 50 nM. It inhibits BTK phosphorylation in B cells isolated from the whole blood of patients with chronic lymphocytic leukemia in a dose-dependent manner.{53166}
Brand:CaymanSKU:29200 - 25 mgAvailable on backorder
SNS-062 is an inhibitor of Bruton’s tyrosine kinase (BTK; IC50s = 4.6 and 1.1 nM for wild-type and BTKC481S, respectively).{53166} It also binds to IL2-inducible T cell kinase (Itk; Kd = 2.2 nM) and nine other kinases (Kds = 50 value of 50 nM. It inhibits BTK phosphorylation in B cells isolated from the whole blood of patients with chronic lymphocytic leukemia in a dose-dependent manner.{53166}
Brand:CaymanSKU:29200 - 5 mgAvailable on backorder
SNS-314 is a pan-Aurora kinase inhibitor (IC50s = 9, 31, and 3.4 nM for Aurora A, B, and C, respectively).{35161,35244} In a panel of 219 kinases, SNS-314 also inhibits TRKB, TRKA, FLT4, FMS, DDR2, AXL, and C-RAF (IC50s = 5-100 nM).{35161} SNS-314 inhibits Aurora B phosphorylation of histone H3 in HCT116 human colorectal carcinoma cells in vitro (EC50 = <16 nM) and in a mouse xenograft model at a dose of 50 mg/kg. It also inhibits tumor growth in A2780 ovarian, A375 melanoma, H1299 lung, MDA-MB-231 breast, and PC3 prostate cancer mouse xenograft models when administered biweekly for six weeks at a dose of 170 mg/kg.{35244}
Brand:CaymanSKU:- SNS-314 is a pan-Aurora kinase inhibitor (IC50s = 9, 31, and 3.4 nM for Aurora A, B, and C, respectively).{35161,35244} In a panel of 219 kinases, SNS-314 also inhibits TRKB, TRKA, FLT4, FMS, DDR2, AXL, and C-RAF (IC50s = 5-100 nM).{35161} SNS-314 inhibits Aurora B phosphorylation of histone H3 in HCT116 human colorectal carcinoma cells in vitro (EC50 = <16 nM) and in a mouse xenograft model at a dose of 50 mg/kg. It also inhibits tumor growth in A2780 ovarian, A375 melanoma, H1299 lung, MDA-MB-231 breast, and PC3 prostate cancer mouse xenograft models when administered biweekly for six weeks at a dose of 170 mg/kg.{35244}
Brand:CaymanSKU:- SNS-314 is a pan-Aurora kinase inhibitor (IC50s = 9, 31, and 3.4 nM for Aurora A, B, and C, respectively).{35161,35244} In a panel of 219 kinases, SNS-314 also inhibits TRKB, TRKA, FLT4, FMS, DDR2, AXL, and C-RAF (IC50s = 5-100 nM).{35161} SNS-314 inhibits Aurora B phosphorylation of histone H3 in HCT116 human colorectal carcinoma cells in vitro (EC50 = <16 nM) and in a mouse xenograft model at a dose of 50 mg/kg. It also inhibits tumor growth in A2780 ovarian, A375 melanoma, H1299 lung, MDA-MB-231 breast, and PC3 prostate cancer mouse xenograft models when administered biweekly for six weeks at a dose of 170 mg/kg.{35244}
Brand:CaymanSKU:- SNS-314 is a pan-Aurora kinase inhibitor (IC50s = 9, 31, and 3.4 nM for Aurora A, B, and C, respectively).{35161,35244} In a panel of 219 kinases, SNS-314 also inhibits TRKB, TRKA, FLT4, FMS, DDR2, AXL, and C-RAF (IC50s = 5-100 nM).{35161} SNS-314 inhibits Aurora B phosphorylation of histone H3 in HCT116 human colorectal carcinoma cells in vitro (EC50 = <16 nM) and in a mouse xenograft model at a dose of 50 mg/kg. It also inhibits tumor growth in A2780 ovarian, A375 melanoma, H1299 lung, MDA-MB-231 breast, and PC3 prostate cancer mouse xenograft models when administered biweekly for six weeks at a dose of 170 mg/kg.{35244}
Brand:CaymanSKU:-
SNVP is an S-nitrosothiol that acts as a nitric oxide (NO) donor and vasodilator.{39649} It decompensates to release NO in vitro, an effect that is enhanced by both CuSO4 and cysteine. SNVP induces dose-dependent vasodilation of isolated, precontracted, and endothelium-intact rat arteries (pD2 = 5.74). It also induces sustained vasodilation of isolated, precontracted, and endothelium-denuded rat arteries when used at concentrations greater than 1 μM.
