Cayman
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15-hydroxy Pentadecanoic acid methyl ester is a hydroxylated fatty acid methyl ester that is a key intermediate in the synthesis of the musk-odored macrocyclic lactones cyclopentadecanolide and exaltolide.{41602,41603} [Matreya, LLC. Catalog No. 1882]
Brand:CaymanSKU:24649 - 10 mgAvailable on backorder
15-hydroxy Pentadecanoic acid methyl ester is a hydroxylated fatty acid methyl ester that is a key intermediate in the synthesis of the musk-odored macrocyclic lactones cyclopentadecanolide and exaltolide.{41602,41603} [Matreya, LLC. Catalog No. 1882]
Brand:CaymanSKU:24649 - 25 mgAvailable on backorder
15-hydroxy Pentadecanoic acid methyl ester is a hydroxylated fatty acid methyl ester that is a key intermediate in the synthesis of the musk-odored macrocyclic lactones cyclopentadecanolide and exaltolide.{41602,41603} [Matreya, LLC. Catalog No. 1882]
Brand:CaymanSKU:24649 - 5 mgAvailable on backorder
Immunogen: Synthetic peptide from an internal region of human 15-hydroxy PGDH • Host: Rabbit • Species Reactivity: (+) Human, baboon, and mouse • Application: WB
Brand:CaymanSKU:160615- 1 ea NAD+-dependent 15-hydroxy PGDH catalyzes the oxidation of prostaglandins to 15-keto metabolites, which have greatly reduced biological activity.{340} Human NAD+-dependent 15-hydroxy PGDH is a 266 amino acid protein with a molecular weight of 29 kDa and is expressed in multiple tissues including lung, placenta, and kidney.{387} The enzyme belongs to a large family of short-chain alcohol dehydrogenases, which exhibit amino acid identity ranging from 15-30%.{8277,5201} An NADP+-dependent 15-hydroxy PGDH, which is also part of this enzyme family, exhibits only 20% amino acid identity to the NAD+-dependent enzyme.{8401} The peptide used as the antigen for preparation of the 15-hydroxy PGDH antibody is highly conserved across several species (see above), but has only minor homology to other proteins within the short-chain alcohol dehydrogenase family of enzymes (only the alanine and glycine at the N-terminus of the sequence appear to be conserved).{8277} Cayman’s 15-hydroxy PGDH Polyclonal Antibody can be used for Western blot applications. The antibody recognizes 15-hydroxy PGDH at 29 kDa from human, baboon, and mouse samples.
Brand:CaymanSKU:160615 - 1 eaAvailable on backorder
Immunogen: Synthetic peptide from an internal region of human 15-hydroxy PGDH • Host: Rabbit • Species Reactivity: (+) Human, baboon, and mouse • Application: WB
Brand:CaymanSKU:160615- 1 eaAvailable on backorder
Travoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug.{8839,9613} Oxidation of the C-15 hydroxyl group without isopropyl ester hydrolysis produces 15-keto fluprostenol isopropyl ester (15-keto travoprost). 15-keto Travoprost is a potential metabolite of travoprost when administered to intact animals. 15-keto Travoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. In general, F-series prostaglandin analogs with a 15-keto functional group lose a great deal of their FP receptor binding affinity, but retain enough to show a continued weak IOP hypotensive response.{3586} The efficacy of 15-keto travoprost as an ocular hypotensive has not been established.
Brand:CaymanSKU:-Out of stock
Travoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug.{8839,9613} Oxidation of the C-15 hydroxyl group without isopropyl ester hydrolysis produces 15-keto fluprostenol isopropyl ester (15-keto travoprost). 15-keto Travoprost is a potential metabolite of travoprost when administered to intact animals. 15-keto Travoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. In general, F-series prostaglandin analogs with a 15-keto functional group lose a great deal of their FP receptor binding affinity, but retain enough to show a continued weak IOP hypotensive response.{3586} The efficacy of 15-keto travoprost as an ocular hypotensive has not been established.
Brand:CaymanSKU:-Out of stock
Travoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug.{8839,9613} Oxidation of the C-15 hydroxyl group without isopropyl ester hydrolysis produces 15-keto fluprostenol isopropyl ester (15-keto travoprost). 15-keto Travoprost is a potential metabolite of travoprost when administered to intact animals. 15-keto Travoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. In general, F-series prostaglandin analogs with a 15-keto functional group lose a great deal of their FP receptor binding affinity, but retain enough to show a continued weak IOP hypotensive response.{3586} The efficacy of 15-keto travoprost as an ocular hypotensive has not been established.
Brand:CaymanSKU:-Out of stock
Travoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug.{8839,9613} Oxidation of the C-15 hydroxyl group without isopropyl ester hydrolysis produces 15-keto fluprostenol isopropyl ester (15-keto travoprost). 15-keto Travoprost is a potential metabolite of travoprost when administered to intact animals. 15-keto Travoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. In general, F-series prostaglandin analogs with a 15-keto functional group lose a great deal of their FP receptor binding affinity, but retain enough to show a continued weak IOP hypotensive response.{3586} The efficacy of 15-keto travoprost as an ocular hypotensive has not been established.
Brand:CaymanSKU:-Out of stock
Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug.{1107} Oxidation of the C-15 hydroxyl group without isopropyl ester hydrolysis produces 15-keto latanoprost. 15-keto Latanoprost is a potential metabolite of latanoprost when administered to animals. 15-keto Latanoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. Although much less potent that the parent compound latanoprost, 15-keto latanoprost still retains the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 µg/eye.{1107} 15-keto Latanoprost is also a miotic in the normal cat eye, causing an 8 mm reduction in pupillary diameter at 5 µg/eye.{1107} Again, this is not as potent as many other F-type PGs; for example, PGF2α will produce this degree of miosis at a dose of less than 1 µg/eye. Products of β-oxidation account for most of the metabolites of latanoprost recovered in plasma and urine. However, 15-keto latanoprost is a minor metabolite, and one which could be enhanced in situations where β-oxidation is reduced.
