Cayman
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RGD peptide is a synthetic compound made up of the arginine-glycine-aspartate motif that has been extensively used to inhibit integrin-ligand interactions in studies related to cell adhesion, migration, growth, and differentiation.{5588} RGD peptide has also been shown to directly induce apoptosis, independent of integrin-mediated cell clustering or signals, by initiating conformational changes that enhance pro-caspase-3 activation and autoprocessing.{7006,8479}
Brand:CaymanSKU:-
Fibronectin is an extracellular matrix protein which binds other proteins and interacts with cells, serving roles in cell adhesion, migration, and signaling.{5588} Like vitronectin and collagen, fibronectin contains a conserved tripeptide sequence, Arg-Gly-Asp (RGD) to associate with integrins on the cell surface.{3775} RGDS peptide is a tetrapeptide found on fibronectin, fibrinogen α, and von Willebrand factor, but not vitronectin or collagen.{25165,25162} RGDS interacts with α5β1 and αVβ3 integrins.{25166} This tetrapeptide interferes with the attachment of cells to fibronectin-coated surfaces (Ki = 0.6 mM).{25165,25162} It also blocks the attachment of certain pathogens to cells.{25163,25164} RGDS peptide inhibits thrombin-induced binding of platelets to fibronectin, fibrinogen α, and von Willebrand factor (IC50 = ~10 μM).{25165,25167,25168} The interaction of RGDS peptide with cell surface integrins alters intracellular signaling in ways that are cell- and stimulus-specific.{25170,25169}
Brand:CaymanSKU:- Fibronectin is an extracellular matrix protein which binds other proteins and interacts with cells, serving roles in cell adhesion, migration, and signaling.{5588} Like vitronectin and collagen, fibronectin contains a conserved tripeptide sequence, Arg-Gly-Asp (RGD) to associate with integrins on the cell surface.{3775} RGDS peptide is a tetrapeptide found on fibronectin, fibrinogen α, and von Willebrand factor, but not vitronectin or collagen.{25165,25162} RGDS interacts with α5β1 and αVβ3 integrins.{25166} This tetrapeptide interferes with the attachment of cells to fibronectin-coated surfaces (Ki = 0.6 mM).{25165,25162} It also blocks the attachment of certain pathogens to cells.{25163,25164} RGDS peptide inhibits thrombin-induced binding of platelets to fibronectin, fibrinogen α, and von Willebrand factor (IC50 = ~10 μM).{25165,25167,25168} The interaction of RGDS peptide with cell surface integrins alters intracellular signaling in ways that are cell- and stimulus-specific.{25170,25169}
Brand:CaymanSKU:- Fibronectin is an extracellular matrix protein which binds other proteins and interacts with cells, serving roles in cell adhesion, migration, and signaling.{5588} Like vitronectin and collagen, fibronectin contains a conserved tripeptide sequence, Arg-Gly-Asp (RGD) to associate with integrins on the cell surface.{3775} RGDS peptide is a tetrapeptide found on fibronectin, fibrinogen α, and von Willebrand factor, but not vitronectin or collagen.{25165,25162} RGDS interacts with α5β1 and αVβ3 integrins.{25166} This tetrapeptide interferes with the attachment of cells to fibronectin-coated surfaces (Ki = 0.6 mM).{25165,25162} It also blocks the attachment of certain pathogens to cells.{25163,25164} RGDS peptide inhibits thrombin-induced binding of platelets to fibronectin, fibrinogen α, and von Willebrand factor (IC50 = ~10 μM).{25165,25167,25168} The interaction of RGDS peptide with cell surface integrins alters intracellular signaling in ways that are cell- and stimulus-specific.{25170,25169}
Brand:CaymanSKU:- Fibronectin is an extracellular matrix protein which binds other proteins and interacts with cells, serving roles in cell adhesion, migration, and signaling.{5588} Like vitronectin and collagen, fibronectin contains a conserved tripeptide sequence, Arg-Gly-Asp (RGD) to associate with integrins on the cell surface.{3775} RGDS peptide is a tetrapeptide found on fibronectin, fibrinogen α, and von Willebrand factor, but not vitronectin or collagen.{25165,25162} RGDS interacts with α5β1 and αVβ3 integrins.{25166} This tetrapeptide interferes with the attachment of cells to fibronectin-coated surfaces (Ki = 0.6 mM).{25165,25162} It also blocks the attachment of certain pathogens to cells.{25163,25164} RGDS peptide inhibits thrombin-induced binding of platelets to fibronectin, fibrinogen α, and von Willebrand factor (IC50 = ~10 μM).{25165,25167,25168} The interaction of RGDS peptide with cell surface integrins alters intracellular signaling in ways that are cell- and stimulus-specific.{25170,25169}
Brand:CaymanSKU:-
RGFP109 is a brain-penetrant inhibitor of histone deacetylases (HDACs; IC50s = 60 and 50 nM; Kis = 32 and 5 nM for HDAC1 and HDAC3 in cell-free assays, respectively).{33565} It has been shown to upregulate frataxin mRNA levels in cultured cells obtained from Friedreich’s ataxia patients and in a GAA repeat-based mouse model of Friedreich’s ataxia.{33565}
Brand:CaymanSKU:21568 -Out of stock
RGFP109 is a brain-penetrant inhibitor of histone deacetylases (HDACs; IC50s = 60 and 50 nM; Kis = 32 and 5 nM for HDAC1 and HDAC3 in cell-free assays, respectively).{33565} It has been shown to upregulate frataxin mRNA levels in cultured cells obtained from Friedreich’s ataxia patients and in a GAA repeat-based mouse model of Friedreich’s ataxia.{33565}
Brand:CaymanSKU:21568 -Out of stock
RGFP109 is a brain-penetrant inhibitor of histone deacetylases (HDACs; IC50s = 60 and 50 nM; Kis = 32 and 5 nM for HDAC1 and HDAC3 in cell-free assays, respectively).{33565} It has been shown to upregulate frataxin mRNA levels in cultured cells obtained from Friedreich’s ataxia patients and in a GAA repeat-based mouse model of Friedreich’s ataxia.{33565}
