Cayman
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Fulvic acid is a phenolic acid and fungal metabolite originally isolated from Penicillium.{48057} Fulvic acids are formed via degradation of organisms and their wastes and are classified as humic substances, which are present in soil and water, can form complexes with metals, and can act as oxidizers or reducers.{48060,48061} Fulvic acid is predicted to inhibit amyloid-β (17-42) (Aβ17-42) dimerization, disrupt preformed Aβ17-42 trimers, and bind to the catalytic site of phosphodiesterase 5A (PDE5A) based on molecular dynamics simulation studies.{48058,48059}
Brand:CaymanSKU:-Available on backorder
Fumagillin is an antibiotic derived from the fungus A. fumigatus. It binds and inhibits methionine aminopeptidase-2 with an IC50 value of 10 nM.{20540,20542} Fumagillin inhibits angiogenesis by impairing the growth of endothelial cells and altering gene expression.{20540,20543,20545} It also impairs microsporidial replication and can be used to treat both conjunctival and intestinal microsporidial infections in immunocompromised patients.{20539,20544} Finally, fumagillin reduces diet-induced adipose tissue formation in mice, independent of its effects on angiogenesis.{20541}
Brand:CaymanSKU:11332 - 1 mgAvailable on backorder
Fumagillin is an antibiotic derived from the fungus A. fumigatus. It binds and inhibits methionine aminopeptidase-2 with an IC50 value of 10 nM.{20540,20542} Fumagillin inhibits angiogenesis by impairing the growth of endothelial cells and altering gene expression.{20540,20543,20545} It also impairs microsporidial replication and can be used to treat both conjunctival and intestinal microsporidial infections in immunocompromised patients.{20539,20544} Finally, fumagillin reduces diet-induced adipose tissue formation in mice, independent of its effects on angiogenesis.{20541}
Brand:CaymanSKU:11332 - 10 mgAvailable on backorder
Fumagillin is an antibiotic derived from the fungus A. fumigatus. It binds and inhibits methionine aminopeptidase-2 with an IC50 value of 10 nM.{20540,20542} Fumagillin inhibits angiogenesis by impairing the growth of endothelial cells and altering gene expression.{20540,20543,20545} It also impairs microsporidial replication and can be used to treat both conjunctival and intestinal microsporidial infections in immunocompromised patients.{20539,20544} Finally, fumagillin reduces diet-induced adipose tissue formation in mice, independent of its effects on angiogenesis.{20541}
Brand:CaymanSKU:11332 - 5 mgAvailable on backorder
Fumiquinazoline D is a fungal metabolite originally isolated from A. fumigatus that has activity against Gram-positive and Gram-negative bacteria (MICs = 8-16 µg/ml) as well as F. solani and C. albicans fungi (MICs = 32 and 64 µg/ml, respectively).{35199,35200}
Brand:CaymanSKU:23848 - 1 mgAvailable on backorder
Fumiquinazoline D is a fungal metabolite originally isolated from A. fumigatus that has activity against Gram-positive and Gram-negative bacteria (MICs = 8-16 µg/ml) as well as F. solani and C. albicans fungi (MICs = 32 and 64 µg/ml, respectively).{35199,35200}
Brand:CaymanSKU:23848 - 5 mgAvailable on backorder
Fumitremorgin B is a mycotoxin originally isolated from A. fumigatus.{57187,57188} It induces tremors in and is lethal to mice (LD50 = 5.4 mg/kg, i.v.). It is also toxic to brine shrimp (LC50 = 13.6 μg/ml).{57189} Fumitremorgin B is active against the phytopathogenic fungi B. cinerea, A. solani, A. alternata, C. gloeosporioides, F. solani, F. oxysporum, and G. saubinettii (MICs = 6.25-100 μg/ml). It has antifeedant activity against armyworm (M. separata) larvae when applied to fresh wheat leaves. Fumitremorgin B inhibits the proliferation of U937 and PC3 cells (IC50s = 14.12 and 43.36 μM, respectively).{57190}
Brand:CaymanSKU:31173 - 1 mgAvailable on backorder
Fumitremorgin B is a mycotoxin originally isolated from A. fumigatus.{57187,57188} It induces tremors in and is lethal to mice (LD50 = 5.4 mg/kg, i.v.). It is also toxic to brine shrimp (LC50 = 13.6 μg/ml).{57189} Fumitremorgin B is active against the phytopathogenic fungi B. cinerea, A. solani, A. alternata, C. gloeosporioides, F. solani, F. oxysporum, and G. saubinettii (MICs = 6.25-100 μg/ml). It has antifeedant activity against armyworm (M. separata) larvae when applied to fresh wheat leaves. Fumitremorgin B inhibits the proliferation of U937 and PC3 cells (IC50s = 14.12 and 43.36 μM, respectively).{57190}
Brand:CaymanSKU:31173 - 5 mgAvailable on backorder
Fumitremorgin C is a specific inhibitor of breast cancer resistance protein (BCRP/ABCG2) multidrug efflux transporter. At 5 μM, it significantly potentiates the toxicity of the chemotherapeutic drugs mitoxantrone, doxorubicin, and topotecan in S1-M1-3.2 colon carcinoma cells.{20755} Fumitremorgin C reverses multidrug resistance in cells overexpressing BCRP but not P-glycoprotein (ABCB1) or MRP1 (ABCC1).{20754,20756}
Brand:CaymanSKU:11030 - 1 mgAvailable on backorder
Fumitremorgin C is a specific inhibitor of breast cancer resistance protein (BCRP/ABCG2) multidrug efflux transporter. At 5 μM, it significantly potentiates the toxicity of the chemotherapeutic drugs mitoxantrone, doxorubicin, and topotecan in S1-M1-3.2 colon carcinoma cells.{20755} Fumitremorgin C reverses multidrug resistance in cells overexpressing BCRP but not P-glycoprotein (ABCB1) or MRP1 (ABCC1).{20754,20756}
Brand:CaymanSKU:11030 - 250 µgAvailable on backorder
Fumonisin B1 is a mycotoxin produced from F. moniliforme, a prevalent fungus of corn and other grains. Outbreaks of food poisoning in livestock and humans following the consumption of Fusarium infested corn are caused by fumonisins.{1632} It functions as an inhibitor of ceramide synthase (sphingosine N-acyltransferase).{5545} Fumonisin B1 attenuates the response of P388D1 cells to PAF and LPS by inhibiting ceramide formation.{4947} It also blocks the apoptotic response of HaCaT cells to the antiproliferative drug hexadecylphosphocholine, again through inhibition of ceramide production.{6525} Incubation of Swiss 3T3 cells with fumonisin B1 results in both an altered cell morphology due to disruption of axonal growth and a decrease in cell proliferation.{5180}