Brand:CaymanSKU:-Out of stock
Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug.{1107} Oxidation of the C-15 hydroxyl group without isopropyl ester hydrolysis produces 15-keto latanoprost. 15-keto Latanoprost is a potential metabolite of latanoprost when administered to animals. 15-keto Latanoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. Although much less potent that the parent compound latanoprost, 15-keto latanoprost still retains the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 µg/eye.{1107} 15-keto Latanoprost is also a miotic in the normal cat eye, causing an 8 mm reduction in pupillary diameter at 5 µg/eye.{1107} Again, this is not as potent as many other F-type PGs; for example, PGF2α will produce this degree of miosis at a dose of less than 1 µg/eye. Products of β-oxidation account for most of the metabolites of latanoprost recovered in plasma and urine. However, 15-keto latanoprost is a minor metabolite, and one which could be enhanced in situations where β-oxidation is reduced.
Brand:CaymanSKU:-Out of stock
Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug.{1107} Oxidation of the C-15 hydroxyl group without isopropyl ester hydrolysis produces 15-keto latanoprost. 15-keto Latanoprost is a potential metabolite of latanoprost when administered to animals. 15-keto Latanoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. Although much less potent that the parent compound latanoprost, 15-keto latanoprost still retains the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 µg/eye.{1107} 15-keto Latanoprost is also a miotic in the normal cat eye, causing an 8 mm reduction in pupillary diameter at 5 µg/eye.{1107} Again, this is not as potent as many other F-type PGs; for example, PGF2α will produce this degree of miosis at a dose of less than 1 µg/eye. Products of β-oxidation account for most of the metabolites of latanoprost recovered in plasma and urine. However, 15-keto latanoprost is a minor metabolite, and one which could be enhanced in situations where β-oxidation is reduced.
Brand:CaymanSKU:-Out of stock
15-keto Latanoprost is a potential metabolite of latanoprost when administered to animals. 15-keto Latanoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. Although much less potent that the parent compound latanoprost, 15-keto latanoprost still retains the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 µg/eye.{1107} 15-keto Latanoprost is also a miotic in the normal cat eye, causing an 8 mm Hg reduction in pupillary diameter at 5 µg/eye. Again, this is not as potent as many other F-type prostaglandins; for example, prostaglandin F2α will produce this degree of miosis at a dose of less than 1 µg/eye.{1107}
Brand:CaymanSKU:-Out of stock
15-keto Latanoprost is a potential metabolite of latanoprost when administered to animals. 15-keto Latanoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. Although much less potent that the parent compound latanoprost, 15-keto latanoprost still retains the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 µg/eye.{1107} 15-keto Latanoprost is also a miotic in the normal cat eye, causing an 8 mm Hg reduction in pupillary diameter at 5 µg/eye. Again, this is not as potent as many other F-type prostaglandins; for example, prostaglandin F2α will produce this degree of miosis at a dose of less than 1 µg/eye.{1107}
Brand:CaymanSKU:-Out of stock
15-keto Latanoprost is a potential metabolite of latanoprost when administered to animals. 15-keto Latanoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. Although much less potent that the parent compound latanoprost, 15-keto latanoprost still retains the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 µg/eye.{1107} 15-keto Latanoprost is also a miotic in the normal cat eye, causing an 8 mm Hg reduction in pupillary diameter at 5 µg/eye. Again, this is not as potent as many other F-type prostaglandins; for example, prostaglandin F2α will produce this degree of miosis at a dose of less than 1 µg/eye.{1107}
Brand:CaymanSKU:-Out of stock
Prostaglandin A1 (PGA1) (Item No. 10010) was first isolated as a dehydration product of the PGE1 (Item No. 13010) compounds found in human semen.{411} 15-keto PGA1 is a metabolite of PGA1, produced by 15-hydroxy PG dehydrogenase.{24573} It can be produced from PGA1 in pig lung, trachea, aorta, and pulmonary artery tissue preparations.{24573} 15-keto PGA1, given at a concentration of 6 µM, causes vasoconstriction of rabbit lung that is comparable to that induced by angiotensin II.{24574}
Brand:CaymanSKU:9000142 - 1 mgAvailable on backorder
Prostaglandin A1 (PGA1) (Item No. 10010) was first isolated as a dehydration product of the PGE1 (Item No. 13010) compounds found in human semen.{411} 15-keto PGA1 is a metabolite of PGA1, produced by 15-hydroxy PG dehydrogenase.{24573} It can be produced from PGA1 in pig lung, trachea, aorta, and pulmonary artery tissue preparations.{24573} 15-keto PGA1, given at a concentration of 6 µM, causes vasoconstriction of rabbit lung that is comparable to that induced by angiotensin II.{24574}
Brand:CaymanSKU:9000142 - 5 mgAvailable on backorder
Prostaglandin A1 (PGA1) (Item No. 10010) was first isolated as a dehydration product of the PGE1 (Item No. 13010) compounds found in human semen.{411} 15-keto PGA1 is a metabolite of PGA1, produced by 15-hydroxy PG dehydrogenase.{24573} It can be produced from PGA1 in pig lung, trachea, aorta, and pulmonary artery tissue preparations.{24573} 15-keto PGA1, given at a concentration of 6 µM, causes vasoconstriction of rabbit lung that is comparable to that induced by angiotensin II.{24574}
Brand:CaymanSKU:9000142 - 500 µgAvailable on backorder
15-keto PGE1 is the inactive metabolite of PGE1 produced by 15-hydroxy PGDH. It has greatly diminished biological activity compared to PGE1.{4165,4168}
Brand:CaymanSKU:- 15-keto PGE1 is the inactive metabolite of PGE1 produced by 15-hydroxy PGDH. It has greatly diminished biological activity compared to PGE1.{4165,4168}