Brand:CaymanSKU:21568 -Out of stock
RGFP109 is a brain-penetrant inhibitor of histone deacetylases (HDACs; IC50s = 60 and 50 nM; Kis = 32 and 5 nM for HDAC1 and HDAC3 in cell-free assays, respectively).{33565} It has been shown to upregulate frataxin mRNA levels in cultured cells obtained from Friedreich’s ataxia patients and in a GAA repeat-based mouse model of Friedreich’s ataxia.{33565}
Brand:CaymanSKU:21568 -Out of stock
HDAC3 is highly expressed in brain, and its activity has been associated with negative regulation of learning and memory processes. RGFP966 is a selective inhibitor of HDAC3 (IC50 = 0.08 µM) that does not affect other HDACs at concentrations up to 15 µM.{27557} At 10 mg/kg, RGFP966 can facilitate the extinction of cocaine-seeking behavior and enhance long-term object memory acquisition/consolidation in mice.{27557} At 10 µM, RGFP966 can also induce apoptosis of cutaneous T cell lymphoma cells by disrupting their DNA replication activity.{27558}
Brand:CaymanSKU:-Out of stock
HDAC3 is highly expressed in brain, and its activity has been associated with negative regulation of learning and memory processes. RGFP966 is a selective inhibitor of HDAC3 (IC50 = 0.08 µM) that does not affect other HDACs at concentrations up to 15 µM.{27557} At 10 mg/kg, RGFP966 can facilitate the extinction of cocaine-seeking behavior and enhance long-term object memory acquisition/consolidation in mice.{27557} At 10 µM, RGFP966 can also induce apoptosis of cutaneous T cell lymphoma cells by disrupting their DNA replication activity.{27558}
Brand:CaymanSKU:-Out of stock
HDAC3 is highly expressed in brain, and its activity has been associated with negative regulation of learning and memory processes. RGFP966 is a selective inhibitor of HDAC3 (IC50 = 0.08 µM) that does not affect other HDACs at concentrations up to 15 µM.{27557} At 10 mg/kg, RGFP966 can facilitate the extinction of cocaine-seeking behavior and enhance long-term object memory acquisition/consolidation in mice.{27557} At 10 µM, RGFP966 can also induce apoptosis of cutaneous T cell lymphoma cells by disrupting their DNA replication activity.{27558}
Brand:CaymanSKU:-Out of stock
RGW 611 is a nitroimidazole.{55025} It enhances radiation-induced cell death of hypoxic V79-379A cells.
Brand:CaymanSKU:30067 - 100 mgAvailable on backorder
RGW 611 is a nitroimidazole.{55025} It enhances radiation-induced cell death of hypoxic V79-379A cells.
Brand:CaymanSKU:30067 - 250 mgAvailable on backorder
RGW 611 is a nitroimidazole.{55025} It enhances radiation-induced cell death of hypoxic V79-379A cells.
Brand:CaymanSKU:30067 - 500 mgAvailable on backorder
Ketanserin is a potent antagonist of the serotonin receptor 5-HT2A (Ki = 3.16 nM) that has hypertensive effects in vivo.{26494,26493} RH-34 is a derivative of ketanserin in which the 4-(p-fluorobenzoyl)piperidine group has been replaced with an N-(2-methoxybenzyl) moiety. In phenethylamines, which are 5-HT2A agonists, this addition increases the affinity and selectivity for the 5-HT2A receptor over other serotonin receptors.{20442} The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:- Ketanserin is a potent antagonist of the serotonin receptor 5-HT2A (Ki = 3.16 nM) that has hypertensive effects in vivo.{26494,26493} RH-34 is a derivative of ketanserin in which the 4-(p-fluorobenzoyl)piperidine group has been replaced with an N-(2-methoxybenzyl) moiety. In phenethylamines, which are 5-HT2A agonists, this addition increases the affinity and selectivity for the 5-HT2A receptor over other serotonin receptors.{20442} The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:- Ketanserin is a potent antagonist of the serotonin receptor 5-HT2A (Ki = 3.16 nM) that has hypertensive effects in vivo.{26494,26493} RH-34 is a derivative of ketanserin in which the 4-(p-fluorobenzoyl)piperidine group has been replaced with an N-(2-methoxybenzyl) moiety. In phenethylamines, which are 5-HT2A agonists, this addition increases the affinity and selectivity for the 5-HT2A receptor over other serotonin receptors.{20442} The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:-
Rhamnetin is a flavonoid that has been found in O. falcate and has diverse biological activities.{61082,33775,33776,33774} It reduces production of reactive oxygen species (ROS) and apoptosis induced by miconazole (Item No. 15420) in H9c2 cardiomyocytes.{33775} Rhamnetin inhibits LPS-induced TNF-α and nitric oxide (NO) production in rat neonatal organotypic hippocampal slice cultures (OHSCs) under control conditions and during ethanol withdrawal, as well as NMDA-induced neurotoxicity in OHSCs undergoing ethanol withdrawal.{33776} Dietary administration of rhamnetin (0.1 and 0.2% w/w) reduces serum levels of malondialdehyde (MDA) and liver and erythrocyte levels of thiobarbituric acid reactive substances (TBARS) in rats fed a cholesterol-free diet.{33774} Rhamnetin increases time spent in the target quadrant in the Morris water maze in a rat model of traumatic brain injury.{33777}
Brand:CaymanSKU:20302 -Available on backorder
Rhamnetin is a flavonoid that has been found in O. falcate and has diverse biological activities.{61082,33775,33776,33774} It reduces production of reactive oxygen species (ROS) and apoptosis induced by miconazole (Item No. 15420) in H9c2 cardiomyocytes.{33775} Rhamnetin inhibits LPS-induced TNF-α and nitric oxide (NO) production in rat neonatal organotypic hippocampal slice cultures (OHSCs) under control conditions and during ethanol withdrawal, as well as NMDA-induced neurotoxicity in OHSCs undergoing ethanol withdrawal.{33776} Dietary administration of rhamnetin (0.1 and 0.2% w/w) reduces serum levels of malondialdehyde (MDA) and liver and erythrocyte levels of thiobarbituric acid reactive substances (TBARS) in rats fed a cholesterol-free diet.{33774} Rhamnetin increases time spent in the target quadrant in the Morris water maze in a rat model of traumatic brain injury.{33777}