Brand:CaymanSKU:24271 - 10 mgAvailable on backorder
SNVP is an S-nitrosothiol that acts as a nitric oxide (NO) donor and vasodilator.{39649} It decompensates to release NO in vitro, an effect that is enhanced by both CuSO4 and cysteine. SNVP induces dose-dependent vasodilation of isolated, precontracted, and endothelium-intact rat arteries (pD2 = 5.74). It also induces sustained vasodilation of isolated, precontracted, and endothelium-denuded rat arteries when used at concentrations greater than 1 μM.
Brand:CaymanSKU:24271 - 5 mgAvailable on backorder
SNX-2112 is a potent inhibitor of heat shock protein 90 (Hsp90) with a Kd value of 30 nM.{37128} In vitro, SNX-2112 induces down-regulation of the client proteins HER2 and Akt. It inhibits proliferation in a panel of cancer cell lines (IC50s = 10-50 nM). SNX-2112 (150 mg/kg) completely inhibits tumor growth in a BT474 breast cancer mouse xenograft model. SNX-2112 is also the active metabolite of prodrug SNX-5542 and preferentially accumulates in tumor tissue of mice treated with a single oral dose of 75 mg/kg SNX-5542. Formulations containing SNX-2112 are under clinical investigation for treatment of refractory solid tumors.{37129}
Brand:CaymanSKU:22359 -Out of stock
SNX-2112 is a potent inhibitor of heat shock protein 90 (Hsp90) with a Kd value of 30 nM.{37128} In vitro, SNX-2112 induces down-regulation of the client proteins HER2 and Akt. It inhibits proliferation in a panel of cancer cell lines (IC50s = 10-50 nM). SNX-2112 (150 mg/kg) completely inhibits tumor growth in a BT474 breast cancer mouse xenograft model. SNX-2112 is also the active metabolite of prodrug SNX-5542 and preferentially accumulates in tumor tissue of mice treated with a single oral dose of 75 mg/kg SNX-5542. Formulations containing SNX-2112 are under clinical investigation for treatment of refractory solid tumors.{37129}
Brand:CaymanSKU:22359 -Out of stock
SNX-2112 is a potent inhibitor of heat shock protein 90 (Hsp90) with a Kd value of 30 nM.{37128} In vitro, SNX-2112 induces down-regulation of the client proteins HER2 and Akt. It inhibits proliferation in a panel of cancer cell lines (IC50s = 10-50 nM). SNX-2112 (150 mg/kg) completely inhibits tumor growth in a BT474 breast cancer mouse xenograft model. SNX-2112 is also the active metabolite of prodrug SNX-5542 and preferentially accumulates in tumor tissue of mice treated with a single oral dose of 75 mg/kg SNX-5542. Formulations containing SNX-2112 are under clinical investigation for treatment of refractory solid tumors.{37129}
Brand:CaymanSKU:22359 -Out of stock
SNX-2112 is a potent inhibitor of heat shock protein 90 (Hsp90) with a Kd value of 30 nM.{37128} In vitro, SNX-2112 induces down-regulation of the client proteins HER2 and Akt. It inhibits proliferation in a panel of cancer cell lines (IC50s = 10-50 nM). SNX-2112 (150 mg/kg) completely inhibits tumor growth in a BT474 breast cancer mouse xenograft model. SNX-2112 is also the active metabolite of prodrug SNX-5542 and preferentially accumulates in tumor tissue of mice treated with a single oral dose of 75 mg/kg SNX-5542. Formulations containing SNX-2112 are under clinical investigation for treatment of refractory solid tumors.{37129}
Brand:CaymanSKU:22359 -Out of stock