Brand:CaymanSKU:- 15-keto PGE1 is the inactive metabolite of PGE1 produced by 15-hydroxy PGDH. It has greatly diminished biological activity compared to PGE1.{4165,4168}
Brand:CaymanSKU:- 15-keto PGE1 is the inactive metabolite of PGE1 produced by 15-hydroxy PGDH. It has greatly diminished biological activity compared to PGE1.{4165,4168}
Brand:CaymanSKU:-
15-keto Prostaglandin E2 (15-keto PGE2) is a metabolite of PGE2 (Item No. 14010) formed by 15-hydroxy PGDH.{182,389} In vivo, 15-keto PGE2 is essentially inactive. It has an attenuated affinity for the EP4 and EP2 receptors compared to PGE2 (Ki = 2,600-15,000 nM for the inhibition of PGE2 binding compared to a Kd = 1 nM for PGE2).{2777}
Brand:CaymanSKU:- 15-keto Prostaglandin E2 (15-keto PGE2) is a metabolite of PGE2 (Item No. 14010) formed by 15-hydroxy PGDH.{182,389} In vivo, 15-keto PGE2 is essentially inactive. It has an attenuated affinity for the EP4 and EP2 receptors compared to PGE2 (Ki = 2,600-15,000 nM for the inhibition of PGE2 binding compared to a Kd = 1 nM for PGE2).{2777}
Brand:CaymanSKU:- 15-keto Prostaglandin E2 (15-keto PGE2) is a metabolite of PGE2 (Item No. 14010) formed by 15-hydroxy PGDH.{182,389} In vivo, 15-keto PGE2 is essentially inactive. It has an attenuated affinity for the EP4 and EP2 receptors compared to PGE2 (Ki = 2,600-15,000 nM for the inhibition of PGE2 binding compared to a Kd = 1 nM for PGE2).{2777}
Brand:CaymanSKU:- 15-keto Prostaglandin E2 (15-keto PGE2) is a metabolite of PGE2 (Item No. 14010) formed by 15-hydroxy PGDH.{182,389} In vivo, 15-keto PGE2 is essentially inactive. It has an attenuated affinity for the EP4 and EP2 receptors compared to PGE2 (Ki = 2,600-15,000 nM for the inhibition of PGE2 binding compared to a Kd = 1 nM for PGE2).{2777}
Brand:CaymanSKU:-
15-keto Prostaglandin E2 (15-keto PGE2) is a metabolite of PGE2 (Item Nos. 14010 | 10007211) formed by 15-hydroxy PGDH (Item No. 360615).{182,389} In vivo, 15-keto PGE2 is essentially inactive. It has an attenuated affinity for the EP4 and EP2 receptors compared to PGE2 (Ki = 2,600-15,000 nM for the inhibition of PGE2 binding compared to a Kd = 1 nM for PGE2).{2777} 15-keto PGE2 MaxSpec® standard is a quantitative grade standard of 15-keto PGE2 (Item No. 14720) that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This 15-keto PGE2 MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.
Brand:CaymanSKU:10007215 - 100 µgAvailable on backorder
15-keto PGF1α is the initial metabolite of PGF1α via 15-hydroxy PGDH. In mammals, oxidation of C-15 markedly attenuates receptor binding and activity. In fish, the 15-keto compounds serve as post-ovulatory pheromones and are more active than the parent prostaglandins.{1586}
Brand:CaymanSKU:- 15-keto PGF1α is the initial metabolite of PGF1α via 15-hydroxy PGDH. In mammals, oxidation of C-15 markedly attenuates receptor binding and activity. In fish, the 15-keto compounds serve as post-ovulatory pheromones and are more active than the parent prostaglandins.{1586}
Brand:CaymanSKU:- 15-keto PGF1α is the initial metabolite of PGF1α via 15-hydroxy PGDH. In mammals, oxidation of C-15 markedly attenuates receptor binding and activity. In fish, the 15-keto compounds serve as post-ovulatory pheromones and are more active than the parent prostaglandins.{1586}
Brand:CaymanSKU:-
15-keto Prostaglandin F1α (PGF1α) is the initial metabolite of PGF1α formed via 15-hydroxy prostaglandin dehydrogenase (15-PGDH). In fish, the 15-keto compounds serve as post-ovulatory pheromones and are more active than the parent prostaglandins.{1586} 15-keto Prostaglandin F1α MaxSpec® standard is a quantitative grade standard of 15-keto Prostaglandin F1α (Item No. 15710) that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This 15-keto Prostaglandin F1α MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.
Brand:CaymanSKU:25902 - 100 µgAvailable on backorder
15-keto Prostaglandin F2α (15-keto PGF2α) is the first metabolite of PGF2α. in the 15-hydroxy PGDH pathway. It is one of the critical components in the goldfish and Atlantic salmon postovulatory pheromone.{1586,3467} 15-keto PGF2α stimulates the male goldfish and salmon olfactory receptors with detection thresholds of 10-12 and 10-8 M, respectively.{1586,3467} 15-keto PGF2α is 10-fold less active than PGF2α in decreasing rabbit intraocular pressure.{2396}
Brand:CaymanSKU:-Out of stock
15-keto Prostaglandin F2α (15-keto PGF2α) is the first metabolite of PGF2α. in the 15-hydroxy PGDH pathway. It is one of the critical components in the goldfish and Atlantic salmon postovulatory pheromone.{1586,3467} 15-keto PGF2α stimulates the male goldfish and salmon olfactory receptors with detection thresholds of 10-12 and 10-8 M, respectively.{1586,3467} 15-keto PGF2α is 10-fold less active than PGF2α in decreasing rabbit intraocular pressure.{2396}
Brand:CaymanSKU:-Out of stock
15-keto Prostaglandin F2α (15-keto PGF2α) is the first metabolite of PGF2α. in the 15-hydroxy PGDH pathway. It is one of the critical components in the goldfish and Atlantic salmon postovulatory pheromone.{1586,3467} 15-keto PGF2α stimulates the male goldfish and salmon olfactory receptors with detection thresholds of 10-12 and 10-8 M, respectively.{1586,3467} 15-keto PGF2α is 10-fold less active than PGF2α in decreasing rabbit intraocular pressure.{2396}
Brand:CaymanSKU:-Out of stock
15-keto Prostaglandin F2α (15-keto PGF2α) is the first metabolite of PGF2α (Item Nos. 16010 | 10007221). in the 15-hydroxy PGDH pathway. It is one of the critical components in the goldfish and Atlantic salmon postovulatory pheromone.{1586,3467} 15-keto PGF2α stimulates the male goldfish and salmon olfactory receptors with detection thresholds of 10-12 and 10-8 M, respectively.{1586,3467} 15-keto PGF2α is 10-fold less active than PGF2α in decreasing rabbit intraocular pressure.{2396} 15-keto PGF2α MaxSpec® standard is a quantitative grade standard of 15-keto PGF2α (Item No. 16720) that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This 15-keto PGF2α MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.