Brand:CaymanSKU:20302 -Available on backorder
Rhamnetin is a flavonoid that has been found in O. falcate and has diverse biological activities.{61082,33775,33776,33774} It reduces production of reactive oxygen species (ROS) and apoptosis induced by miconazole (Item No. 15420) in H9c2 cardiomyocytes.{33775} Rhamnetin inhibits LPS-induced TNF-α and nitric oxide (NO) production in rat neonatal organotypic hippocampal slice cultures (OHSCs) under control conditions and during ethanol withdrawal, as well as NMDA-induced neurotoxicity in OHSCs undergoing ethanol withdrawal.{33776} Dietary administration of rhamnetin (0.1 and 0.2% w/w) reduces serum levels of malondialdehyde (MDA) and liver and erythrocyte levels of thiobarbituric acid reactive substances (TBARS) in rats fed a cholesterol-free diet.{33774} Rhamnetin increases time spent in the target quadrant in the Morris water maze in a rat model of traumatic brain injury.{33777}
Brand:CaymanSKU:20302 -Available on backorder
Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity. It is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50 = 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens.{17506} At higher concentrations, rhapontigenin inhibits the proliferation of HepG2 and HL-60R cancer cell lines (IC50 = 48 μM).{17507,17129}
Brand:CaymanSKU:- Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity. It is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50 = 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens.{17506} At higher concentrations, rhapontigenin inhibits the proliferation of HepG2 and HL-60R cancer cell lines (IC50 = 48 μM).{17507,17129}
Brand:CaymanSKU:- Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity. It is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50 = 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens.{17506} At higher concentrations, rhapontigenin inhibits the proliferation of HepG2 and HL-60R cancer cell lines (IC50 = 48 μM).{17507,17129}
Brand:CaymanSKU:- Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity. It is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50 = 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens.{17506} At higher concentrations, rhapontigenin inhibits the proliferation of HepG2 and HL-60R cancer cell lines (IC50 = 48 μM).{17507,17129}
Brand:CaymanSKU:-
Rhapontin is a natural stilbenoid glycoside first isolated from rhubarb rhizomes. It is converted by glucosidases to rhapontigenin (Item No. 13293), a resveratrol analog with antioxidant and anti-cancer activity.{17506,17507,17129} Rhapontigenin derived enzymatically from rhapontin has also been found to have antibiotic activity as well as inhibit melanin synthesis.{31770,31771}
Brand:CaymanSKU:19867 -Available on backorder
Rhapontin is a natural stilbenoid glycoside first isolated from rhubarb rhizomes. It is converted by glucosidases to rhapontigenin (Item No. 13293), a resveratrol analog with antioxidant and anti-cancer activity.{17506,17507,17129} Rhapontigenin derived enzymatically from rhapontin has also been found to have antibiotic activity as well as inhibit melanin synthesis.{31770,31771}
Brand:CaymanSKU:19867 -Available on backorder
Rhapontin is a natural stilbenoid glycoside first isolated from rhubarb rhizomes. It is converted by glucosidases to rhapontigenin (Item No. 13293), a resveratrol analog with antioxidant and anti-cancer activity.{17506,17507,17129} Rhapontigenin derived enzymatically from rhapontin has also been found to have antibiotic activity as well as inhibit melanin synthesis.{31770,31771}
Brand:CaymanSKU:19867 -Available on backorder
Rhapontin is a natural stilbenoid glycoside first isolated from rhubarb rhizomes. It is converted by glucosidases to rhapontigenin (Item No. 13293), a resveratrol analog with antioxidant and anti-cancer activity.{17506,17507,17129} Rhapontigenin derived enzymatically from rhapontin has also been found to have antibiotic activity as well as inhibit melanin synthesis.{31770,31771}
Brand:CaymanSKU:19867 -Available on backorder
Diacylglycerol (DAG) is an important cellular source of arachidonic acid (Item No. 90010) which may be released by the action of DAG lipase (DAGL). RHC-80267 is a selective inhibitor of DAGL (IC50 = 4 µM in canine platelets) that demonstrates relatively weak inhibition of phospholipases A2 and C.{27089} By elevating the concentration of diacylglycerol, RHC-80267 is thought to initiate activation of protein kinase C.{27090} At 0.3-1 µM, it has been reported to enhance acetylcholine-induced smooth muscle relaxation in vitro.{27090}
Brand:CaymanSKU:-Out of stock
Diacylglycerol (DAG) is an important cellular source of arachidonic acid (Item No. 90010) which may be released by the action of DAG lipase (DAGL). RHC-80267 is a selective inhibitor of DAGL (IC50 = 4 µM in canine platelets) that demonstrates relatively weak inhibition of phospholipases A2 and C.{27089} By elevating the concentration of diacylglycerol, RHC-80267 is thought to initiate activation of protein kinase C.{27090} At 0.3-1 µM, it has been reported to enhance acetylcholine-induced smooth muscle relaxation in vitro.{27090}
Brand:CaymanSKU:-Out of stock