Brand:CaymanSKU:62580 - 1 mgAvailable on backorder
Fumonisin B1 is a mycotoxin produced from F. moniliforme, a prevalent fungus of corn and other grains. Outbreaks of food poisoning in livestock and humans following the consumption of Fusarium infested corn are caused by fumonisins.{1632} It functions as an inhibitor of ceramide synthase (sphingosine N-acyltransferase).{5545} Fumonisin B1 attenuates the response of P388D1 cells to PAF and LPS by inhibiting ceramide formation.{4947} It also blocks the apoptotic response of HaCaT cells to the antiproliferative drug hexadecylphosphocholine, again through inhibition of ceramide production.{6525} Incubation of Swiss 3T3 cells with fumonisin B1 results in both an altered cell morphology due to disruption of axonal growth and a decrease in cell proliferation.{5180}
Brand:CaymanSKU:62580 - 10 mgAvailable on backorder
Fumonisin B1 is a mycotoxin produced from F. moniliforme, a prevalent fungus of corn and other grains. Outbreaks of food poisoning in livestock and humans following the consumption of Fusarium infested corn are caused by fumonisins.{1632} It functions as an inhibitor of ceramide synthase (sphingosine N-acyltransferase).{5545} Fumonisin B1 attenuates the response of P388D1 cells to PAF and LPS by inhibiting ceramide formation.{4947} It also blocks the apoptotic response of HaCaT cells to the antiproliferative drug hexadecylphosphocholine, again through inhibition of ceramide production.{6525} Incubation of Swiss 3T3 cells with fumonisin B1 results in both an altered cell morphology due to disruption of axonal growth and a decrease in cell proliferation.{5180}
Brand:CaymanSKU:62580 - 5 mgAvailable on backorder
Fumonisin B2 (FB2) is a mycotoxin that has been found in F. moniliforme.{1632} It is cytotoxic against a panel of seven rat hepatoma cell lines (IC50s = 3-50 µg/ml), as well as MDCK cells (IC50 = 2 µg/ml).{59489} FB2 (125-1,000 µM) is also cytotoxic to primary rat hepatocytes and induces hepatocyte nodule formation, a marker of cancer initiation, in rats when administered at a dose of 1,000 mg/kg for 21 days.{61109} FB2 has been detected in corn and corn-based foods and livestock feeds.{61110}
Brand:CaymanSKU:- Fumonisin B2 (FB2) is a mycotoxin that has been found in F. moniliforme.{1632} It is cytotoxic against a panel of seven rat hepatoma cell lines (IC50s = 3-50 µg/ml), as well as MDCK cells (IC50 = 2 µg/ml).{59489} FB2 (125-1,000 µM) is also cytotoxic to primary rat hepatocytes and induces hepatocyte nodule formation, a marker of cancer initiation, in rats when administered at a dose of 1,000 mg/kg for 21 days.{61109} FB2 has been detected in corn and corn-based foods and livestock feeds.{61110}
Brand:CaymanSKU:- Fumonisin B2 (FB2) is a mycotoxin that has been found in F. moniliforme.{1632} It is cytotoxic against a panel of seven rat hepatoma cell lines (IC50s = 3-50 µg/ml), as well as MDCK cells (IC50 = 2 µg/ml).{59489} FB2 (125-1,000 µM) is also cytotoxic to primary rat hepatocytes and induces hepatocyte nodule formation, a marker of cancer initiation, in rats when administered at a dose of 1,000 mg/kg for 21 days.{61109} FB2 has been detected in corn and corn-based foods and livestock feeds.{61110}
Brand:CaymanSKU:- Fumonisin B2 (FB2) is a mycotoxin that has been found in F. moniliforme.{1632} It is cytotoxic against a panel of seven rat hepatoma cell lines (IC50s = 3-50 µg/ml), as well as MDCK cells (IC50 = 2 µg/ml).{59489} FB2 (125-1,000 µM) is also cytotoxic to primary rat hepatocytes and induces hepatocyte nodule formation, a marker of cancer initiation, in rats when administered at a dose of 1,000 mg/kg for 21 days.{61109} FB2 has been detected in corn and corn-based foods and livestock feeds.{61110}
Brand:CaymanSKU:-
Fumonisin B2-13C34 (FB2-13C34) is intended for use as an internal standard for the quantification of FB2 (Item No. 13227) by GC- or LC-MS. FB2 is a mycotoxin that has been found in F. moniliforme.{1632} It is cytotoxic against a panel of seven rat hepatoma cell lines (IC50s = 3-50 µg/ml), as well as MDCK cells (IC50 = 2 µg/ml).{59489} FB2 (125-1,000 µM) is also cytotoxic to primary rat hepatocytes and induces hepatocyte nodule formation, a marker of cancer initiation, in rats when administered at a dose of 1,000 mg/kg for 21 days.{61109} FB2 has been detected in corn and corn-based foods and livestock feeds.{61110}
Brand:CaymanSKU:31273 - 1.2 mlAvailable on backorder
Fumonisin B3 (FB3) is a mycotoxin that has been found in Fusarium.{61108} It is cytotoxic to primary rat hepatocytes when used at concentrations of 125, 250, and 500 µM.{61109} Dietary administration of FB3 (0.05%) for 14 or 21 days induces hepatocyte nodules, a marker of cancer initiation, in rats. FB3 has been detected in corn and corn-based foods and livestock feeds.{61110}
Brand:CaymanSKU:20434 -Available on backorder
Funalenone is a phenalenone originally isolated from A. niger.{41696} It inhibits HIV-1 integrase (IC50 = 10 μM) and HIV-1 replication in human peripheral blood cells transformed by murine leukemia virus (HPB-M(a); IC50 = 1.7 μM) but is less cytotoxic to mammalian HPB-M(a) cells (IC50 = 87 μM).{41698} Funalenone selectively inhibits matrix metalloproteinase-1 (MMP-1; IC50 = 170 μM) over MMP-2 and MMP-9, which it inhibits by 18.3 and 38.2%, respectively, when used at a concentration of 400 μM.{41696} It also inhibits the bacterial cell wall synthesis enzymes MraY and MurG (IC50s = 25.5 μM in a membrane plate assay) and inhibits growth of S. aureus with a MIC value of 64 μg/mL.{41697}
Brand:CaymanSKU:23491 - 1 mgAvailable on backorder
Funalenone is a phenalenone originally isolated from A. niger.{41696} It inhibits HIV-1 integrase (IC50 = 10 μM) and HIV-1 replication in human peripheral blood cells transformed by murine leukemia virus (HPB-M(a); IC50 = 1.7 μM) but is less cytotoxic to mammalian HPB-M(a) cells (IC50 = 87 μM).{41698} Funalenone selectively inhibits matrix metalloproteinase-1 (MMP-1; IC50 = 170 μM) over MMP-2 and MMP-9, which it inhibits by 18.3 and 38.2%, respectively, when used at a concentration of 400 μM.{41696} It also inhibits the bacterial cell wall synthesis enzymes MraY and MurG (IC50s = 25.5 μM in a membrane plate assay) and inhibits growth of S. aureus with a MIC value of 64 μg/mL.{41697}