Brand:CaymanSKU:10007227 - 100 µgAvailable on backorder
Bimatoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug.{8838} Oxidation of the C-15 hydroxyl group and amide hydrolysis of Bimatoprost produces 15-keto-17-phenyl trinor PGF2α. 15-keto-17-phenyl trinor PGF2α is a potential metabolite of bimatoprost when administered to animals. 15-keto PG analogs are potential minor impurities in commercial preparations of their corresponding bulk drug compounds. Although much less potent that the parent compound, 15-keto PGs still retain the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 µg/eye.{1107} 15-keto Latanoprost (15-keto-17-phenyl-13,14-dihydro trinor PGF2α isopropyl ester) is a miotic in the normal cat eye, causing an 8 mm reduction in pupillary diameter at 5 µg/eye. Again, this is not as potent as many other F-type PGs; for example, PGF2α will produce this degree of miosis at a dose of less than 1 µg/eye.
Brand:CaymanSKU:-Out of stock
Bimatoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug.{8838} Oxidation of the C-15 hydroxyl group and amide hydrolysis of Bimatoprost produces 15-keto-17-phenyl trinor PGF2α. 15-keto-17-phenyl trinor PGF2α is a potential metabolite of bimatoprost when administered to animals. 15-keto PG analogs are potential minor impurities in commercial preparations of their corresponding bulk drug compounds. Although much less potent that the parent compound, 15-keto PGs still retain the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 µg/eye.{1107} 15-keto Latanoprost (15-keto-17-phenyl-13,14-dihydro trinor PGF2α isopropyl ester) is a miotic in the normal cat eye, causing an 8 mm reduction in pupillary diameter at 5 µg/eye. Again, this is not as potent as many other F-type PGs; for example, PGF2α will produce this degree of miosis at a dose of less than 1 µg/eye.
Brand:CaymanSKU:-Out of stock
Bimatoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug.{8838} Oxidation of the C-15 hydroxyl group and amide hydrolysis of Bimatoprost produces 15-keto-17-phenyl trinor PGF2α. 15-keto-17-phenyl trinor PGF2α is a potential metabolite of bimatoprost when administered to animals. 15-keto PG analogs are potential minor impurities in commercial preparations of their corresponding bulk drug compounds. Although much less potent that the parent compound, 15-keto PGs still retain the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 µg/eye.{1107} 15-keto Latanoprost (15-keto-17-phenyl-13,14-dihydro trinor PGF2α isopropyl ester) is a miotic in the normal cat eye, causing an 8 mm reduction in pupillary diameter at 5 µg/eye. Again, this is not as potent as many other F-type PGs; for example, PGF2α will produce this degree of miosis at a dose of less than 1 µg/eye.
Brand:CaymanSKU:-Out of stock
Bimatoprost is the Allergan trade name for 17-phenyl trinor prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide), an F-series PG analog which has been approved for use as an ocular hypotensive drug.{8941} Oxidation of the C-15 hydroxyl group produces 15-keto-17-phenyl trinor PGF2α ethyl amide. 15-keto-17-phenyl trinor PGF2α ethyl amide is a potential metabolite of 17-phenyl trinor PGF2α ethyl amide when 17-phenyl trinor PGF2α ethyl amide is administered to intact animals. No pharmacological studies on 15-keto-17-phenyl trinor PGF2α ethyl amide have been reported.
Brand:CaymanSKU:10010405 - 1 mgAvailable on backorder
Bimatoprost is the Allergan trade name for 17-phenyl trinor prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide), an F-series PG analog which has been approved for use as an ocular hypotensive drug.{8941} Oxidation of the C-15 hydroxyl group produces 15-keto-17-phenyl trinor PGF2α ethyl amide. 15-keto-17-phenyl trinor PGF2α ethyl amide is a potential metabolite of 17-phenyl trinor PGF2α ethyl amide when 17-phenyl trinor PGF2α ethyl amide is administered to intact animals. No pharmacological studies on 15-keto-17-phenyl trinor PGF2α ethyl amide have been reported.
Brand:CaymanSKU:10010405 - 10 mgAvailable on backorder
Bimatoprost is the Allergan trade name for 17-phenyl trinor prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide), an F-series PG analog which has been approved for use as an ocular hypotensive drug.{8941} Oxidation of the C-15 hydroxyl group produces 15-keto-17-phenyl trinor PGF2α ethyl amide. 15-keto-17-phenyl trinor PGF2α ethyl amide is a potential metabolite of 17-phenyl trinor PGF2α ethyl amide when 17-phenyl trinor PGF2α ethyl amide is administered to intact animals. No pharmacological studies on 15-keto-17-phenyl trinor PGF2α ethyl amide have been reported.
Brand:CaymanSKU:10010405 - 25 mgAvailable on backorder
Bimatoprost is the Allergan trade name for 17-phenyl trinor prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide), an F-series PG analog which has been approved for use as an ocular hypotensive drug.{8941} Oxidation of the C-15 hydroxyl group produces 15-keto-17-phenyl trinor PGF2α ethyl amide. 15-keto-17-phenyl trinor PGF2α ethyl amide is a potential metabolite of 17-phenyl trinor PGF2α ethyl amide when 17-phenyl trinor PGF2α ethyl amide is administered to intact animals. No pharmacological studies on 15-keto-17-phenyl trinor PGF2α ethyl amide have been reported.