Diacylglycerol (DAG) is an important cellular source of arachidonic acid (Item No. 90010) which may be released by the action of DAG lipase (DAGL). RHC-80267 is a selective inhibitor of DAGL (IC50 = 4 µM in canine platelets) that demonstrates relatively weak inhibition of phospholipases A2 and C.{27089} By elevating the concentration of diacylglycerol, RHC-80267 is thought to initiate activation of protein kinase C.{27090} At 0.3-1 µM, it has been reported to enhance acetylcholine-induced smooth muscle relaxation in vitro.{27090}
Brand:CaymanSKU:-Out of stock
Diacylglycerol (DAG) is an important cellular source of arachidonic acid (Item No. 90010) which may be released by the action of DAG lipase (DAGL). RHC-80267 is a selective inhibitor of DAGL (IC50 = 4 µM in canine platelets) that demonstrates relatively weak inhibition of phospholipases A2 and C.{27089} By elevating the concentration of diacylglycerol, RHC-80267 is thought to initiate activation of protein kinase C.{27090} At 0.3-1 µM, it has been reported to enhance acetylcholine-induced smooth muscle relaxation in vitro.{27090}
Brand:CaymanSKU:-Out of stock
Rhein is an anthraquinone derivative that has been found in R. rhabarbarum and a metabolite of diacerein (Item No. 11710) that has diverse biological activities, including anticancer, antioxidant, and anti-inflammatory activities.{46597,28413,46596,28415} It induces cell cycle arrest at the S phase and inhibits the proliferation of HepG2 cells when used at concentrations of 40 and 100 µM, respectively.{46597} Rhein (100 and 200 µM) also inhibits proliferation of MCF-7 and MDA-MB-435s breast cancer cells under normoxic and hypoxic conditions.{28413} It reduces controlled cortical impact-induced decreases in catalase and superoxide dismutase (SOD) activity and malondialdehyde (MDA), glutathione, and glutathione disulfide levels in the brain in a rat model of traumatic brain injury when administered at a dose of 12 mg/kg.{46596} Rhein (50 mg/kg per day) reduces increased serum TNF-α, IL-1β, and amylase levels, as well as reduces pancreatic glandular atrophy and fibrosis, in a mouse model of chronic pancreatitis induced by cerulein.{28415}
Brand:CaymanSKU:-Available on backorder
Rhein is an anthraquinone derivative that has been found in R. rhabarbarum and a metabolite of diacerein (Item No. 11710) that has diverse biological activities, including anticancer, antioxidant, and anti-inflammatory activities.{46597,28413,46596,28415} It induces cell cycle arrest at the S phase and inhibits the proliferation of HepG2 cells when used at concentrations of 40 and 100 µM, respectively.{46597} Rhein (100 and 200 µM) also inhibits proliferation of MCF-7 and MDA-MB-435s breast cancer cells under normoxic and hypoxic conditions.{28413} It reduces controlled cortical impact-induced decreases in catalase and superoxide dismutase (SOD) activity and malondialdehyde (MDA), glutathione, and glutathione disulfide levels in the brain in a rat model of traumatic brain injury when administered at a dose of 12 mg/kg.{46596} Rhein (50 mg/kg per day) reduces increased serum TNF-α, IL-1β, and amylase levels, as well as reduces pancreatic glandular atrophy and fibrosis, in a mouse model of chronic pancreatitis induced by cerulein.{28415}
Brand:CaymanSKU:-Available on backorder
Rhein is an anthraquinone derivative that has been found in R. rhabarbarum and a metabolite of diacerein (Item No. 11710) that has diverse biological activities, including anticancer, antioxidant, and anti-inflammatory activities.{46597,28413,46596,28415} It induces cell cycle arrest at the S phase and inhibits the proliferation of HepG2 cells when used at concentrations of 40 and 100 µM, respectively.{46597} Rhein (100 and 200 µM) also inhibits proliferation of MCF-7 and MDA-MB-435s breast cancer cells under normoxic and hypoxic conditions.{28413} It reduces controlled cortical impact-induced decreases in catalase and superoxide dismutase (SOD) activity and malondialdehyde (MDA), glutathione, and glutathione disulfide levels in the brain in a rat model of traumatic brain injury when administered at a dose of 12 mg/kg.{46596} Rhein (50 mg/kg per day) reduces increased serum TNF-α, IL-1β, and amylase levels, as well as reduces pancreatic glandular atrophy and fibrosis, in a mouse model of chronic pancreatitis induced by cerulein.{28415}
Brand:CaymanSKU:-Available on backorder
Rhein is an anthraquinone derivative that has been found in R. rhabarbarum and a metabolite of diacerein (Item No. 11710) that has diverse biological activities, including anticancer, antioxidant, and anti-inflammatory activities.{46597,28413,46596,28415} It induces cell cycle arrest at the S phase and inhibits the proliferation of HepG2 cells when used at concentrations of 40 and 100 µM, respectively.{46597} Rhein (100 and 200 µM) also inhibits proliferation of MCF-7 and MDA-MB-435s breast cancer cells under normoxic and hypoxic conditions.{28413} It reduces controlled cortical impact-induced decreases in catalase and superoxide dismutase (SOD) activity and malondialdehyde (MDA), glutathione, and glutathione disulfide levels in the brain in a rat model of traumatic brain injury when administered at a dose of 12 mg/kg.{46596} Rhein (50 mg/kg per day) reduces increased serum TNF-α, IL-1β, and amylase levels, as well as reduces pancreatic glandular atrophy and fibrosis, in a mouse model of chronic pancreatitis induced by cerulein.{28415}
Brand:CaymanSKU:-Available on backorder