Brand:CaymanSKU:23491 - 2.5 mgAvailable on backorder
Funalenone is a phenalenone originally isolated from A. niger.{41696} It inhibits HIV-1 integrase (IC50 = 10 μM) and HIV-1 replication in human peripheral blood cells transformed by murine leukemia virus (HPB-M(a); IC50 = 1.7 μM) but is less cytotoxic to mammalian HPB-M(a) cells (IC50 = 87 μM).{41698} Funalenone selectively inhibits matrix metalloproteinase-1 (MMP-1; IC50 = 170 μM) over MMP-2 and MMP-9, which it inhibits by 18.3 and 38.2%, respectively, when used at a concentration of 400 μM.{41696} It also inhibits the bacterial cell wall synthesis enzymes MraY and MurG (IC50s = 25.5 μM in a membrane plate assay) and inhibits growth of S. aureus with a MIC value of 64 μg/mL.{41697}
Brand:CaymanSKU:23491 - 500 µgAvailable on backorder
Fura-2 is a ratiometric fluorescent calcium indicator that can be used to detect calcium in cells.{40992} It is a pentacarboxylate that displays excitation maxima of 340 and 380 nm at high and low calcium concentrations, respectively, when the emission is fixed at 510 nm, enabling determination of ratiometric measurements of calcium influx in live cells.
Brand:CaymanSKU:-Available on backorder
Fura-2 is a ratiometric fluorescent calcium indicator that can be used to detect calcium in cells.{40992} It is a pentacarboxylate that displays excitation maxima of 340 and 380 nm at high and low calcium concentrations, respectively, when the emission is fixed at 510 nm, enabling determination of ratiometric measurements of calcium influx in live cells.
Brand:CaymanSKU:-Available on backorder
Fura-2 is a ratiometric fluorescent calcium indicator that can be used to detect calcium in cells.{40992} It is a pentacarboxylate that displays excitation maxima of 340 and 380 nm at high and low calcium concentrations, respectively, when the emission is fixed at 510 nm, enabling determination of ratiometric measurements of calcium influx in live cells.
Brand:CaymanSKU:-Available on backorder
Fura-2 AM is a membrane permeable, UV light-excitable form of Fura-2 (Item Nos. 19531 | 20414).{22804} It crosses cell membranes and is converted to Fura-2 via cellular esterases.{23059} Fura-2 is a ratiometric fluorescent calcium indicator that can be used to detect calcium in cells.{40992} It is a pentacarboxylate that displays excitation maxima of 340 and 380 nm at high and low calcium concentrations, respectively, when the emission is fixed at 510 nm, enabling determination of ratiometric measurements of calcium influx in live cells.
Brand:CaymanSKU:-
Fura-FF is a difluorinated derivative of the calcium indicator fura-2 (Item Nos. 19531 | 20414). Unlike, fura-2, fura-FF has negligible magnesium sensitivity, thus reducing interference from this cation.{38261} Fura-FF also has a higher calcium dissociation constant than fura-2 (Kd(calcium) = 6 and 0.14 µM, respectively).{38261,23059} However, the spectral properties of fura-FF and fura-2 are similar with fura-FF displaying excitation/emission spectra of 365/514 nm in the absence of calcium, with a shift to 339/507 nm in the presence of a high calcium concentration.{38262} Low affinity calcium dyes, including fura-FF, are preferred for studying compartments with high concentrations of calcium, such as mitochondria, or in cell systems that have relatively low calcium buffering capacities, such as neuronal dendrites and spines.{31952,31953,31954}
Brand:CaymanSKU:20415 -Available on backorder
Fura-FF AM is a cell-permeable acetoxymethyl ester of the fluorescence calcium indicator fura-FF (potassium salt) (Item No. 20415). As fura-FF AM enters cells, it is hydrolyzed by intracellular esterases to produce fura-FF. Fura-FF is a difluorinated derivative of the calcium indicator fura-2 (Item Nos. 19531 | 20414). Unlike, fura-2, fura-FF has negligible magnesium sensitivity, thus reducing interference from this cation.{38261} Fura-FF also has a higher calcium dissociation constant than fura-2 (Kd(calcium) = 6 and 0.14 µM, respectively).{38261,23059} However, the spectral properties of fura-FF and fura-2 are similar with fura-FF displaying excitation/emission spectra of 365/514 nm in the absence of calcium, with a shift to 339/507 nm in the presence of a high calcium concentration.{38262} Low affinity calcium dyes, including fura-FF, are preferred for studying compartments with high concentrations of calcium, such as mitochondria, or in cell systems that have relatively low calcium buffering capacities, such as neuronal dendrites and spines.{31952,31953,31954}
Brand:CaymanSKU:20416 -Available on backorder
Furafylline is a selective inhibitor of human cytochrome P450 (CYP)1A2 (IC50 = 0.07 µM), demonstrating little effect on other CYP isoforms including 2D1, 2C, 3A, or 1A1.{25943} It was originally introduced as a bronchodilator with extended duration compared to theophylline, but then subsequently reported to inhibit the oxidation of caffeine (Item No. 14118), a reaction catalyzed by CYP1A2.{25943,25942}
Brand:CaymanSKU:9000058 - 1 mgAvailable on backorder
Furafylline is a selective inhibitor of human cytochrome P450 (CYP)1A2 (IC50 = 0.07 µM), demonstrating little effect on other CYP isoforms including 2D1, 2C, 3A, or 1A1.{25943} It was originally introduced as a bronchodilator with extended duration compared to theophylline, but then subsequently reported to inhibit the oxidation of caffeine (Item No. 14118), a reaction catalyzed by CYP1A2.{25943,25942}
Brand:CaymanSKU:9000058 - 5 mgAvailable on backorder
Furafylline is a selective inhibitor of human cytochrome P450 (CYP)1A2 (IC50 = 0.07 µM), demonstrating little effect on other CYP isoforms including 2D1, 2C, 3A, or 1A1.{25943} It was originally introduced as a bronchodilator with extended duration compared to theophylline, but then subsequently reported to inhibit the oxidation of caffeine (Item No. 14118), a reaction catalyzed by CYP1A2.{25943,25942}
Brand:CaymanSKU:9000058 - 500 µgAvailable on backorder