SNX-482 is a peptide originally isolated from H. gigas venom that acts as a class E/R-type voltage-sensitive calcium channel blocker (IC50 = 30 nM in 192C cells expressing human class E channels).{57113} It is selective for class E/R-type over class A and class B calcium channels (IC50s = >280 and ~800 nM, respectively), as well as the voltage-gated potassium channels Kv1.1, Kv1.2, and Kv1.4 (IC50s = >140 nM for all). SNX-482 inhibits class E/R-type calcium currents in isolated rat posterior pituitary (IC50 = 4 nM), however, it has no effect on class E/R-type calcium currents in isolated rat granule cells, retinal ganglion cells, or hippocampal pyramidal cells at concentrations up to 200 nM. Intrathecal administration of SNX-482 (0.5 µg/animal) inhibits formalin-induced neurokinin-1 (NK1) receptor internalization and cfos expression in the ipsilateral dorsal horn and reduces formalin-induced paw flinching in rats.{57114}
Brand:CaymanSKU:30988 - 100 µgAvailable on backorder
Immunogen: Synthetic peptide from the N-terminal region of human SOAT-1/ACAT-1 • Host: Rabbit • Species Reactivity: (+) Human, mouse, porcine, rat • Applications: IF, IHC, WB • MW = ~65 kDa • SOAT-1/ACAT-1 catalyzes the formation of cholesterol esters from cholesterol and long chain fatty acyl-CoA, and may play a role in the development of atherosclerosis.
Brand:CaymanSKU:100028- 1 eaAvailable on backorder
Immunogen: Synthetic peptide from the N-terminal region of human SOAT-1/ACAT-1 • Host: Rabbit • Species Reactivity: (+) Human, mouse, porcine, rat • Applications: IF, IHC, WB • MW = ~65 kDa • SOAT-1/ACAT-1 catalyzes the formation of cholesterol esters from cholesterol and long chain fatty acyl-CoA, and may play a role in the development of atherosclerosis.
Brand:CaymanSKU:100028- 1 ea Sterol O-acyltransferase 1 (SOAT-1), also known as acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1), is an enzyme encoded by ACAT1 in humans that catalyzes the intracellular formation of cholesterol esters from cholesterol and long-chain fatty acyl-coenzyme A.{56232} It is ubiquitously expressed and localized to the rough endoplasmic reticulum where it preferentially utilizes oleic acid (Item Nos. 90260 | 24659) or palmitic acid (Item No. 10006627) as fatty acid substrates for the synthesis of cholesterol esters, which are stored intracellularly or packaged into chylomicrons or VLDL and secreted into the blood stream. SOAT-1/ACAT-1 protein levels are increased in macrophages under various pathological conditions, including atherosclerosis.{56233} SOAT-1/ACAT-1 activity is increased by cholesterol in vitro, and ACAT1 expression is increased by stimulation with the pro-inflammatory cytokines TNF-α or IFN-γ in isolated human and THP-1 monocytes, respectively.{56234,56232} ACAT1 silencing in human H4 neuroglioma cells overexpressing amyloid-β precursor protein (APP) reduces secretion of soluble amyloid-β (Aβ) and Aβ42 (Item No. 20574).{56236} Genome-wide deletion of Acat1 reduces macrophage infiltration and neutral lipid deposition in atherosclerotic aortic lesions and decreases serum total cholesterol levels, but increases brain cholesterol deposition, in ApoE-/- mice fed a Western diet.{56235} Cayman’s SOAT-1/ACAT-1 Polyclonal Antibody can be used for immunoflouresence (IF) immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes the N-terminus to detect full-length SOAT-1/ACAT-1 at approximately 65 kDa from human, mouse, porcine, and rat samples.