Rhein-13C4 is intended for use as an internal standard for the quantification of rhein (Item No. 17345) by GC- or LC-MS. Rhein is an anthraquinone derivative that has been found in R. rhabarbarum and a metabolite of diacerein (Item No. 11710) that has diverse biological activities, including anticancer, antioxidant, and anti-inflammatory activities.{46596,46597,28413,28415} It induces cell cycle arrest at the S phase and inhibits the proliferation of HepG2 cells when used at concentrations of 40 and 100 µM, respectively.{46597} Rhein (100 and 200 µM) also inhibits proliferation of MCF-7 and MDA-MB-435s breast cancer cells under normoxic and hypoxic conditions.{28413} It reduces controlled cortical impact-induced decreases in catalase and superoxide dismutase (SOD) activity and malondialdehyde (MDA), glutathione, and glutathione disulfide levels in the brain in a rat model of traumatic brain injury when administered at a dose of 12 mg/kg.{46596} Rhein (50 mg/kg per day) reduces increased serum TNF-α, IL-1β, and amylase levels, as well as reduces pancreatic glandular atrophy and fibrosis, in a mouse model of chronic pancreatitis induced by cerulein.{28415}
Brand:CaymanSKU:28803 - 1 mgAvailable on backorder
Rhein-8-glucoside is an anthraquinone glycoside that has been found in rhubarb.{46524} It increases the rate of sennoside A (Item No. 24969) metabolism by mouse intestinal bacteria in vitro when used at concentrations ranging from 0.03 to 1 mM. Rhein-8-glucoside increases the purgative activity of sennoside A in mice in a dose-dependent manner. It also inhibits human protein tyrosine phosphatase (PTP1B; IC50 = 11.5 μM).{46525} Rhein-8-glucoside is metabolized to rhein (Item No. 17345) by intestinal bacteria.{46524}
Brand:CaymanSKU:28844 - 1 mgAvailable on backorder
Rhein-8-glucoside is an anthraquinone glycoside that has been found in rhubarb.{46524} It increases the rate of sennoside A (Item No. 24969) metabolism by mouse intestinal bacteria in vitro when used at concentrations ranging from 0.03 to 1 mM. Rhein-8-glucoside increases the purgative activity of sennoside A in mice in a dose-dependent manner. It also inhibits human protein tyrosine phosphatase (PTP1B; IC50 = 11.5 μM).{46525} Rhein-8-glucoside is metabolized to rhein (Item No. 17345) by intestinal bacteria.{46524}
Brand:CaymanSKU:28844 - 10 mgAvailable on backorder
Rhein-8-glucoside is an anthraquinone glycoside that has been found in rhubarb.{46524} It increases the rate of sennoside A (Item No. 24969) metabolism by mouse intestinal bacteria in vitro when used at concentrations ranging from 0.03 to 1 mM. Rhein-8-glucoside increases the purgative activity of sennoside A in mice in a dose-dependent manner. It also inhibits human protein tyrosine phosphatase (PTP1B; IC50 = 11.5 μM).{46525} Rhein-8-glucoside is metabolized to rhein (Item No. 17345) by intestinal bacteria.{46524}
Brand:CaymanSKU:28844 - 25 mgAvailable on backorder
Rhein-8-glucoside is an anthraquinone glycoside that has been found in rhubarb.{46524} It increases the rate of sennoside A (Item No. 24969) metabolism by mouse intestinal bacteria in vitro when used at concentrations ranging from 0.03 to 1 mM. Rhein-8-glucoside increases the purgative activity of sennoside A in mice in a dose-dependent manner. It also inhibits human protein tyrosine phosphatase (PTP1B; IC50 = 11.5 μM).{46525} Rhein-8-glucoside is metabolized to rhein (Item No. 17345) by intestinal bacteria.{46524}
Brand:CaymanSKU:28844 - 5 mgAvailable on backorder
Rhod-2 (potassium salt) is a water-soluble, red fluorescent calcium indicator. It exhibits a significant shift in fluorescence intensity upon calcium binding (ex max = 549 nm; calcium-free v. ex/em max = 552/581 nm; calcium-bound).{30853,23813} Unlike the UV-excitable indicators fura-2 (Item Nos. 19531 | 20414) and indo-1 (Item Nos. 20419 | 20418), there is no accompanying spectral shift.
Brand:CaymanSKU:20777 -Available on backorder
Rhod-2 AM is an acetoxymethyl (AM) ester of the red fluorescent calcium indicator rhod-2. The AM group facilitates cellular uptake and is removed by cytoplasmic esterases, resulting in intracellular accumulation of rhod-2.{23813,30852,30853} Rhod-2 AM selectively accumulates within mitochondria and, as a result, is commonly used to monitor calcium changes within this organelle.{30854,30850,30851} Excitation and emission maxima are 557 and 581 nm, respectively.{30853}
Brand:CaymanSKU:-Available on backorder
Rhod-5N is a low affinity fluorescent calcium probe (Kd = 320 µM).{30853} Low affinity calcium indicators are particularly useful for studying compartments with high concentrations of calcium, such as endoplasmic reticulum, where high affinity dyes will be insensitive to luminal fluctuations. Rhod-5N has excitation/emission maxima of approximately 551 and 576 nm, respectively
Brand:CaymanSKU:20441 -Available on backorder
Rhodamine 101 (inner salt) is a bright fluorescent dye with excitation and emission maxima of 565 and 595 nm, respectively.{32275,32276} It can be used in various biological applications such as fluorescence microscopy, flow cytometry, fluorescence correlation spectroscopy, and ELISA.
Brand:CaymanSKU:20654 -Available on backorder
Rhodamine 101 (inner salt) is a bright fluorescent dye with excitation and emission maxima of 565 and 595 nm, respectively.{32275,32276} It can be used in various biological applications such as fluorescence microscopy, flow cytometry, fluorescence correlation spectroscopy, and ELISA.
Brand:CaymanSKU:20654 -Available on backorder
Rhodamine 101 (inner salt) is a bright fluorescent dye with excitation and emission maxima of 565 and 595 nm, respectively.{32275,32276} It can be used in various biological applications such as fluorescence microscopy, flow cytometry, fluorescence correlation spectroscopy, and ELISA.