Brand:CaymanSKU:10010405 - 5 mgAvailable on backorder
Lipoxygenases (LOs) are non-heme iron-containing dioxygenases that catalyze the oxidation of polyunsaturated fatty acids to generate unsaturated fatty acid hydroperoxides.{3140} The immediate products of 15-LO fatty acid oxidation act as mediators in inflammation, thrombosis, and cancer.{12192} 15-Lipoxygenases (15-LO) inhibitor 1 is a heterocyclic pyrimidobenzothiazine compound that inhibits 15-LO with an IC50 value of 18 µM.{15014} The inhibitor appears to act as an antioxidant, interfering with the redox cycle of 15-LO.{15014}
Brand:CaymanSKU:10010468 - 1 mgAvailable on backorder
Lipoxygenases (LOs) are non-heme iron-containing dioxygenases that catalyze the oxidation of polyunsaturated fatty acids to generate unsaturated fatty acid hydroperoxides.{3140} The immediate products of 15-LO fatty acid oxidation act as mediators in inflammation, thrombosis, and cancer.{12192} 15-Lipoxygenases (15-LO) inhibitor 1 is a heterocyclic pyrimidobenzothiazine compound that inhibits 15-LO with an IC50 value of 18 µM.{15014} The inhibitor appears to act as an antioxidant, interfering with the redox cycle of 15-LO.{15014}
Brand:CaymanSKU:10010468 - 10 mgAvailable on backorder
Lipoxygenases (LOs) are non-heme iron-containing dioxygenases that catalyze the oxidation of polyunsaturated fatty acids to generate unsaturated fatty acid hydroperoxides.{3140} The immediate products of 15-LO fatty acid oxidation act as mediators in inflammation, thrombosis, and cancer.{12192} 15-Lipoxygenases (15-LO) inhibitor 1 is a heterocyclic pyrimidobenzothiazine compound that inhibits 15-LO with an IC50 value of 18 µM.{15014} The inhibitor appears to act as an antioxidant, interfering with the redox cycle of 15-LO.{15014}
Brand:CaymanSKU:10010468 - 5 mgAvailable on backorder
Lipoxygenases (LOs) are non-heme iron-containing dioxygenases that catalyze the oxidation of polyunsaturated fatty acids to generate unsaturated fatty acid hydroperoxides.{3140} The immediate products of 15-LO fatty acid oxidation act as mediators in inflammation, thrombosis, and cancer.{12192} 15-Lipoxygenases (15-LO) inhibitor 1 is a heterocyclic pyrimidobenzothiazine compound that inhibits 15-LO with an IC50 value of 18 µM.{15014} The inhibitor appears to act as an antioxidant, interfering with the redox cycle of 15-LO.{15014}
Brand:CaymanSKU:10010468 - 500 µgAvailable on backorder
Antigen: human 15-LO-2 amino acids 161-179 • Host: rabbit • Species Reactivity: (+) Human 15-Lipoxygenase-2; • Cross Reactivity: (−) rabbit reticulocyte 15-LO-1 and porcine leukocyte 12-LO-1 • Applications: ICC, IHC, and WB • 15-LO-2 oxygenates C15 of arachidonic acid to produce 15(S)-HETE. Expression of 15-LO-2 appears to be restriced to prostate, lung, skin, and cornea and may play a role in the normal development of these tissues.
Brand:CaymanSKU:10004454- 1 eaAvailable on backorder
Antigen: human 15-LO-2 amino acids 161-179 • Host: rabbit • Species Reactivity: (+) Human 15-Lipoxygenase-2; • Cross Reactivity: (−) rabbit reticulocyte 15-LO-1 and porcine leukocyte 12-LO-1 • Applications: ICC, IHC, and WB • 15-LO-2 oxygenates C15 of arachidonic acid to produce 15(S)-HETE. Expression of 15-LO-2 appears to be restriced to prostate, lung, skin, and cornea and may play a role in the normal development of these tissues.
Brand:CaymanSKU:10004454- 1 ea Two types of 15-LO have been discovered and characterized, both of which metabolize arachidonic acid (AA) to produce 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE). 15-LO-1 oxygenates AA at both C15 and C12,{11792} whereas 15-LO-2 exclusively oxygenates C15 of AA.{4675} Human 15-LO-2 has a molecular mass of approximately 76 kDa and exhibits approximately 40% identity to the reticulocyte 15-LO-1.{4675,11789} Expression of 15-LO-2 appears to be restricted to prostate, lung, skin, and cornea and may play a role in the normal development of these tissues.{11790} The protein levels and enzymatic activity of 15-LO-2 are both down-regulated in prostate cancer compared with normal and benign prostate tissues, implicating a possible protective role for 15-LO-2 against tumor formation.{11790,8774,9075} Cayman Chemical’s 15-LO-2 polyclonal antibody can be used for western blot analysis for 15-LO-2 on samples of human origin. Other applications for use of this antibody have not yet been tested.