Furamidine is a cell-permeable inhibitor of protein arginine methyltransferase 1 (PRMT1) that is selective for PRMT1 over PRMT5, PRMT6, and PRMT4/coactivator-associated arginine methyltransferase 1 (CARM1) (IC50s = 9.4, 166, 283, and >400 μM, respectively).{38288} In vitro, furamidine (20 μM) inhibits Aly protein methylation in HEK293T cells and growth of several leukemia cell lines. It inhibits tyrosyl-DNA phosphodiesterase (Tdp1) activity on both single- and double-stranded DNA substrates with concentrations in the low micromolar range, but it is more potent against a duplex DNA substrate.{38289} Furamidine inhibits growth of T. brucei, the parasite that causes sleeping sickness, with IC50 values of 1.5 to 37 nM across various strains.{38290} It inhibits the T. brucei P2 aminopurine transporter (Ki = 1.2 μM).{38290} It also binds to AT-rich DNA sequences in trypanosome kinetoplast DNA.{38292,38293,38291}
Brand:CaymanSKU:-Available on backorder
Furamidine is a cell-permeable inhibitor of protein arginine methyltransferase 1 (PRMT1) that is selective for PRMT1 over PRMT5, PRMT6, and PRMT4/coactivator-associated arginine methyltransferase 1 (CARM1) (IC50s = 9.4, 166, 283, and >400 μM, respectively).{38288} In vitro, furamidine (20 μM) inhibits Aly protein methylation in HEK293T cells and growth of several leukemia cell lines. It inhibits tyrosyl-DNA phosphodiesterase (Tdp1) activity on both single- and double-stranded DNA substrates with concentrations in the low micromolar range, but it is more potent against a duplex DNA substrate.{38289} Furamidine inhibits growth of T. brucei, the parasite that causes sleeping sickness, with IC50 values of 1.5 to 37 nM across various strains.{38290} It inhibits the T. brucei P2 aminopurine transporter (Ki = 1.2 μM).{38290} It also binds to AT-rich DNA sequences in trypanosome kinetoplast DNA.{38292,38293,38291}
Brand:CaymanSKU:-Available on backorder
Furamidine is a cell-permeable inhibitor of protein arginine methyltransferase 1 (PRMT1) that is selective for PRMT1 over PRMT5, PRMT6, and PRMT4/coactivator-associated arginine methyltransferase 1 (CARM1) (IC50s = 9.4, 166, 283, and >400 μM, respectively).{38288} In vitro, furamidine (20 μM) inhibits Aly protein methylation in HEK293T cells and growth of several leukemia cell lines. It inhibits tyrosyl-DNA phosphodiesterase (Tdp1) activity on both single- and double-stranded DNA substrates with concentrations in the low micromolar range, but it is more potent against a duplex DNA substrate.{38289} Furamidine inhibits growth of T. brucei, the parasite that causes sleeping sickness, with IC50 values of 1.5 to 37 nM across various strains.{38290} It inhibits the T. brucei P2 aminopurine transporter (Ki = 1.2 μM).{38290} It also binds to AT-rich DNA sequences in trypanosome kinetoplast DNA.{38292,38293,38291}
Brand:CaymanSKU:-Available on backorder
Furan fatty acid F5 is a furan fatty acid originally isolated from northern pike (E. lucius).{38341} Levels of furan fatty acid F5 are increased in the liver of starving cod.{43352}
Brand:CaymanSKU:25862 - 1 mgAvailable on backorder
Furan fatty acid F5 is a furan fatty acid originally isolated from northern pike (E. lucius).{38341} Levels of furan fatty acid F5 are increased in the liver of starving cod.{43352}
Brand:CaymanSKU:25862 - 5 mgAvailable on backorder
Furan fatty acid F6 is a furan fatty acid originally isolated from E. lucius (Northern pike).{38340,38341} Furan fatty acid F6 pre-treatment prevents cell death from hydrogen peroxide-induced oxidative stress in rat brain C6 astroglioma cells in a dose-dependent manner.{38342}
Brand:CaymanSKU:9003082 - 1 mgAvailable on backorder
Furan fatty acid F6 is a furan fatty acid originally isolated from E. lucius (Northern pike).{38340,38341} Furan fatty acid F6 pre-treatment prevents cell death from hydrogen peroxide-induced oxidative stress in rat brain C6 astroglioma cells in a dose-dependent manner.{38342}
Brand:CaymanSKU:9003082 - 10 mgAvailable on backorder
Furan fatty acid F6 is a furan fatty acid originally isolated from E. lucius (Northern pike).{38340,38341} Furan fatty acid F6 pre-treatment prevents cell death from hydrogen peroxide-induced oxidative stress in rat brain C6 astroglioma cells in a dose-dependent manner.{38342}
Brand:CaymanSKU:9003082 - 5 mgAvailable on backorder
Furegrelate is a potent inhibitor of thromboxane synthase with little effect on other enzymes essential for arachidonate metabolism. The IC50 value is 15 nM for human platelet microsomal thromboxane synthase.{1227,1228}
Brand:CaymanSKU:70540 - 10 mgAvailable on backorder
Furegrelate is a potent inhibitor of thromboxane synthase with little effect on other enzymes essential for arachidonate metabolism. The IC50 value is 15 nM for human platelet microsomal thromboxane synthase.{1227,1228}
Brand:CaymanSKU:70540 - 5 mgAvailable on backorder
Furegrelate is a potent inhibitor of thromboxane synthase with little effect on other enzymes essential for arachidonate metabolism. The IC50 value is 15 nM for human platelet microsomal thromboxane synthase.{1227,1228}
Brand:CaymanSKU:70540 - 50 mgAvailable on backorder
Furin is a proprotein convertase, converting precursor proteins to functional proteins within the Golgi/trans-Golgi secretory pathway. Furin inhibitor I is a selective, irreversible, and cell-permeable competitive inhibitor of proprotein convertases, including furin/SPC1 (Ki = ~1 nM), SPC2/PC2 (Ki = 0.36 nM), SPC3/PC1/PC3 (Ki = 2.0 nM), SPC4/PACE4 (Ki = 3.6 nM), SPC6/PC5/PC6, and SPC7/LPC/PC7/PC8 (Ki = 0.12 nM).{24090,24089} Because furin activates viral glycoproteins, this inhibitor is a useful antiviral agent.{24087} In addition, it inhibits furin-dependent pro-MMP-2 activation in mononuclear inflammatory cells.{24088}
Brand:CaymanSKU:- Furin is a proprotein convertase, converting precursor proteins to functional proteins within the Golgi/trans-Golgi secretory pathway. Furin inhibitor I is a selective, irreversible, and cell-permeable competitive inhibitor of proprotein convertases, including furin/SPC1 (Ki = ~1 nM), SPC2/PC2 (Ki = 0.36 nM), SPC3/PC1/PC3 (Ki = 2.0 nM), SPC4/PACE4 (Ki = 3.6 nM), SPC6/PC5/PC6, and SPC7/LPC/PC7/PC8 (Ki = 0.12 nM).{24090,24089} Because furin activates viral glycoproteins, this inhibitor is a useful antiviral agent.{24087} In addition, it inhibits furin-dependent pro-MMP-2 activation in mononuclear inflammatory cells.{24088}