Brand:CaymanSKU:20654 -Available on backorder
Rhodamine 110 is a green fluorescent cationic dye with excitation and emission maxima of 496 and 520 nm, respectively.{35313} When incorporated with a hydrolytic substrate (e.g., proteinase or peptidase substrates), it can be used as a highly sensitive detection reagent in fluorescence-based enzyme assays.{30487} Rhodamine 110 has also been used in a fluorescence quenching method for determining trace nitrite and as a probe for cytochrome P450 activity.{30489,30488}
Brand:CaymanSKU:-Available on backorder
Rhodamine 110 is a green fluorescent cationic dye with excitation and emission maxima of 496 and 520 nm, respectively.{35313} When incorporated with a hydrolytic substrate (e.g., proteinase or peptidase substrates), it can be used as a highly sensitive detection reagent in fluorescence-based enzyme assays.{30487} Rhodamine 110 has also been used in a fluorescence quenching method for determining trace nitrite and as a probe for cytochrome P450 activity.{30489,30488}
Brand:CaymanSKU:-Available on backorder
Rhodamine 123 is a membrane-permeable cationic dye that is readily accumulated within living cells.{27856} It is a substrate for the efflux pump P-glycoprotein (P-gp; also known as multidrug resistance protein 1 and ABCB1) and is rapidly exported from cells with functional P-gp.{27854,27855} As P-gp is expressed on a population of stem cells known as the side population, rhodamine 123 is used to detect this group of stem cells.{27855,27857} Rhodamine 123 also accumulates within mitochondria due to its positive charge and can inhibit oxidative phosphorylation.{27856,27853} Rhodamine 123 has excitation/emission maxima of 507/529 nm.{42160}
Brand:CaymanSKU:-Out of stock
Rhodamine 123 is a membrane-permeable cationic dye that is readily accumulated within living cells.{27856} It is a substrate for the efflux pump P-glycoprotein (P-gp; also known as multidrug resistance protein 1 and ABCB1) and is rapidly exported from cells with functional P-gp.{27854,27855} As P-gp is expressed on a population of stem cells known as the side population, rhodamine 123 is used to detect this group of stem cells.{27855,27857} Rhodamine 123 also accumulates within mitochondria due to its positive charge and can inhibit oxidative phosphorylation.{27856,27853} Rhodamine 123 has excitation/emission maxima of 507/529 nm.{42160}
Brand:CaymanSKU:-Out of stock
Rhodamine 123 is a membrane-permeable cationic dye that is readily accumulated within living cells.{27856} It is a substrate for the efflux pump P-glycoprotein (P-gp; also known as multidrug resistance protein 1 and ABCB1) and is rapidly exported from cells with functional P-gp.{27854,27855} As P-gp is expressed on a population of stem cells known as the side population, rhodamine 123 is used to detect this group of stem cells.{27855,27857} Rhodamine 123 also accumulates within mitochondria due to its positive charge and can inhibit oxidative phosphorylation.{27856,27853} Rhodamine 123 has excitation/emission maxima of 507/529 nm.{42160}
Brand:CaymanSKU:-Out of stock
Rhodamine 123 is a membrane-permeable cationic dye that is readily accumulated within living cells.{27856} It is a substrate for the efflux pump P-glycoprotein (P-gp; also known as multidrug resistance protein 1 and ABCB1) and is rapidly exported from cells with functional P-gp.{27854,27855} As P-gp is expressed on a population of stem cells known as the side population, rhodamine 123 is used to detect this group of stem cells.{27855,27857} Rhodamine 123 also accumulates within mitochondria due to its positive charge and can inhibit oxidative phosphorylation.{27856,27853} Rhodamine 123 has excitation/emission maxima of 507/529 nm.{42160}
Brand:CaymanSKU:-Out of stock
Rhodamine B hydrazide is a water-soluble fluorescent probe with excitation/emission spectra of 510/578 nm, respectively.{39268} It has been used for the detection of copper, peroxynitrite, nitric oxide, hydrogen peroxide, glucose, diacetyl, and hemoglobin.{39268,39269,39270,39271,39272,39273}
Brand:CaymanSKU:23133 - 10 mgAvailable on backorder
Rhodamine B hydrazide is a water-soluble fluorescent probe with excitation/emission spectra of 510/578 nm, respectively.{39268} It has been used for the detection of copper, peroxynitrite, nitric oxide, hydrogen peroxide, glucose, diacetyl, and hemoglobin.{39268,39269,39270,39271,39272,39273}
Brand:CaymanSKU:23133 - 100 mgAvailable on backorder
Rhodamine B hydrazide is a water-soluble fluorescent probe with excitation/emission spectra of 510/578 nm, respectively.{39268} It has been used for the detection of copper, peroxynitrite, nitric oxide, hydrogen peroxide, glucose, diacetyl, and hemoglobin.{39268,39269,39270,39271,39272,39273}
Brand:CaymanSKU:23133 - 25 mgAvailable on backorder
Rhodamine B hydrazide is a water-soluble fluorescent probe with excitation/emission spectra of 510/578 nm, respectively.{39268} It has been used for the detection of copper, peroxynitrite, nitric oxide, hydrogen peroxide, glucose, diacetyl, and hemoglobin.{39268,39269,39270,39271,39272,39273}
Brand:CaymanSKU:23133 - 5 mgAvailable on backorder
Rhodamine B isothiocyanate (RITC) is a cell-permeant fluorogenic dye most often used as a conjugate to antibodies and proteins for fluorescence detection in microscopy.{34254} It displays excitation/emission maxima of 570/595 nm, respectively, and can be used in conjunction with immunohistochemistry for multi-labeling studies.{34188} It has also been used as an anterograde and retrograde tracer in neurons and in nanoparticles to detect apoptosis.{34190,34189,34187}
Brand:CaymanSKU:20653 -Available on backorder
Rhodamine B isothiocyanate (RITC) is a cell-permeant fluorogenic dye most often used as a conjugate to antibodies and proteins for fluorescence detection in microscopy.{34254} It displays excitation/emission maxima of 570/595 nm, respectively, and can be used in conjunction with immunohistochemistry for multi-labeling studies.{34188} It has also been used as an anterograde and retrograde tracer in neurons and in nanoparticles to detect apoptosis.{34190,34189,34187}
Brand:CaymanSKU:20653 -Available on backorder