Brand:CaymanSKU:100028 - 1 eaAvailable on backorder
Immunogen: Synthetic peptide from the N-terminal region of human SOAT-2/ACAT-2 • Host: Rabbit • Species Reactivity: (+) Human, mouse, ovine, porcine, rat; other species not tested • Cross Reactivity: None listed • Applications: IF, IHC, WB • MW = ~60 kDa
Brand:CaymanSKU:100027- 1 eaAvailable on backorder
Immunogen: Synthetic peptide from the N-terminal region of human SOAT-2/ACAT-2 • Host: Rabbit • Species Reactivity: (+) Human, mouse, ovine, porcine, rat; other species not tested • Cross Reactivity: None listed • Applications: IF, IHC, WB • MW = ~60 kDa
Brand:CaymanSKU:100027- 1 ea Sterol O-acyltransferase 2 (SOAT-2), also known as acyl-coenzyme A:cholesterol acyltransferase-2 (ACAT-2), is an enzyme encoded by ACAT2 in humans that catalyzes the intracellular formation of cholesterol esters from cholesterol and long-chain fatty acyl-coenzyme A.{56232} It is constitutively expressed in the liver and small intestine and localized to the rough endoplasmic reticulum where it preferentially utilizes oleic acid (Item Nos. 90260 | 24659) or palmitic acid (Item No. 10006627) as fatty acid substrates for the synthesis of cholesterol esters, which are stored intracellularly or packaged into chylomicrons or VLDL and secreted into the blood stream. SOAT-2/ACAT-2 protein levels are increased in macrophages under various pathological conditions, including atherosclerosis.{56233} SOAT-2/ACAT-2 activity and protein levels are increased by cholesterol in vitro and in vivo, and ACAT2 expression is increased by the transcription factors hepatocyte nuclear factor 1-α (HNF-1-α) and HNF-4-α in Caco-2 cells and human liver, respectively.{56232} Genome-wide deletion of Acat2 reduces intestinal cholesterol absorption and decreases hepatic, but not plasma, total cholesterol levels in mice fed a high-cholesterol diet.{52780} Liver ACAT2 activity is negatively correlated with plasma HDL-C and ApoA1 in normolipidemic patients.{52781} Cayman’s SOAT-2/ACAT-2 Polyclonal Antibody can be used for immunofluorescence (IF), immunohistochemistry (IHC), and Western blot (WB) applications. The antibody recognizes the N-terminal region of SOAT-2/ACAT-2 at approximately 60 kDa from human, mouse, ovine, porcine, and rat samples.
Brand:CaymanSKU:100027 - 1 eaAvailable on backorder
Sobetirome is an agonist of thyroid hormone receptor β (TRβ; EC50 = 7 nM in a reporter assay).{52772} It selectively binds to TRβ over TRα with Kd values of 0.1 and 1.8 nM, respectively. Sobetirome (97 nmol/kg, i.p.) increases hepatic levels of the HDL receptor SR-B1 and serum levels of C4, a marker of increased bile acid synthesis, in mice fed normal chow or high-cholesterol diets.{52773} It reduces serum cholesterol and triglyceride levels in these same models. Sobetirome (154 nmol/kg, i.p.) also decreases plasma cholesterol levels, without increasing heart rate, in a mouse model of hypothyroidism induced by an iodine-deficient diet containing the thyroid hormone biosynthesis inhibitor 5-propyl-2-thio-uracil.{52774}
Brand:CaymanSKU:30814 - 1 mgAvailable on backorder
Sobetirome is an agonist of thyroid hormone receptor β (TRβ; EC50 = 7 nM in a reporter assay).{52772} It selectively binds to TRβ over TRα with Kd values of 0.1 and 1.8 nM, respectively. Sobetirome (97 nmol/kg, i.p.) increases hepatic levels of the HDL receptor SR-B1 and serum levels of C4, a marker of increased bile acid synthesis, in mice fed normal chow or high-cholesterol diets.{52773} It reduces serum cholesterol and triglyceride levels in these same models. Sobetirome (154 nmol/kg, i.p.) also decreases plasma cholesterol levels, without increasing heart rate, in a mouse model of hypothyroidism induced by an iodine-deficient diet containing the thyroid hormone biosynthesis inhibitor 5-propyl-2-thio-uracil.{52774}