Brand:CaymanSKU:10004454 - 1 eaAvailable on backorder
15-methyl Palmitic acid is a methylated fatty acid that has been found in bacteria, bovine milk fat, one-humped camel (C. dromedarius) meat and fat, and in rabbit perirenal lipids.{40922,40923,40924,36633} It is also found in human breast milk and levels are decreased in mature breast milk compared to colostrum.{40925}
Brand:CaymanSKU:24814 - 10 mgAvailable on backorder
15-methyl Palmitic acid is a methylated fatty acid that has been found in bacteria, bovine milk fat, one-humped camel (C. dromedarius) meat and fat, and in rabbit perirenal lipids.{40922,40923,40924,36633} It is also found in human breast milk and levels are decreased in mature breast milk compared to colostrum.{40925}
Brand:CaymanSKU:24814 - 25 mgAvailable on backorder
15-methyl Palmitic acid is a methylated fatty acid that has been found in bacteria, bovine milk fat, one-humped camel (C. dromedarius) meat and fat, and in rabbit perirenal lipids.{40922,40923,40924,36633} It is also found in human breast milk and levels are decreased in mature breast milk compared to colostrum.{40925}
Brand:CaymanSKU:24814 - 5 mgAvailable on backorder
15-methyl Palmitic acid methyl ester is a methylated fatty acid methyl ester that has been found in S. zeai sea sponges as the fatty acyl component of zeamide, oolong tea (C. sinensis), and P. sulcate extract.{40927,36634,36635} It has been used as a standard for the quantification of 15-methyl palmitic acid (Item No. 24814) in various foods.{40918} [Matreya, LLC. Catalog No. 1602]
Brand:CaymanSKU:24815 - 10 mgAvailable on backorder
15-methyl Palmitic acid methyl ester is a methylated fatty acid methyl ester that has been found in S. zeai sea sponges as the fatty acyl component of zeamide, oolong tea (C. sinensis), and P. sulcate extract.{40927,36634,36635} It has been used as a standard for the quantification of 15-methyl palmitic acid (Item No. 24814) in various foods.{40918} [Matreya, LLC. Catalog No. 1602]
Brand:CaymanSKU:24815 - 25 mgAvailable on backorder
15-methyl Palmitic acid methyl ester is a methylated fatty acid methyl ester that has been found in S. zeai sea sponges as the fatty acyl component of zeamide, oolong tea (C. sinensis), and P. sulcate extract.{40927,36634,36635} It has been used as a standard for the quantification of 15-methyl palmitic acid (Item No. 24814) in various foods.{40918} [Matreya, LLC. Catalog No. 1602]
Brand:CaymanSKU:24815 - 5 mgAvailable on backorder
15-methyl Palmitic acid methyl ester is a methylated fatty acid methyl ester that has been found in S. zeai sea sponges as the fatty acyl component of zeamide, oolong tea (C. sinensis), and P. sulcate extract.{40927,36634,36635} It has been used as a standard for the quantification of 15-methyl palmitic acid (Item No. 24814) in various foods.{40918} [Matreya, LLC. Catalog No. 1602]
Brand:CaymanSKU:24815 - 50 mgAvailable on backorder
15-OxoEDE is produced by the oxidation of 15-HEDE. 15-OxoEDE inhibits 5-LO from RBL-1 cells with an IC50 of 55 µM, which is about 2-fold lower than 15(S)-HEDE.{951} A related oxo-eicosanoid, 5-oxoETE, is biosynthesized from 5(S)-HETE by a specific dehydrogenase and has potent inflammatory activity.{2090}
Brand:CaymanSKU:37730 - 100 µgAvailable on backorder
15-OxoEDE is produced by the oxidation of 15-HEDE. 15-OxoEDE inhibits 5-LO from RBL-1 cells with an IC50 of 55 µM, which is about 2-fold lower than 15(S)-HEDE.{951} A related oxo-eicosanoid, 5-oxoETE, is biosynthesized from 5(S)-HETE by a specific dehydrogenase and has potent inflammatory activity.{2090}
Brand:CaymanSKU:37730 - 25 µgAvailable on backorder
15-OxoEDE is produced by the oxidation of 15-HEDE. 15-OxoEDE inhibits 5-LO from RBL-1 cells with an IC50 of 55 µM, which is about 2-fold lower than 15(S)-HEDE.{951} A related oxo-eicosanoid, 5-oxoETE, is biosynthesized from 5(S)-HETE by a specific dehydrogenase and has potent inflammatory activity.{2090}
Brand:CaymanSKU:37730 - 250 µgAvailable on backorder
15-OxoEDE is produced by the oxidation of 15-HEDE. 15-OxoEDE inhibits 5-LO from RBL-1 cells with an IC50 of 55 µM, which is about 2-fold lower than 15(S)-HEDE.{951} A related oxo-eicosanoid, 5-oxoETE, is biosynthesized from 5(S)-HETE by a specific dehydrogenase and has potent inflammatory activity.{2090}
Brand:CaymanSKU:37730 - 50 µgAvailable on backorder
15-OxoETE is produced by oxidation of the 15-hydroxyl of 15-HETE.{2793} Whether this is a major pathway of 15-HETE metabolism is yet to be clearly established.
Brand:CaymanSKU:34730 - 100 µgAvailable on backorder
15-OxoETE is produced by oxidation of the 15-hydroxyl of 15-HETE.{2793} Whether this is a major pathway of 15-HETE metabolism is yet to be clearly established.
Brand:CaymanSKU:34730 - 25 µgAvailable on backorder
15-OxoETE is produced by oxidation of the 15-hydroxyl of 15-HETE.{2793} Whether this is a major pathway of 15-HETE metabolism is yet to be clearly established.
Brand:CaymanSKU:34730 - 250 µgAvailable on backorder
15-OxoETE is produced by oxidation of the 15-hydroxyl of 15-HETE.{2793} Whether this is a major pathway of 15-HETE metabolism is yet to be clearly established.