Brand:CaymanSKU:- Furin is a proprotein convertase, converting precursor proteins to functional proteins within the Golgi/trans-Golgi secretory pathway. Furin inhibitor I is a selective, irreversible, and cell-permeable competitive inhibitor of proprotein convertases, including furin/SPC1 (Ki = ~1 nM), SPC2/PC2 (Ki = 0.36 nM), SPC3/PC1/PC3 (Ki = 2.0 nM), SPC4/PACE4 (Ki = 3.6 nM), SPC6/PC5/PC6, and SPC7/LPC/PC7/PC8 (Ki = 0.12 nM).{24090,24089} Because furin activates viral glycoproteins, this inhibitor is a useful antiviral agent.{24087} In addition, it inhibits furin-dependent pro-MMP-2 activation in mononuclear inflammatory cells.{24088}
Brand:CaymanSKU:-
Furosemide is a loop diuretic and an inhibitor of the Na+/K+/2Cl- (NKCC) cotransporters, NKCC1 and NKCC2 (Kis = ~10 µM for both).{23244,28297} In vivo, furosemide (0.1 mg/kg, p.o.) increases diuresis in beagle dogs.{52809} Furosemide (30 mg/kg) reduces ventricular collagen deposition and fibrosis in a rat model of dilated cardiomyopathy.{52810} It is also an inhibitor of carbonic anhydrase I (CAI), CAII, and CAIII (Kis = 0.052-0.065 µM) and organic ion transporter 1 (OAT1; Ki = 9.5 µM), as well as a GABAA receptor antagonist.{23242,29296,29298} This product is also available as an analytical reference standard (Item No. 26298).
Brand:CaymanSKU:-Available on backorder
Furosemide (Item No. 26298) is an analytical reference standard categorized as a diuretic.{33139} Formulations containing diuretics, including furosemide, have been misused in sports for weight reduction and as masking agents in humans and to prevent exercise-induced pulmonary hemorrhage in racehorses.{33139,46102} This product is intended for use in analytical forensic applications. This product is also available as a general research tool (Item No. 17273).
Brand:CaymanSKU:26298 - 1 mgAvailable on backorder
Furosemide is a loop diuretic and an inhibitor of the Na+/K+/2Cl- (NKCC) cotransporters, NKCC1 and NKCC2 (Kis = ~10 µM for both).{23244,28297} In vivo, furosemide (0.1 mg/kg, p.o.) increases diuresis in beagle dogs.{52809} Furosemide (30 mg/kg) reduces ventricular collagen deposition and fibrosis in a rat model of dilated cardiomyopathy.{52810} It is also an inhibitor of carbonic anhydrase I (CAI), CAII, and CAIII (Kis = 0.052-0.065 µM) and organic ion transporter 1 (OAT1; Ki = 9.5 µM), as well as a GABAA receptor antagonist.{23242,29296,29298} This product is also available as an analytical reference standard (Item No. 26298).
Brand:CaymanSKU:-Available on backorder
Furosemide (Item No. 26298) is an analytical reference standard categorized as a diuretic.{33139} Formulations containing diuretics, including furosemide, have been misused in sports for weight reduction and as masking agents in humans and to prevent exercise-induced pulmonary hemorrhage in racehorses.{33139,46102} This product is intended for use in analytical forensic applications. This product is also available as a general research tool (Item No. 17273).
Brand:CaymanSKU:26298 - 5 mgAvailable on backorder
Furosemide-d5 is intended for use as an internal standard for the quantification of furosemide (Item No. 17273) by GC- or LC-MS. Furosemide is a loop diuretic and an inhibitor of the Na+/K+/2Cl- (NKCC) cotransporters, NKCC1 and NKCC2 (Kis = ~10 µM for both).{23244,28297} In vivo, furosemide (0.1 mg/kg, p.o.) increases diuresis in beagle dogs.{52809} Furosemide (30 mg/kg) reduces ventricular collagen deposition and fibrosis in a rat model of dilated cardiomyopathy.{52810} It is also an inhibitor of carbonic anhydrase I (CAI), CAII, and CAIII (Kis = 0.052-0.065 µM) and organic ion transporter 1 (OAT1; Ki = 9.5 µM), as well as a GABAA receptor antagonist.{23242,29296,29298}
Brand:CaymanSKU:31789 - 1 mgAvailable on backorder
Fusapyrone is a broad-spectrum antifungal metabolite first isolated from Fusarium species. It has been investigated for use in the control of postharvest crop diseases such as inhibiting the growth of ochratoxin-producing strains of Aspergillus section Nigri in wine grapes.{32285}
Brand:CaymanSKU:20751 -Available on backorder
Fusapyrone is a broad-spectrum antifungal metabolite first isolated from Fusarium species. It has been investigated for use in the control of postharvest crop diseases such as inhibiting the growth of ochratoxin-producing strains of Aspergillus section Nigri in wine grapes.{32285}
Brand:CaymanSKU:20751 -Available on backorder
Fusarenon X is a type B trichothecene mycotoxin typically derived from Fusarium species. It is primarily found in contaminated cereals.{31924} Fusarenon X inhibits protein synthesis, which leads to disruption of DNA synthesis.{31924} As this occurs in actively proliferating cells, fusarenon X causes immunosuppression, intestinal malabsorption, developmental toxicity, and genotoxicity.{31924} Fusarenon X can be metabolized to fusarenon X-glucoside by infected plants.{29047}
Brand:CaymanSKU:11432 - 1 mgAvailable on backorder
Fusarenon X is a type B trichothecene mycotoxin typically derived from Fusarium species. It is primarily found in contaminated cereals.{31924} Fusarenon X inhibits protein synthesis, which leads to disruption of DNA synthesis.{31924} As this occurs in actively proliferating cells, fusarenon X causes immunosuppression, intestinal malabsorption, developmental toxicity, and genotoxicity.{31924} Fusarenon X can be metabolized to fusarenon X-glucoside by infected plants.{29047}
Brand:CaymanSKU:11432 - 100 µgAvailable on backorder
Fusarenon X is a type B trichothecene mycotoxin typically derived from Fusarium species. It is primarily found in contaminated cereals.{31924} Fusarenon X inhibits protein synthesis, which leads to disruption of DNA synthesis.{31924} As this occurs in actively proliferating cells, fusarenon X causes immunosuppression, intestinal malabsorption, developmental toxicity, and genotoxicity.{31924} Fusarenon X can be metabolized to fusarenon X-glucoside by infected plants.{29047}
Brand:CaymanSKU:11432 - 250 µgAvailable on backorder