Rhodamine B isothiocyanate (RITC) is a cell-permeant fluorogenic dye most often used as a conjugate to antibodies and proteins for fluorescence detection in microscopy.{34254} It displays excitation/emission maxima of 570/595 nm, respectively, and can be used in conjunction with immunohistochemistry for multi-labeling studies.{34188} It has also been used as an anterograde and retrograde tracer in neurons and in nanoparticles to detect apoptosis.{34190,34189,34187}
Brand:CaymanSKU:20653 -Available on backorder
Rhodamine B isothiocyanate (RITC) is a cell-permeant fluorogenic dye most often used as a conjugate to antibodies and proteins for fluorescence detection in microscopy.{34254} It displays excitation/emission maxima of 570/595 nm, respectively, and can be used in conjunction with immunohistochemistry for multi-labeling studies.{34188} It has also been used as an anterograde and retrograde tracer in neurons and in nanoparticles to detect apoptosis.{34190,34189,34187}
Brand:CaymanSKU:20653 -Available on backorder
RI-1 is an irreversible inhibitor of RAD51 (IC50s = 5-30 µM), a protein that is central to homologous recombination during DNA repair and is overexpressed in a wide range of human cancer cell types.{40763,31181} RI-1 selectively inhibits homologous recombination without inhibiting single strand annealing.{40763} It binds directly to the C319 thiol of RAD51 and inhibits oligomerization of RAD51 filaments. In vitro, RI-1 sensitizes cancer cells to chemotherapeutics that generate interstrand DNA crosslinks, including HEK293 cells co-treated with mitomycin C (LD50 = 16.62 µM).{40763,31181}
Brand:CaymanSKU:24182 - 1 mgAvailable on backorder
RI-1 is an irreversible inhibitor of RAD51 (IC50s = 5-30 µM), a protein that is central to homologous recombination during DNA repair and is overexpressed in a wide range of human cancer cell types.{40763,31181} RI-1 selectively inhibits homologous recombination without inhibiting single strand annealing.{40763} It binds directly to the C319 thiol of RAD51 and inhibits oligomerization of RAD51 filaments. In vitro, RI-1 sensitizes cancer cells to chemotherapeutics that generate interstrand DNA crosslinks, including HEK293 cells co-treated with mitomycin C (LD50 = 16.62 µM).{40763,31181}
Brand:CaymanSKU:24182 - 10 mgAvailable on backorder
RI-1 is an irreversible inhibitor of RAD51 (IC50s = 5-30 µM), a protein that is central to homologous recombination during DNA repair and is overexpressed in a wide range of human cancer cell types.{40763,31181} RI-1 selectively inhibits homologous recombination without inhibiting single strand annealing.{40763} It binds directly to the C319 thiol of RAD51 and inhibits oligomerization of RAD51 filaments. In vitro, RI-1 sensitizes cancer cells to chemotherapeutics that generate interstrand DNA crosslinks, including HEK293 cells co-treated with mitomycin C (LD50 = 16.62 µM).{40763,31181}
Brand:CaymanSKU:24182 - 25 mgAvailable on backorder
RI-1 is an irreversible inhibitor of RAD51 (IC50s = 5-30 µM), a protein that is central to homologous recombination during DNA repair and is overexpressed in a wide range of human cancer cell types.{40763,31181} RI-1 selectively inhibits homologous recombination without inhibiting single strand annealing.{40763} It binds directly to the C319 thiol of RAD51 and inhibits oligomerization of RAD51 filaments. In vitro, RI-1 sensitizes cancer cells to chemotherapeutics that generate interstrand DNA crosslinks, including HEK293 cells co-treated with mitomycin C (LD50 = 16.62 µM).{40763,31181}
Brand:CaymanSKU:24182 - 5 mgAvailable on backorder
RI-2 is a reversible inhibitor of RAD51 (IC50 = 44.2 µM), a protein that is central to the homologous recombination process initiated upon DNA double-strand breaks and is often overexpressed in a wide range of human cancer cell types.{31181} At 150 µM, it has been shown to inhibit DNA repair and to sensitize cancer cells to cross-linking chemotherapy in vitro.{31181}
Brand:CaymanSKU:-Available on backorder
RI-2 is a reversible inhibitor of RAD51 (IC50 = 44.2 µM), a protein that is central to the homologous recombination process initiated upon DNA double-strand breaks and is often overexpressed in a wide range of human cancer cell types.{31181} At 150 µM, it has been shown to inhibit DNA repair and to sensitize cancer cells to cross-linking chemotherapy in vitro.{31181}
Brand:CaymanSKU:-Available on backorder
RI-2 is a reversible inhibitor of RAD51 (IC50 = 44.2 µM), a protein that is central to the homologous recombination process initiated upon DNA double-strand breaks and is often overexpressed in a wide range of human cancer cell types.{31181} At 150 µM, it has been shown to inhibit DNA repair and to sensitize cancer cells to cross-linking chemotherapy in vitro.{31181}
Brand:CaymanSKU:-Available on backorder
RI-2 is a reversible inhibitor of RAD51 (IC50 = 44.2 µM), a protein that is central to the homologous recombination process initiated upon DNA double-strand breaks and is often overexpressed in a wide range of human cancer cell types.{31181} At 150 µM, it has been shown to inhibit DNA repair and to sensitize cancer cells to cross-linking chemotherapy in vitro.{31181}
Brand:CaymanSKU:-Available on backorder
Ribavirin is an antiviral guanosine nucleoside analog.{29248,59186} Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 µg/ml).{59187} Ribavirin also reduces replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero cells (EC50 = 109.5 µM).{45843} Aerosol administration of ribavirin (30 mg/kg) reduces mortality in a mouse model of influenza A infection.{59188} Formulations containing ribavirin have been used in the treatment of respiratory syncytial virus (RSV), hepatitis C virus (HCV), and viral hemorrhagic fevers.
Brand:CaymanSKU:-Out of stock
Ribavirin is an antiviral guanosine nucleoside analog.{29248,59186} Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 µg/ml).{59187} Ribavirin also reduces replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero cells (EC50 = 109.5 µM).{45843} Aerosol administration of ribavirin (30 mg/kg) reduces mortality in a mouse model of influenza A infection.{59188} Formulations containing ribavirin have been used in the treatment of respiratory syncytial virus (RSV), hepatitis C virus (HCV), and viral hemorrhagic fevers.