Brand:CaymanSKU:34730 - 50 µgAvailable on backorder
15,16-Dihydrotanshinone I (DHTS) is a diterpene tanshinone that has been found in the roots of S. miltiorrhiza with diverse biological activities.{39842} DHTS inhibits RHL-2H3 mast cell degranulation with an IC50 value of 14.3 μM and reduces the tyrosine phosphorylation of phospholipase Cγ2 (PLCγ2) and ERK.{39843} It prevents HuR binding to RNA in a cell-free assay (Ki = 3.74 nM) and inhibits the production of TNF mRNA and protein in MCF-7 cells.{39842} DHTS reduces the viability of MCF-7, MDA-MB-231, and SK-BR-3 breast cancer cells with IC50 values of 0.84, 0.92, and 1.2 μM, respectively. It also reduces collagen-induced aggregation of washed rabbit platelets (IC50 = 8.7 μM).{39844} In vivo, DHTS (25 mg/kg per day) reduces tumor growth in an HL-60 leukemia mouse xenograft model by 68% relative to control without decreasing body weight.{39845} In mice with scopolamine-induced learning and memory impairment, DHTS (2-4 mg/kg, p.o.) increases latency to step-through in a passive avoidance test by approximately 3- to 4-fold, and it inhibits acetylcholinesterase in brain homogenate (IC50 = 25 μM).{39846}
Brand:CaymanSKU:25051 - 10 mgAvailable on backorder
15,16-Dihydrotanshinone I (DHTS) is a diterpene tanshinone that has been found in the roots of S. miltiorrhiza with diverse biological activities.{39842} DHTS inhibits RHL-2H3 mast cell degranulation with an IC50 value of 14.3 μM and reduces the tyrosine phosphorylation of phospholipase Cγ2 (PLCγ2) and ERK.{39843} It prevents HuR binding to RNA in a cell-free assay (Ki = 3.74 nM) and inhibits the production of TNF mRNA and protein in MCF-7 cells.{39842} DHTS reduces the viability of MCF-7, MDA-MB-231, and SK-BR-3 breast cancer cells with IC50 values of 0.84, 0.92, and 1.2 μM, respectively. It also reduces collagen-induced aggregation of washed rabbit platelets (IC50 = 8.7 μM).{39844} In vivo, DHTS (25 mg/kg per day) reduces tumor growth in an HL-60 leukemia mouse xenograft model by 68% relative to control without decreasing body weight.{39845} In mice with scopolamine-induced learning and memory impairment, DHTS (2-4 mg/kg, p.o.) increases latency to step-through in a passive avoidance test by approximately 3- to 4-fold, and it inhibits acetylcholinesterase in brain homogenate (IC50 = 25 μM).{39846}
Brand:CaymanSKU:25051 - 25 mgAvailable on backorder
15,16-Dihydrotanshinone I (DHTS) is a diterpene tanshinone that has been found in the roots of S. miltiorrhiza with diverse biological activities.{39842} DHTS inhibits RHL-2H3 mast cell degranulation with an IC50 value of 14.3 μM and reduces the tyrosine phosphorylation of phospholipase Cγ2 (PLCγ2) and ERK.{39843} It prevents HuR binding to RNA in a cell-free assay (Ki = 3.74 nM) and inhibits the production of TNF mRNA and protein in MCF-7 cells.{39842} DHTS reduces the viability of MCF-7, MDA-MB-231, and SK-BR-3 breast cancer cells with IC50 values of 0.84, 0.92, and 1.2 μM, respectively. It also reduces collagen-induced aggregation of washed rabbit platelets (IC50 = 8.7 μM).{39844} In vivo, DHTS (25 mg/kg per day) reduces tumor growth in an HL-60 leukemia mouse xenograft model by 68% relative to control without decreasing body weight.{39845} In mice with scopolamine-induced learning and memory impairment, DHTS (2-4 mg/kg, p.o.) increases latency to step-through in a passive avoidance test by approximately 3- to 4-fold, and it inhibits acetylcholinesterase in brain homogenate (IC50 = 25 μM).{39846}
Brand:CaymanSKU:25051 - 5 mgAvailable on backorder
15,16-Dihydrotanshinone I (DHTS) is a diterpene tanshinone that has been found in the roots of S. miltiorrhiza with diverse biological activities.{39842} DHTS inhibits RHL-2H3 mast cell degranulation with an IC50 value of 14.3 μM and reduces the tyrosine phosphorylation of phospholipase Cγ2 (PLCγ2) and ERK.{39843} It prevents HuR binding to RNA in a cell-free assay (Ki = 3.74 nM) and inhibits the production of TNF mRNA and protein in MCF-7 cells.{39842} DHTS reduces the viability of MCF-7, MDA-MB-231, and SK-BR-3 breast cancer cells with IC50 values of 0.84, 0.92, and 1.2 μM, respectively. It also reduces collagen-induced aggregation of washed rabbit platelets (IC50 = 8.7 μM).{39844} In vivo, DHTS (25 mg/kg per day) reduces tumor growth in an HL-60 leukemia mouse xenograft model by 68% relative to control without decreasing body weight.{39845} In mice with scopolamine-induced learning and memory impairment, DHTS (2-4 mg/kg, p.o.) increases latency to step-through in a passive avoidance test by approximately 3- to 4-fold, and it inhibits acetylcholinesterase in brain homogenate (IC50 = 25 μM).{39846}
Brand:CaymanSKU:25051 - 50 mgAvailable on backorder
Arbaprostil (15(R)-15-methyl prostaglandin E2) is a synthetic prostaglandin E2 (PGE2) analog developed for its cytoprotective activity.{2958} 15(R)-15-methyl Prostaglandin A2 (15(R)-15-methyl PGA2) is one of several impurities which are possible in the production of commercial lots of bulk arbaprostil.{2016} The pharmacology and EP receptor binding affinity for 15(R)-15-methyl PGA2 has not been published.
Brand:CaymanSKU:10270 - 1 mgAvailable on backorder
Arbaprostil (15(R)-15-methyl prostaglandin E2) is a synthetic prostaglandin E2 (PGE2) analog developed for its cytoprotective activity.{2958} 15(R)-15-methyl Prostaglandin A2 (15(R)-15-methyl PGA2) is one of several impurities which are possible in the production of commercial lots of bulk arbaprostil.{2016} The pharmacology and EP receptor binding affinity for 15(R)-15-methyl PGA2 has not been published.
Brand:CaymanSKU:10270 - 10 mgAvailable on backorder
Arbaprostil (15(R)-15-methyl prostaglandin E2) is a synthetic prostaglandin E2 (PGE2) analog developed for its cytoprotective activity.{2958} 15(R)-15-methyl Prostaglandin A2 (15(R)-15-methyl PGA2) is one of several impurities which are possible in the production of commercial lots of bulk arbaprostil.{2016} The pharmacology and EP receptor binding affinity for 15(R)-15-methyl PGA2 has not been published.