Brand:CaymanSKU:30814 - 10 mgAvailable on backorder
Sobetirome is an agonist of thyroid hormone receptor β (TRβ; EC50 = 7 nM in a reporter assay).{52772} It selectively binds to TRβ over TRα with Kd values of 0.1 and 1.8 nM, respectively. Sobetirome (97 nmol/kg, i.p.) increases hepatic levels of the HDL receptor SR-B1 and serum levels of C4, a marker of increased bile acid synthesis, in mice fed normal chow or high-cholesterol diets.{52773} It reduces serum cholesterol and triglyceride levels in these same models. Sobetirome (154 nmol/kg, i.p.) also decreases plasma cholesterol levels, without increasing heart rate, in a mouse model of hypothyroidism induced by an iodine-deficient diet containing the thyroid hormone biosynthesis inhibitor 5-propyl-2-thio-uracil.{52774}
Brand:CaymanSKU:30814 - 5 mgAvailable on backorder
Brand:CaymanSKU:706001 - 1 eaAvailable on backorder
Brand:CaymanSKU:706001 - 5 eaAvailable on backorder
Brand:CaymanSKU:706004 - 1 eaAvailable on backorder
Brand:CaymanSKU:706003 - 1 eaAvailable on backorder
Brand:CaymanSKU:706003 - 5 eaAvailable on backorder
Brand:CaymanSKU:706006 - 1 eaAvailable on backorder
Sodium 4-phenylbutyrate is a chemical chaperone that has been shown to rescue the trafficking of misfolded proteins.{23406,23405} It also weakly blocks histone deacetylase activity (IC50 = 0.4 mM), which results in cell cycle arrest, differentiation, and/or apoptosis of various tumors.{17643,23404} Formulations containing sodium 4-phenylbutyrate have been used for the treatment of urea cycle disorders.{23403}
Brand:CaymanSKU:11323 - 1 gAvailable on backorder
Sodium 4-phenylbutyrate is a chemical chaperone that has been shown to rescue the trafficking of misfolded proteins.{23406,23405} It also weakly blocks histone deacetylase activity (IC50 = 0.4 mM), which results in cell cycle arrest, differentiation, and/or apoptosis of various tumors.{17643,23404} Formulations containing sodium 4-phenylbutyrate have been used for the treatment of urea cycle disorders.{23403}
Brand:CaymanSKU:11323 - 10 gAvailable on backorder
Sodium 4-phenylbutyrate is a chemical chaperone that has been shown to rescue the trafficking of misfolded proteins.{23406,23405} It also weakly blocks histone deacetylase activity (IC50 = 0.4 mM), which results in cell cycle arrest, differentiation, and/or apoptosis of various tumors.{17643,23404} Formulations containing sodium 4-phenylbutyrate have been used for the treatment of urea cycle disorders.{23403}
Brand:CaymanSKU:11323 - 5 gAvailable on backorder
Sodium 4-Phenylbutyrate-d11 is intended for use as an internal standard for the quantification of sodium 4-phenylbutyrate (Item No. 11323) by GC- or LC-MS. Sodium 4-phenylbutyrate is a chemical chaperone that has been shown to rescue the trafficking of misfolded proteins.{23406,23405} It also weakly blocks histone deacetylase activity (IC50 = 0.4 mM), which results in cell cycle arrest, differentiation, and/or apoptosis of various tumors.{17643,23404} Formulations containing sodium 4-phenylbutyrate have been used for the treatment of urea cycle disorders.
Brand:CaymanSKU:22085 -Out of stock
Sodium 4-Phenylbutyrate-d11 is intended for use as an internal standard for the quantification of sodium 4-phenylbutyrate (Item No. 11323) by GC- or LC-MS. Sodium 4-phenylbutyrate is a chemical chaperone that has been shown to rescue the trafficking of misfolded proteins.{23406,23405} It also weakly blocks histone deacetylase activity (IC50 = 0.4 mM), which results in cell cycle arrest, differentiation, and/or apoptosis of various tumors.{17643,23404} Formulations containing sodium 4-phenylbutyrate have been used for the treatment of urea cycle disorders.