Fusarenon X is a type B trichothecene mycotoxin typically derived from Fusarium species. It is primarily found in contaminated cereals.{31924} Fusarenon X inhibits protein synthesis, which leads to disruption of DNA synthesis.{31924} As this occurs in actively proliferating cells, fusarenon X causes immunosuppression, intestinal malabsorption, developmental toxicity, and genotoxicity.{31924} Fusarenon X can be metabolized to fusarenon X-glucoside by infected plants.{29047}
Brand:CaymanSKU:11432 - 500 µgAvailable on backorder
Fusaric acid is a picolinic acid derivative first isolated from fungi of the genus Fusarium.{29046} It is transformed to an N-methylamide derivative by many plant species infected by the mold.{29047} Both fusaric acid and fusaric acid methylamide are thought to contribute to the toxicoses developed from ingesting mold-infested feeds.{29047,29048} Fusaric acid can also synergize the toxicity of trichothecenes in certain assays.{29048}
Brand:CaymanSKU:-Available on backorder
Fusaric acid is a picolinic acid derivative first isolated from fungi of the genus Fusarium.{29046} It is transformed to an N-methylamide derivative by many plant species infected by the mold.{29047} Both fusaric acid and fusaric acid methylamide are thought to contribute to the toxicoses developed from ingesting mold-infested feeds.{29047,29048} Fusaric acid can also synergize the toxicity of trichothecenes in certain assays.{29048}
Brand:CaymanSKU:-Available on backorder
Fusaric acid is a picolinic acid derivative first isolated from fungi of the genus Fusarium.{29046} It is transformed to an N-methylamide derivative by many plant species infected by the mold.{29047} Both fusaric acid and fusaric acid methylamide are thought to contribute to the toxicoses developed from ingesting mold-infested feeds.{29047,29048} Fusaric acid can also synergize the toxicity of trichothecenes in certain assays.{29048}
Brand:CaymanSKU:-Available on backorder
Fusaric acid is a picolinic acid derivative first isolated from fungi of the genus Fusarium.{29046} It is transformed to an N-methylamide derivative by many plant species infected by the mold.{29047} Both fusaric acid and fusaric acid methylamide are thought to contribute to the toxicoses developed from ingesting mold-infested feeds.{29047,29048} Fusaric acid can also synergize the toxicity of trichothecenes in certain assays.{29048}
Brand:CaymanSKU:-Available on backorder
Fusarisetin A is a pentacyclic fungal metabolite first isolated from Fusarium species. At 3-30 µg/ml, it is reported to inhibit acinar morphogenesis, cell migration, and invasion in a 3D-matrigel assay system designed to study tumor cell motility.{32292}
Brand:CaymanSKU:20692 -Available on backorder
Fusarisetin A is a pentacyclic fungal metabolite first isolated from Fusarium species. At 3-30 µg/ml, it is reported to inhibit acinar morphogenesis, cell migration, and invasion in a 3D-matrigel assay system designed to study tumor cell motility.{32292}
Brand:CaymanSKU:20692 -Available on backorder
Fuscin is a quinonoid fungal metabolite originally isolated from O. fuscum that has diverse biological activities.{46199,46200,46201} It inhibits binding of the ADP/ATP translocase inhibitor atractyloside (Item No. 14804) to rat liver mitochondria in an ADP-dependent manner when used at a concentration of 50 μM in a radioligand binding assay.{46199} Fuscin (20 μM) reduces the glutathione content of rat liver mitochondria to 28% of controls and inhibits NADH oxidation in sonicated pigeon heart mitochondria preparations in a concentration-dependent manner.{46200} It competes with macrophage inflammatory protein 1α (MIP-1α) for binding to CCR5 chemokine receptors in vitro with an IC50 value of 21 μM.{46201}
Brand:CaymanSKU:27485 - 1 mgAvailable on backorder
Fuscin is a quinonoid fungal metabolite originally isolated from O. fuscum that has diverse biological activities.{46199,46200,46201} It inhibits binding of the ADP/ATP translocase inhibitor atractyloside (Item No. 14804) to rat liver mitochondria in an ADP-dependent manner when used at a concentration of 50 μM in a radioligand binding assay.{46199} Fuscin (20 μM) reduces the glutathione content of rat liver mitochondria to 28% of controls and inhibits NADH oxidation in sonicated pigeon heart mitochondria preparations in a concentration-dependent manner.{46200} It competes with macrophage inflammatory protein 1α (MIP-1α) for binding to CCR5 chemokine receptors in vitro with an IC50 value of 21 μM.{46201}
Brand:CaymanSKU:27485 - 10 mgAvailable on backorder
Fuscin is a quinonoid fungal metabolite originally isolated from O. fuscum that has diverse biological activities.{46199,46200,46201} It inhibits binding of the ADP/ATP translocase inhibitor atractyloside (Item No. 14804) to rat liver mitochondria in an ADP-dependent manner when used at a concentration of 50 μM in a radioligand binding assay.{46199} Fuscin (20 μM) reduces the glutathione content of rat liver mitochondria to 28% of controls and inhibits NADH oxidation in sonicated pigeon heart mitochondria preparations in a concentration-dependent manner.{46200} It competes with macrophage inflammatory protein 1α (MIP-1α) for binding to CCR5 chemokine receptors in vitro with an IC50 value of 21 μM.{46201}
Brand:CaymanSKU:27485 - 5 mgAvailable on backorder
Fusicoccin is a phytotoxin originally isolated from F. amygdali that induces death of tomato plants when used at concentrations ranging from 0.1 to 0.2 μg/ml.{43094} Topical administration of fusicoccin to tobacco (N. tabacum), sorghum (S. bicolor), cucumber (C. sativa), lucerne (M. sativa), and pokeweed (P. Americana) induces permanent opening of leaf stomata and wilting.{43095} Fusicoccin binds to the preformed complex between plasma membrane H+-ATPase and a 14-3-3 protein in plants to stabilize and activate the enzyme leading to dysregulated solute transport and control of transmembrane electric potential.{43096} It also stabilizes eukaryotic 14-3-3 protein interactions with binding partners containing a C-terminal 14-3-3 recognition motif, also known as a mode 3 motif, such as ERα, GPIbα, TASK3, CTFR, and p53 in vitro.{43097} Fusicoccin stimulates cortical neurite outgrowth in a 14-3-3 protein-dependent manner (EC50 = 29 μM).{43098} In vivo, topical administration of fusicoccin to the injury site reduces collapse and retraction of severed axons in a mouse model of spinal cord injury.