Brand:CaymanSKU:-Out of stock
Ribavirin is an antiviral guanosine nucleoside analog.{29248,59186} Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 µg/ml).{59187} Ribavirin also reduces replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero cells (EC50 = 109.5 µM).{45843} Aerosol administration of ribavirin (30 mg/kg) reduces mortality in a mouse model of influenza A infection.{59188} Formulations containing ribavirin have been used in the treatment of respiratory syncytial virus (RSV), hepatitis C virus (HCV), and viral hemorrhagic fevers.
Brand:CaymanSKU:-Out of stock
Ribavirin is an antiviral guanosine nucleoside analog.{29248,59186} Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 µg/ml).{59187} Ribavirin also reduces replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero cells (EC50 = 109.5 µM).{45843} Aerosol administration of ribavirin (30 mg/kg) reduces mortality in a mouse model of influenza A infection.{59188} Formulations containing ribavirin have been used in the treatment of respiratory syncytial virus (RSV), hepatitis C virus (HCV), and viral hemorrhagic fevers.
Brand:CaymanSKU:-Out of stock
Ribavirin 5′-monophosphate inhibits viral DNA and RNA replication in vitro via the strong competitive inhibition of inosine monophosphate dehydrogenase (IMPDH), with a reported Ki value of 270 nM, and thus inhibits guanosine triphosphate synthesis.{34338,34337,29247} This agent, a metabolite of the prodrug ribavirin (Item No. 16757), exhibits broad-spectrum antiviral activity, particularly against myxoviruses.{34337,29247} The antiviral effects of ribavirin require conversion to the monophosphate form via adenosine kinase.{34338,29247} The anti-HIV activity of ribavirin in cultured human lymphocytes, as well as the anti-influenza activity of this prodrug in MDCK cells, have been attributed to ribavirin 5′-monophosphate.{34335,34336}
Brand:CaymanSKU:21821 -Out of stock
Ribavirin 5′-monophosphate inhibits viral DNA and RNA replication in vitro via the strong competitive inhibition of inosine monophosphate dehydrogenase (IMPDH), with a reported Ki value of 270 nM, and thus inhibits guanosine triphosphate synthesis.{34338,34337,29247} This agent, a metabolite of the prodrug ribavirin (Item No. 16757), exhibits broad-spectrum antiviral activity, particularly against myxoviruses.{34337,29247} The antiviral effects of ribavirin require conversion to the monophosphate form via adenosine kinase.{34338,29247} The anti-HIV activity of ribavirin in cultured human lymphocytes, as well as the anti-influenza activity of this prodrug in MDCK cells, have been attributed to ribavirin 5′-monophosphate.{34335,34336}
Brand:CaymanSKU:21821 -Out of stock
Ribavirin 5′-monophosphate inhibits viral DNA and RNA replication in vitro via the strong competitive inhibition of inosine monophosphate dehydrogenase (IMPDH), with a reported Ki value of 270 nM, and thus inhibits guanosine triphosphate synthesis.{34338,34337,29247} This agent, a metabolite of the prodrug ribavirin (Item No. 16757), exhibits broad-spectrum antiviral activity, particularly against myxoviruses.{34337,29247} The antiviral effects of ribavirin require conversion to the monophosphate form via adenosine kinase.{34338,29247} The anti-HIV activity of ribavirin in cultured human lymphocytes, as well as the anti-influenza activity of this prodrug in MDCK cells, have been attributed to ribavirin 5′-monophosphate.{34335,34336}
Brand:CaymanSKU:21821 -Out of stock
Ribitol is a pentose sugar alcohol derived from ribose in vivo via the pentose phosphate pathway.{48440} It is a component of the glycopolymer teichoic acid in bacterial cell walls.{48441} Levels of ribitol are increased in the brain, cerebrospinal fluid, urine, and plasma of a patient with ribose-5-phosphate isomerase (RPI) deficiency, an extremely rare inborn error of metabolism characterized by a heterozygous frameshift mutation and missense allele in the RPI gene leading to leukoencephalopathy and mild peripheral polyneuropathy.{48440}
Brand:CaymanSKU:27362 - 10 gAvailable on backorder
Ribitol is a pentose sugar alcohol derived from ribose in vivo via the pentose phosphate pathway.{48440} It is a component of the glycopolymer teichoic acid in bacterial cell walls.{48441} Levels of ribitol are increased in the brain, cerebrospinal fluid, urine, and plasma of a patient with ribose-5-phosphate isomerase (RPI) deficiency, an extremely rare inborn error of metabolism characterized by a heterozygous frameshift mutation and missense allele in the RPI gene leading to leukoencephalopathy and mild peripheral polyneuropathy.{48440}
Brand:CaymanSKU:27362 - 100 gAvailable on backorder
Ribitol is a pentose sugar alcohol derived from ribose in vivo via the pentose phosphate pathway.{48440} It is a component of the glycopolymer teichoic acid in bacterial cell walls.{48441} Levels of ribitol are increased in the brain, cerebrospinal fluid, urine, and plasma of a patient with ribose-5-phosphate isomerase (RPI) deficiency, an extremely rare inborn error of metabolism characterized by a heterozygous frameshift mutation and missense allele in the RPI gene leading to leukoencephalopathy and mild peripheral polyneuropathy.{48440}
Brand:CaymanSKU:27362 - 25 gAvailable on backorder
Ribitol is a pentose sugar alcohol derived from ribose in vivo via the pentose phosphate pathway.{48440} It is a component of the glycopolymer teichoic acid in bacterial cell walls.{48441} Levels of ribitol are increased in the brain, cerebrospinal fluid, urine, and plasma of a patient with ribose-5-phosphate isomerase (RPI) deficiency, an extremely rare inborn error of metabolism characterized by a heterozygous frameshift mutation and missense allele in the RPI gene leading to leukoencephalopathy and mild peripheral polyneuropathy.{48440}
Brand:CaymanSKU:27362 - 50 gAvailable on backorder