Brand:CaymanSKU:22085 -Out of stock
Brand:CaymanSKU:400037 - 100 dtn (0.82 g)Available on backorder
Brand:CaymanSKU:400037 - 500 dtn (4.1 g)Available on backorder
Sodium butyrate is a short-chain fatty acid.{52278} It is produced predominately by bacterial fermentation of dietary fiber in the colon but has also been identified in mammalian milk.{52278,52279} Sodium butyrate is an inhibitor of histone deacetylase (HDAC; IC50 = 90 µM in a cell-free assay).{52280} It induces differentiation, cell cycle arrest at the G0 phase, and apoptosis, as well as inhibits proliferation, in a variety of cancer cells when used at concentrations ranging from 0.6 to 100 mM.{52279,52281,17300,52282} Sodium butyrate decreases the expression of IFN-γ-related signaling genes and metastatic genes in H460 human lung cancer cells when used at a concentration of 2 mM.{17300} It reduces tumor growth in a CaSki mouse xenograft model when administered at doses of 200 and 800 mg/kg per day.{52281} Sodium butyrate also reduces increases in colonic TNFa and Il6 expression and decreases colonic goblet cell depletion, tissue damage, muscle thickening, and cellular infiltration in a wild-type, but not Hcar2-/-, mouse model of TNBS-induced colitis.{52283}
Brand:CaymanSKU:- Sodium butyrate is a short-chain fatty acid.{52278} It is produced predominately by bacterial fermentation of dietary fiber in the colon but has also been identified in mammalian milk.{52278,52279} Sodium butyrate is an inhibitor of histone deacetylase (HDAC; IC50 = 90 µM in a cell-free assay).{52280} It induces differentiation, cell cycle arrest at the G0 phase, and apoptosis, as well as inhibits proliferation, in a variety of cancer cells when used at concentrations ranging from 0.6 to 100 mM.{52279,52281,17300,52282} Sodium butyrate decreases the expression of IFN-γ-related signaling genes and metastatic genes in H460 human lung cancer cells when used at a concentration of 2 mM.{17300} It reduces tumor growth in a CaSki mouse xenograft model when administered at doses of 200 and 800 mg/kg per day.{52281} Sodium butyrate also reduces increases in colonic TNFa and Il6 expression and decreases colonic goblet cell depletion, tissue damage, muscle thickening, and cellular infiltration in a wild-type, but not Hcar2-/-, mouse model of TNBS-induced colitis.{52283}
Brand:CaymanSKU:- Sodium butyrate is a short-chain fatty acid.{52278} It is produced predominately by bacterial fermentation of dietary fiber in the colon but has also been identified in mammalian milk.{52278,52279} Sodium butyrate is an inhibitor of histone deacetylase (HDAC; IC50 = 90 µM in a cell-free assay).{52280} It induces differentiation, cell cycle arrest at the G0 phase, and apoptosis, as well as inhibits proliferation, in a variety of cancer cells when used at concentrations ranging from 0.6 to 100 mM.{52279,52281,17300,52282} Sodium butyrate decreases the expression of IFN-γ-related signaling genes and metastatic genes in H460 human lung cancer cells when used at a concentration of 2 mM.{17300} It reduces tumor growth in a CaSki mouse xenograft model when administered at doses of 200 and 800 mg/kg per day.{52281} Sodium butyrate also reduces increases in colonic TNFa and Il6 expression and decreases colonic goblet cell depletion, tissue damage, muscle thickening, and cellular infiltration in a wild-type, but not Hcar2-/-, mouse model of TNBS-induced colitis.{52283}
Brand:CaymanSKU:-
Hydrogen sulfide (H2S) is, like nitric oxide, an important gaseous mediator that has significant effects on the immunological, neurological, cardiovascular and pulmonary systems of mammals. Sodium hydrogen sulfide is an H2S donor commonly used in cellular and whole animal experimental systems. For example, it has been used to suggest that H2S promotes neutrophil migration{17227}, reduces airway inflammation{17229}, and protects neurites,{17228} heart,{17225} and intestine{17226} from chemical or ischemic-reperfusion damage.
Brand:CaymanSKU:10012555 - 1 gAvailable on backorder
Hydrogen sulfide (H2S) is, like nitric oxide, an important gaseous mediator that has significant effects on the immunological, neurological, cardiovascular and pulmonary systems of mammals. Sodium hydrogen sulfide is an H2S donor commonly used in cellular and whole animal experimental systems. For example, it has been used to suggest that H2S promotes neutrophil migration{17227}, reduces airway inflammation{17229}, and protects neurites,{17228} heart,{17225} and intestine{17226} from chemical or ischemic-reperfusion damage.