Brand:CaymanSKU:25020 - 1 mgAvailable on backorder
Fusidic acid is a fusidane antibiotic originally isolated from F. coccineum.{54000} It is active against the Gram-positive bacteria S. aureus, S. pyogenes, C. diphtheriae, B. subtilis, and C. tetani (MIC50s = 0.01-20 µg/ml) but not the Gram-negative bacteria E. coli, S. typhimurium, and P. vulgaris or the fungi C. albicans and A. fumigatus (MIC50s = >100 µg/ml for all).{54001} Fusidic acid inhibits ribosomal recycling and protein translocation, processes mediated by elongation factor G (EF-G), in isolated E. coli ribosomes (IC50s = ~0.1 and ~200 µM, respectively).{54002} Topical administration of fusidic acid (2%) reduces the number of skin colony forming units (CFUs) and levels of TNF-α and IL-6 in a mouse model of methicillin-resistant S. aureus (MRSA) skin wound infection.{54003}
Brand:CaymanSKU:- Fusidic acid is a fusidane antibiotic originally isolated from F. coccineum.{54000} It is active against the Gram-positive bacteria S. aureus, S. pyogenes, C. diphtheriae, B. subtilis, and C. tetani (MIC50s = 0.01-20 µg/ml) but not the Gram-negative bacteria E. coli, S. typhimurium, and P. vulgaris or the fungi C. albicans and A. fumigatus (MIC50s = >100 µg/ml for all).{54001} Fusidic acid inhibits ribosomal recycling and protein translocation, processes mediated by elongation factor G (EF-G), in isolated E. coli ribosomes (IC50s = ~0.1 and ~200 µM, respectively).{54002} Topical administration of fusidic acid (2%) reduces the number of skin colony forming units (CFUs) and levels of TNF-α and IL-6 in a mouse model of methicillin-resistant S. aureus (MRSA) skin wound infection.{54003}
Brand:CaymanSKU:- Fusidic acid is a fusidane antibiotic originally isolated from F. coccineum.{54000} It is active against the Gram-positive bacteria S. aureus, S. pyogenes, C. diphtheriae, B. subtilis, and C. tetani (MIC50s = 0.01-20 µg/ml) but not the Gram-negative bacteria E. coli, S. typhimurium, and P. vulgaris or the fungi C. albicans and A. fumigatus (MIC50s = >100 µg/ml for all).{54001} Fusidic acid inhibits ribosomal recycling and protein translocation, processes mediated by elongation factor G (EF-G), in isolated E. coli ribosomes (IC50s = ~0.1 and ~200 µM, respectively).{54002} Topical administration of fusidic acid (2%) reduces the number of skin colony forming units (CFUs) and levels of TNF-α and IL-6 in a mouse model of methicillin-resistant S. aureus (MRSA) skin wound infection.{54003}
Brand:CaymanSKU:- Fusidic acid is a fusidane antibiotic originally isolated from F. coccineum.{54000} It is active against the Gram-positive bacteria S. aureus, S. pyogenes, C. diphtheriae, B. subtilis, and C. tetani (MIC50s = 0.01-20 µg/ml) but not the Gram-negative bacteria E. coli, S. typhimurium, and P. vulgaris or the fungi C. albicans and A. fumigatus (MIC50s = >100 µg/ml for all).{54001} Fusidic acid inhibits ribosomal recycling and protein translocation, processes mediated by elongation factor G (EF-G), in isolated E. coli ribosomes (IC50s = ~0.1 and ~200 µM, respectively).{54002} Topical administration of fusidic acid (2%) reduces the number of skin colony forming units (CFUs) and levels of TNF-α and IL-6 in a mouse model of methicillin-resistant S. aureus (MRSA) skin wound infection.{54003}
Brand:CaymanSKU:-
Fuziline is a diterpene alkaloid that has been found in A. lateralis and has cardioprotective activity.{54422} It reduces sodium pentobarbital-induced cell death in primary neonatal rat cardiomyocytes when used at concentrations ranging from 0.1 to 10 µM. Fuziline (0.5 µM) reduces the production of reactive oxygen species (ROS) and apoptosis induced by isoproterenol (Item No. 15592) in H9c2 rat cardiomyocytes.{54421} In vivo, fuziline (3 and 10 mg/kg) reduces isoproterenol-induced myocardial necrosis and fibrosis in rats.
Brand:CaymanSKU:30889 - 1 mgAvailable on backorder
Fuziline is a diterpene alkaloid that has been found in A. lateralis and has cardioprotective activity.{54422} It reduces sodium pentobarbital-induced cell death in primary neonatal rat cardiomyocytes when used at concentrations ranging from 0.1 to 10 µM. Fuziline (0.5 µM) reduces the production of reactive oxygen species (ROS) and apoptosis induced by isoproterenol (Item No. 15592) in H9c2 rat cardiomyocytes.{54421} In vivo, fuziline (3 and 10 mg/kg) reduces isoproterenol-induced myocardial necrosis and fibrosis in rats.
Brand:CaymanSKU:30889 - 10 mgAvailable on backorder
Fuziline is a diterpene alkaloid that has been found in A. lateralis and has cardioprotective activity.{54422} It reduces sodium pentobarbital-induced cell death in primary neonatal rat cardiomyocytes when used at concentrations ranging from 0.1 to 10 µM. Fuziline (0.5 µM) reduces the production of reactive oxygen species (ROS) and apoptosis induced by isoproterenol (Item No. 15592) in H9c2 rat cardiomyocytes.{54421} In vivo, fuziline (3 and 10 mg/kg) reduces isoproterenol-induced myocardial necrosis and fibrosis in rats.