Brand:CaymanSKU:10270 - 5 mgAvailable on backorder
15(R)-15-methyl Prostaglandin D2 (15(R)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2 (Item No. 12010). The physiological actions of PGD2 include regulation of sleep, lowering of body temperature, inhibition of platelet aggregation and relaxation of vascular smooth muscle.{328,1185,580} PGD2 mediates its effects by 2 distinct G-protein-coupled receptors, DP1{3128} and CRTH2/DP2.{10722,9769} 15(R)-15-methyl PGD2 is a potent, selective agonist for the CRTH2/DP2 receptor.{10723} The EC50 values for eosinophil CD11b expression, actin polymerization, and chemotaxis are 1.4, 3.8, and 1.7 nM, respectively, each of which is approximately 3-5 fold lower than those for PGD2. In contrast the EC50 for the DP1-mediated increase in platelet cAMP by 15(R)-15-methyl PGD2 is >10 µM.{10723}
Brand:CaymanSKU:12720 - 1 mgAvailable on backorder
15(R)-15-methyl Prostaglandin D2 (15(R)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2 (Item No. 12010). The physiological actions of PGD2 include regulation of sleep, lowering of body temperature, inhibition of platelet aggregation and relaxation of vascular smooth muscle.{328,1185,580} PGD2 mediates its effects by 2 distinct G-protein-coupled receptors, DP1{3128} and CRTH2/DP2.{10722,9769} 15(R)-15-methyl PGD2 is a potent, selective agonist for the CRTH2/DP2 receptor.{10723} The EC50 values for eosinophil CD11b expression, actin polymerization, and chemotaxis are 1.4, 3.8, and 1.7 nM, respectively, each of which is approximately 3-5 fold lower than those for PGD2. In contrast the EC50 for the DP1-mediated increase in platelet cAMP by 15(R)-15-methyl PGD2 is >10 µM.{10723}
Brand:CaymanSKU:12720 - 5 mgAvailable on backorder
15(R)-15-methyl Prostaglandin D2 (15(R)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2 (Item No. 12010). The physiological actions of PGD2 include regulation of sleep, lowering of body temperature, inhibition of platelet aggregation and relaxation of vascular smooth muscle.{328,1185,580} PGD2 mediates its effects by 2 distinct G-protein-coupled receptors, DP1{3128} and CRTH2/DP2.{10722,9769} 15(R)-15-methyl PGD2 is a potent, selective agonist for the CRTH2/DP2 receptor.{10723} The EC50 values for eosinophil CD11b expression, actin polymerization, and chemotaxis are 1.4, 3.8, and 1.7 nM, respectively, each of which is approximately 3-5 fold lower than those for PGD2. In contrast the EC50 for the DP1-mediated increase in platelet cAMP by 15(R)-15-methyl PGD2 is >10 µM.{10723}
Brand:CaymanSKU:12720 - 500 µgAvailable on backorder
15(R)-15-methyl Prostaglandin E2 (15(R)-15-methyl PGE2) is a prodrug for the potent PGE2 (Item No. 14010) analog 15(S)-15-methyl PGE2 (Item No. 14730).{1994} Acid-catalyzed epimerization in the stomach produces the 15(S)-hydroxy compound which is biologically active.{1150} Oral administration of 15(R)-15-methyl PGE2 to dogs or rats at 10-300 µg/kg results in a dose-dependent inhibition of gastric acid secretion and an increase in the rate of duodenal bicarbonate secretion.{1151,1152}
Brand:CaymanSKU:- 15(R)-15-methyl Prostaglandin E2 (15(R)-15-methyl PGE2) is a prodrug for the potent PGE2 (Item No. 14010) analog 15(S)-15-methyl PGE2 (Item No. 14730).{1994} Acid-catalyzed epimerization in the stomach produces the 15(S)-hydroxy compound which is biologically active.{1150} Oral administration of 15(R)-15-methyl PGE2 to dogs or rats at 10-300 µg/kg results in a dose-dependent inhibition of gastric acid secretion and an increase in the rate of duodenal bicarbonate secretion.{1151,1152}
Brand:CaymanSKU:-
15(R)-15-methyl PGF2α is a metabolically stable analog of PGF2α. 15(R)-15-methyl PGF2α is an inactive, prodrug PGF agonist designed for activation by gastric acid after oral administration. Acid-catalyzed epimerization of 15(R)-15-methyl PGF2α converts it into the active 15(S)-isomer.{4631,1989} The 15(S)-isomer induces luteolysis when injected in rhesus monkeys at a dose of about 12 mg/animal, while the 15(R)-isomer does not.{4632}
Brand:CaymanSKU:-Out of stock
15(R)-15-methyl PGF2α is a metabolically stable analog of PGF2α. 15(R)-15-methyl PGF2α is an inactive, prodrug PGF agonist designed for activation by gastric acid after oral administration. Acid-catalyzed epimerization of 15(R)-15-methyl PGF2α converts it into the active 15(S)-isomer.{4631,1989} The 15(S)-isomer induces luteolysis when injected in rhesus monkeys at a dose of about 12 mg/animal, while the 15(R)-isomer does not.{4632}
Brand:CaymanSKU:-Out of stock
15(R)-15-methyl Prostaglandin F2α methyl ester (15(R)-15-methyl PGF2α methyl ester) is a lipid soluble prodrug form of 15(R)-15-methyl PGF2α (Item No. 16730) with increased membrane permeability. Acid-catalyzed epimerization of 15(R)-15-methyl PGF2α methyl ester and hydrolysis of the ester converts it into the active 15(S)-15-methyl PGF2α (Item No. 16743).{4631,1989}
Brand:CaymanSKU:-Out of stock
15(R)-15-methyl Prostaglandin F2α methyl ester (15(R)-15-methyl PGF2α methyl ester) is a lipid soluble prodrug form of 15(R)-15-methyl PGF2α (Item No. 16730) with increased membrane permeability. Acid-catalyzed epimerization of 15(R)-15-methyl PGF2α methyl ester and hydrolysis of the ester converts it into the active 15(S)-15-methyl PGF2α (Item No. 16743).{4631,1989}
Brand:CaymanSKU:-Out of stock