Brand:CaymanSKU:10012555 - 10 gAvailable on backorder
Hydrogen sulfide (H2S) is, like nitric oxide, an important gaseous mediator that has significant effects on the immunological, neurological, cardiovascular and pulmonary systems of mammals. Sodium hydrogen sulfide is an H2S donor commonly used in cellular and whole animal experimental systems. For example, it has been used to suggest that H2S promotes neutrophil migration{17227}, reduces airway inflammation{17229}, and protects neurites,{17228} heart,{17225} and intestine{17226} from chemical or ischemic-reperfusion damage.
Brand:CaymanSKU:10012555 - 25 gAvailable on backorder
Hydrogen sulfide (H2S) is, like nitric oxide, an important gaseous mediator that has significant effects on the immunological, neurological, cardiovascular and pulmonary systems of mammals. Sodium hydrogen sulfide is an H2S donor commonly used in cellular and whole animal experimental systems. For example, it has been used to suggest that H2S promotes neutrophil migration{17227}, reduces airway inflammation{17229}, and protects neurites,{17228} heart,{17225} and intestine{17226} from chemical or ischemic-reperfusion damage.
Brand:CaymanSKU:10012555 - 5 gAvailable on backorder
Brand:CaymanSKU:700017 - 10 mlAvailable on backorder
Sodium ionophore III is a sodium-selective ionophore.{52001,52002} It has been used as component of sodium-selective liquid membrane electrodes for the quantification of sodium in aqueous solutions and blood serum.
Brand:CaymanSKU:22465 -Out of stock
Sodium ionophore III is a sodium-selective ionophore.{52001,52002} It has been used as component of sodium-selective liquid membrane electrodes for the quantification of sodium in aqueous solutions and blood serum.
Brand:CaymanSKU:22465 -Out of stock
Sodium ionophore III is a sodium-selective ionophore.{52001,52002} It has been used as component of sodium-selective liquid membrane electrodes for the quantification of sodium in aqueous solutions and blood serum.
Brand:CaymanSKU:22465 -Out of stock
Sodium ionophore III is a sodium-selective ionophore.{52001,52002} It has been used as component of sodium-selective liquid membrane electrodes for the quantification of sodium in aqueous solutions and blood serum.
Brand:CaymanSKU:22465 -Out of stock
Sodium ionophore VI is a sodium-selective ionophore that can be used in ion-selective electrodes to monitor sodium levels in aqueous solutions.{46423} It is selective for sodium over calcium, magnesium, lithium, ammonium, and potassium ions. Sodium ionophore VI has been used in electrodes to determine the levels of sodium ions in human urine and serum, as well as in X. laevis oocytes.{46424,46425}
Brand:CaymanSKU:27754 - 10 mgAvailable on backorder
Sodium ionophore VI is a sodium-selective ionophore that can be used in ion-selective electrodes to monitor sodium levels in aqueous solutions.{46423} It is selective for sodium over calcium, magnesium, lithium, ammonium, and potassium ions. Sodium ionophore VI has been used in electrodes to determine the levels of sodium ions in human urine and serum, as well as in X. laevis oocytes.{46424,46425}
Brand:CaymanSKU:27754 - 100 mgAvailable on backorder
Sodium ionophore VI is a sodium-selective ionophore that can be used in ion-selective electrodes to monitor sodium levels in aqueous solutions.{46423} It is selective for sodium over calcium, magnesium, lithium, ammonium, and potassium ions. Sodium ionophore VI has been used in electrodes to determine the levels of sodium ions in human urine and serum, as well as in X. laevis oocytes.{46424,46425}
Brand:CaymanSKU:27754 - 50 mgAvailable on backorder
Sodium lauryl sulfoacetate is an anionic surfactant.{46925} It increases proliferation of isolated chicken peripheral blood mononuclear cells (PBMCs) when used at concentrations ranging from 62.5 to 500 µg/ml.{46926} Sodium lauryl sulfoacetate (1, 2, and 4 mg/kg) increases the blood CD4+ to CD8+ T cell ratio induced by a Newcastle disease virus vaccine in chickens. Formulations containing sodium lauryl sulfoacetate have been used as surfactants in the manufacture of cosmetics.
Brand:CaymanSKU:29906 - 100 mgAvailable on backorder