Brand:CaymanSKU:30889 - 25 mgAvailable on backorder
Fuziline is a diterpene alkaloid that has been found in A. lateralis and has cardioprotective activity.{54422} It reduces sodium pentobarbital-induced cell death in primary neonatal rat cardiomyocytes when used at concentrations ranging from 0.1 to 10 µM. Fuziline (0.5 µM) reduces the production of reactive oxygen species (ROS) and apoptosis induced by isoproterenol (Item No. 15592) in H9c2 rat cardiomyocytes.{54421} In vivo, fuziline (3 and 10 mg/kg) reduces isoproterenol-induced myocardial necrosis and fibrosis in rats.
Brand:CaymanSKU:30889 - 5 mgAvailable on backorder
FX1 is an inhibitor of the transcription factor B cell lymphoma 6 (BCL6; IC50 = ~35 μM).{43297} It is selective for BCL6 over a panel of 50 kinases at a concentration of 10 μM. FX1 (50 μM) reduces recruitment of the BCL6 corepressor proteins SMRT and BCOR to the BCL6 target loci CDKN1A, CD69, and CXCR4 in a ChIP assay. It represses growth of Farage, SUDLH-6, DOHH-2, OCI-Ly7, RCK8, SUDHL-4, OCI-Ly1, and SC-1 BCL6-dependent cell lines (GI50s = 16-54 μM) but not OCI-LY1-B50, Karpas 433, OCI-Ly19, or Toledo BCL6-independent cell lines (GI50s = >125 μM). In vivo, FX1 (50 mg/kg) reduces tumor volume in an HBL-1 large B cell lymphoma mouse xenograft model.
Brand:CaymanSKU:23908 - 1 mgAvailable on backorder
FX1 is an inhibitor of the transcription factor B cell lymphoma 6 (BCL6; IC50 = ~35 μM).{43297} It is selective for BCL6 over a panel of 50 kinases at a concentration of 10 μM. FX1 (50 μM) reduces recruitment of the BCL6 corepressor proteins SMRT and BCOR to the BCL6 target loci CDKN1A, CD69, and CXCR4 in a ChIP assay. It represses growth of Farage, SUDLH-6, DOHH-2, OCI-Ly7, RCK8, SUDHL-4, OCI-Ly1, and SC-1 BCL6-dependent cell lines (GI50s = 16-54 μM) but not OCI-LY1-B50, Karpas 433, OCI-Ly19, or Toledo BCL6-independent cell lines (GI50s = >125 μM). In vivo, FX1 (50 mg/kg) reduces tumor volume in an HBL-1 large B cell lymphoma mouse xenograft model.
Brand:CaymanSKU:23908 - 10 mgAvailable on backorder
FX1 is an inhibitor of the transcription factor B cell lymphoma 6 (BCL6; IC50 = ~35 μM).{43297} It is selective for BCL6 over a panel of 50 kinases at a concentration of 10 μM. FX1 (50 μM) reduces recruitment of the BCL6 corepressor proteins SMRT and BCOR to the BCL6 target loci CDKN1A, CD69, and CXCR4 in a ChIP assay. It represses growth of Farage, SUDLH-6, DOHH-2, OCI-Ly7, RCK8, SUDHL-4, OCI-Ly1, and SC-1 BCL6-dependent cell lines (GI50s = 16-54 μM) but not OCI-LY1-B50, Karpas 433, OCI-Ly19, or Toledo BCL6-independent cell lines (GI50s = >125 μM). In vivo, FX1 (50 mg/kg) reduces tumor volume in an HBL-1 large B cell lymphoma mouse xenograft model.
Brand:CaymanSKU:23908 - 25 mgAvailable on backorder
FX1 is an inhibitor of the transcription factor B cell lymphoma 6 (BCL6; IC50 = ~35 μM).{43297} It is selective for BCL6 over a panel of 50 kinases at a concentration of 10 μM. FX1 (50 μM) reduces recruitment of the BCL6 corepressor proteins SMRT and BCOR to the BCL6 target loci CDKN1A, CD69, and CXCR4 in a ChIP assay. It represses growth of Farage, SUDLH-6, DOHH-2, OCI-Ly7, RCK8, SUDHL-4, OCI-Ly1, and SC-1 BCL6-dependent cell lines (GI50s = 16-54 μM) but not OCI-LY1-B50, Karpas 433, OCI-Ly19, or Toledo BCL6-independent cell lines (GI50s = >125 μM). In vivo, FX1 (50 mg/kg) reduces tumor volume in an HBL-1 large B cell lymphoma mouse xenograft model.
Brand:CaymanSKU:23908 - 5 mgAvailable on backorder
Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.{17947,14336,13185} Wnt proteins initiate cell signaling by binding Frizzled (Fz) receptors, a family of G protein-coupled receptors. FzM1 is an allosteric ligand of Fz4.{30790} At 10 µM, it inhibits nuclear translocation of β-catenin in U87MG glioma cells treated with lithium chloride, a GSK3 inhibitor that enhances the Wnt canonical signaling pathway.{30790} FzM1 impairs the ability of U87MG cells to form neurospheres in culture and stimulates the differentiation of Caco-2 epithelial colorectal adenocarcinoma cells.{30790}
Brand:CaymanSKU:-Available on backorder
Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.{17947,14336,13185} Wnt proteins initiate cell signaling by binding Frizzled (Fz) receptors, a family of G protein-coupled receptors. FzM1 is an allosteric ligand of Fz4.{30790} At 10 µM, it inhibits nuclear translocation of β-catenin in U87MG glioma cells treated with lithium chloride, a GSK3 inhibitor that enhances the Wnt canonical signaling pathway.{30790} FzM1 impairs the ability of U87MG cells to form neurospheres in culture and stimulates the differentiation of Caco-2 epithelial colorectal adenocarcinoma cells.{30790}
Brand:CaymanSKU:-Available on backorder
Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.{17947,14336,13185} Wnt proteins initiate cell signaling by binding Frizzled (Fz) receptors, a family of G protein-coupled receptors. FzM1 is an allosteric ligand of Fz4.{30790} At 10 µM, it inhibits nuclear translocation of β-catenin in U87MG glioma cells treated with lithium chloride, a GSK3 inhibitor that enhances the Wnt canonical signaling pathway.{30790} FzM1 impairs the ability of U87MG cells to form neurospheres in culture and stimulates the differentiation of Caco-2 epithelial colorectal adenocarcinoma cells.{30790}
Brand:CaymanSKU:-Available on backorder