Description
Two types of 15-LO have been discovered and characterized, both of which metabolize arachidonic acid (AA) to produce 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE). 15-LO-1 oxygenates AA at both C15 and C12,{11792} whereas 15-LO-2 exclusively oxygenates C15 of AA.{4675} Human 15-LO-2 has a molecular mass of approximately 76 kDa and exhibits approximately 40% identity to the reticulocyte 15-LO-1.{4675,11789} Expression of 15-LO-2 appears to be restricted to prostate, lung, skin, and cornea and may play a role in the normal development of these tissues.{11790} The protein levels and enzymatic activity of 15-LO-2 are both down-regulated in prostate cancer compared with normal and benign prostate tissues, implicating a possible protective role for 15-LO-2 against tumor formation.{11790,8774,9075} Cayman Chemical’s 15-LO-2 polyclonal antibody can be used for western blot analysis for 15-LO-2 on samples of human origin. Other applications for use of this antibody have not yet been tested.
Synonyms: 15-LO-2|15-LOX-2|ALOX15B|Arachidonate 15-Lipoxygenase Type II|Arachidonate 15-lipoxygenase B|Linoleate 13-lipoxygenase 15-Lob
Immunogen: Synthetic peptide from the internal region of human 15-lipoxygenase-2
Formulation: 50-500 µg of peptide affinity-purified antibody
Isotype:
Applications: ICC, IHC, and WB
Origin: Animal/Rabbit
Stability: 365 days
Application|Immunocytochemistry||Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cancer||Research Area|Lipid Biochemistry|Lipoxygenase Pathways
